Results 11 to 20 of about 407,386 (306)

Epitope mapping of ORF3a Protein SARS-CoV-2 in Indonesia through computational study

Journal of Tropical Life Science, 2022
In Indonesia, the vaccine for SARS-CoV-2 is still being developed. ORF3a protein of SARS-CoV-2 could be a potential peptide to be used in the vaccine, therapeutic antibodies, and diagnostic kit development. We used the computational approach in designing
Hartiyowidi Yuliawuri, Jeanne Elvia Christian   +1 more
doaj   +1 more source

A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV

Science, 2020
Targeting the SARS-CoV-2 spike The surface of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is decorated with trimeric spikes that bind to host cell receptors.
M. Yuan, N. Wu, Xueyong Zhu, C. D. Lee, R. T. So, Huibin Lv, C. K. Mok, I. Wilson   +7 more
semanticscholar   +1 more source

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

Science, 2020
Profiling coronaviruses Among the coronaviruses that infect humans, four cause mild common colds, whereas three others, including the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), result in severe infections.
Ellen Shrock, Ellen Shrock, Eric Fujimura, Eric Fujimura, T. Kula, T. Kula, R. Timms, R. Timms, I-Hsiu Lee, Yumei Leng, Yumei Leng, M. Robinson, Brandon M. Sie, Brandon M. Sie, Mamie Z. Li, Mamie Z. Li, Yuezhou Chen, J. Logue, Adam Zuiani, Denise J. McCulloch, Felipe J. N. Lelis, Stephanie N. Henson, Daniel R. Monaco, M. Travers, S. Habibi, W. Clarke, P. Caturegli, Oliver Laeyendecker, Oliver Laeyendecker, A. Piechocka-Trocha, Jonathan Z. Li, A. Khatri, H. Chu, A. Villani, Kyle R. Kays, M. Goldberg, N. Hacohen, M. Filbin, Xu G. Yu, B. D. Walker, B. D. Walker, D. Wesemann, H. Larman, J. Lederer, Stephen J. Elledge, Stephen J. Elledge   +45 more
semanticscholar   +1 more source

Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting

Cell Reports Medicine, 2021
Summary CD8+ T cell recognition of peptide epitopes plays a central role in immune responses against pathogens and tumors. However, the rules that govern which peptides are truly recognized by existing T cell receptors (TCRs) remain poorly understood ...
J. Schmidt, Angela R. Smith, Morgane Magnin, Julien Racle, J. Devlin, S. Bobisse, J. Cesbron, Victor Bonnet, Santiago J. Carmona, Florian Huber, G. Ciriello, D. Speiser, M. Bassani-Sternberg, G. Coukos, B. Baker, A. Harari, D. Gfeller   +16 more
semanticscholar   +1 more source

Epitope Tagging [PDF]

BioTechniques, 2008
Epitope tagging is widely used in the characterization of newly discovered proteins. This review presents an overview of how the technique evolved and how it is being used today, with a focus on its use in the study of protein-protein interactions. In addition, the evolution of the technique for proteomic analyses is described.
openaire   +3 more sources

The Immune Epitope Database (IEDB): 2018 update

Nucleic Acids Res., 2018
The Immune Epitope Database (IEDB, iedb.org) captures experimental data confined in figures, text and tables of the scientific literature, making it freely available and easily searchable to the public. The scope of the IEDB extends across immune epitope
R. Vita, Swapnil Mahajan, James A. Overton, Sandeep Kumar Dhanda, Sheridan Martini, Jason R. Cantrell, D. Wheeler, A. Sette, Bjoern Peters   +8 more
semanticscholar   +1 more source

A candidate multi-epitope vaccine against SARS-CoV-2

Scientific Reports, 2020
In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively.
Tamalika Kar, Utkarsh Narsaria, Srijita Basak, Debashrito Deb, F. Castiglione, D. Mueller, A. Srivastava   +6 more
semanticscholar   +1 more source

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Nature, 2021
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection1.
Jenna J. Guthmiller, Julianna Han, Henry A. Utset, Lei Li, L. Lan, Carole Henry, Christopher T. Stamper, Meagan McMahon, George O’Dell, M. Fernández-Quintero, Alec W. Freyn, F. Amanat, O. Stovicek, Lauren E. Gentles, Sara T. Richey, A. T. de la Peña, Victoria C. Rosado, H. Dugan, Nai-Ying Zheng, Micah E. Tepora, Dalia J. Bitar, Siriruk Changrob, Shirin Strohmeier, Min Huang, A. García‐Sastre, K. Liedl, J. Bloom, R. Nachbagauer, P. Palese, F. Krammer, Lynda Coughlan, A. Ward, P. Wilson   +32 more
semanticscholar   +1 more source

Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors

mAbs, 2020
Ebola virus (EBOV) can cause severe hemorrhagic fever in humans, and no approved treatment is currently available. Although several antibodies have achieved good protection in animal models, the potential emerging isolates of ebolavirus and the unknown ...
Pengfei Fan, Xiangyang Chi, Guodong Liu, Guanying Zhang, Zhengshan Chen, Yujiao Liu, Ting Fang, Jianmin Li, Logan Banadyga, Shihua He, Changming Yu, Xiangguo Qiu, Wei Chen   +12 more
doaj   +1 more source

Development of epitope‐based peptide vaccine against novel coronavirus 2019 (SARS‐COV‐2): Immunoinformatics approach

Journal of Medical Virology, 2020
Recently, a novel coronavirus (SARS‐COV‐2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS‐CoV and MERS‐CoV. The situation is getting worse and worse, therefore, there is an urgent need for
M. Bhattacharya, Ashish Ranjan Sharma, Prasanta Patra, Pratik Ghosh, Garima Sharma, Bidhan Chandra Patra, Sang-Soo Lee, C. Chakraborty   +7 more
semanticscholar   +1 more source