Results 91 to 100 of about 1,474,718 (406)
Intact Transition Epitope Mapping – Targeted High-Energy Rupture of Extracted Epitopes (ITEM-THREE)*
Molecular & Cellular Proteomics, 2019 ITEM-THREE enables rapid epitope mapping. Sample consumption is minimized and in-solution handling reduced to mixing of antibody and antigen peptide solutions.
Bright D. Danquah +7 more
semanticscholar +1 more source
Virology Journal, 2023 Background Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease caused by the Dabie bandavirus, [or SFTS virus (SFTSV)] that has become increasingly widespread since it was first reported in 2009.
Kyungha Lee +4 more
doaj +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Fundamentals and Methods for T- and B-Cell Epitope Prediction
Journal of Immunology Research, 2017 Adaptive immunity is mediated by T- and B-cells, which are immune cells capable of developing pathogen-specific memory that confers immunological protection.
Jose L. Sanchez-Trincado +2 more
doaj +1 more source
Recent advances and challenges in antigen engineering & vaccine development [PDF]
, 2014 textVaccines play a vital role in public health by preventing infectious disease across the globe. Vaccine formulations represent a weakened form of a microbe or toxin that is injected into the human body to elicit an immune response, generating ...
Kornahrens, William Joseph
core
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Virology Journal, 2019 Porcine parvovirus (PPV) is a DNA virus that causes reproductive failure in gilts and sows, resulting in embryonic and fetal losses worldwide. Epitope mapping of PPV is important for developing new vaccines. In this study, we used spot synthesis analysis
Ancelmo Rabelo de Souza +6 more
doaj +1 more source
Characterization of antibodies directed against the Ankrd2 human muscle protein [PDF]
Archives of Biological Sciences, 2009 In order to study the function of the Ankrd2 protein, for which commercial antibodies are not available, we report the production and analysis of polyclonal antibodies to full-length Ankrd2 and its C-terminal and N-terminal regions, as well as a ...
Kojić Snežana +2 more
doaj +1 more source
Mapping of conformational autoantibody epitopes in ZNT8 [PDF]
Diabetes/Metabolism Research and Reviews, 2011 AbstractBackgroundIdentification of the major humoral epitopes in zinc transporter 8 (ZnT8) will expand the range of biomarkers for human type 1 diabetes and may provide clues to the mechanisms governing disease progression. Our initial studies suggested that most ZnT8‐reactive sera recognize conformational epitopes in the final 100aa region of the ...
Lisa M. Frisch +3 more
openaire +3 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source