Results 111 to 120 of about 1,474,718 (406)
A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies [PDF]
, 2010 A promising direction in drug development is to exploit the ability of natural killer cells to kill antibody-labeled target cells. Monoclonal antibodies and drugs designed to elicit this effect typically bind cell-surface epitopes that are overexpressed on target cells but also present on other cells.
arxiv +1 more source
Dual-topology insertion of a dual-topology membrane protein. [PDF]
, 2015 Some membrane transporters are dual-topology dimers in which the subunits have inverted transmembrane topology. How a cell manages to generate equal populations of two opposite topologies from the same polypeptide chain remains unclear.
Bowie, James U +2 more
core
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
Viruses, 2019 Human norovirus (HuNoV) is the leading cause of acute nonbacterial gastroenteritis. Vaccine design has been confounded by the antigenic diversity of these viruses and a limited understanding of protective immunity. We reviewed 77 articles published since
Jessica M. van Loben Sels, K. Green
semanticscholar +1 more source
Rational engineering of a human anti-dengue antibody through experimentally validated computational docking. [PDF]
PLoS ONE, 2013 Antibodies play an increasing pivotal role in both basic research and the biopharmaceutical sector, therefore technology for characterizing and improving their properties through rational engineering is desirable.
Luca Simonelli +7 more
doaj +1 more source
Predicting Fixation Tendencies of the H3N2 Influenza Virus by Free Energy Calculation [PDF]
J. Chem. Theory Comput. 7 (2011) 1259-1272, 2012 Influenza virus evolves to escape from immune system antibodies that bind to it. We used free energy calculations with Einstein crystals as reference states to calculate the difference of antibody binding free energy ($\Delta\Delta G$) induced by amino acid substitution at each position in epitope B of the H3N2 influenza hemagglutinin, the key target ...
arxiv
Autoantibody recognition mechanisms of MUC1 [PDF]
, 2016 The most cost-effective blood-based, noninvasive molecular cancer biomarkers are based on p53 epitopes and MUC1 tandem repeats. Here we use dimensionally compressed bioinformatic fractal scaling analysis to compare the two distinct and comparable probes, which examine different sections of the autoantibody population, achieving combined sensitivities ...
arxiv +1 more source
A nonstructural polypeptide encoded by immediate-early transcription unit 1 of murine cytomegalovirus is recognized by cytolytic T lymphocytes [PDF]
, 1987 We have constructed target cells by cotransfection of the MHC gene Ld and fragments of murine cytomegalovirus (MCMV) DNA coding for nonstructural immediate-early (IE) proteins.
Keil, Günther M. +4 more
core +2 more sources
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
Сибирский онкологический журнал, 2016 This article presents identification and mapping of an epitope in the protein ErbB-2 which binds to the monoclonal antibody 4B8 intended for use in immunochemistry to estimate the level of ErbB-2 production.
M. B. Borgoyakova, A. A. Ilichev
doaj