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Predefined spacers between epitopes on a recombinant epitope-peptide impacted epitope-specific antibody response

Immunology Letters, 2005
We have developed a widely applicable method to construct epitope-peptide gene for epitope-vaccine strategy recently. In this study, we wanted to know whether the predefined spacers between epitopes on a recombinant epitope-peptide impacted the production of epitope-specific antibodies.
Zuqiang, Liu   +2 more
openaire   +2 more sources

Immunoglobulin Epitopes in Primates

Vox Sanguinis, 1979
Abstract. Non‐human primate sera were investigated for the presence of various human immunoglobulin epitopes including allotypes of ϰ‐, γ1‐, γ2‐, γ3‐ and α2‐chains, isotypes of ϰ‐, γ1‐, γ2‐, γ3‐, γ4‐, α1‐, α2‐ and μ‐chains and iso‐allotypes. The non‐human primate sera comprised representatives of several species of apes, Old World monkeys, New World ...
E, van Loghem, G, de Lange
openaire   +2 more sources

Distinct epitopes on amiloride

American Journal of Physiology-Cell Physiology, 1989
Most Na(+)-selective transport proteins are inhibited by the drug amiloride. Studies using amiloride analogues suggest that specific regions of amiloride might participate in binding to receptors on these transport proteins. To determine whether certain domains of this drug are recognized as distinct epitopes, amiloride was coupled to albumin through ...
T R, Kleyman   +4 more
openaire   +2 more sources

Food Allergen Epitope Mapping.

Journal of Agricultural and Food Chemistry, 2018
With the increased global awareness and rise in food allergies, a multifold interest in food allergens is evident. The presence of undeclared food allergens results in expensive food recalls and increased risks of anaphylaxis for the sensitive ...
Changqi Liu, S. Sathe
semanticscholar   +1 more source

Epitopes on Rh Proteins

Vox Sanguinis, 2000
Analyses of the reactions of monoclonal anti‐D with Rh D variant red cells have shown that there are at least 24 different epitopes of the Rh D antigen. Similar studies Of Rh E variant red cells with monoclonal anti‐E indicate that there are at least 4 epitopes of the Rh E antigen.
M L, Scott   +4 more
openaire   +2 more sources

Epitope Peptides and Immunotherapy

Current Protein & Peptide Science, 2007
Allergic diseases affect atopic individuals, who synthesize specific Immunoglobulins E (IgE) to environmental allergens, usually proteins or glycoproteins. These allergens include grass and tree pollens, indoor allergens such as house dust mites and animal dander, and various foods.
openaire   +2 more sources

Prediction of Antibody Epitopes

2015
Antibodies recognize their cognate antigens in a precise and effective way. In order to do so, they target regions of the antigenic molecules that have specific features such as large exposed areas, presence of charged or polar atoms, specific secondary structure elements, and lack of similarity to self-proteins.
Morten, Nielsen, Paolo, Marcatili
openaire   +2 more sources

Epitope Data Bank

1996
The fine specificity of monoclonal antibodies is the indispensable information for the elucidation of the protein-ligand interaction. The data on the epitope of antigens have been desperately required in immunology, pharmacology and molecular biology because the epitope is specifically recognized by antibodies.
Lunjiang Ling   +3 more
openaire   +1 more source

Allergen structures and epitopes

Allergy, 2011
To cite this article: Meno KH. Allergen structures and epitopes. Allergy 2011; 66 (Suppl. 95): 19–21.AbstractHuman type 1 hypersensitivity diseases such as allergic rhinoconjunctivitis are characterized by allergen‐specific IgE antibodies produced in allergic individuals after allergen exposure.
openaire   +2 more sources

An Introduction to Epitope Mapping

2018
Antibodies are protein molecules used routinely for therapeutic, diagnostic, and research purposes due to their exquisite ability to selectively recognize and bind a given antigen. The particular area of the antigen recognized by the antibody is called the epitope, and for proteinaceous antigens the epitope can be of complex nature.
Johan, Nilvebrant, Johan, Rockberg
openaire   +2 more sources

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