Results 131 to 140 of about 1,474,718 (406)

Interactions of Poly(amidoamine) Dendrimers with Human Serum Albumin: Binding Constants and Mechanisms [PDF]

, 2011
The interactions of nanomaterials with plasma proteins have a significant impact on their in vivo transport and fate in biological fluids. This article discusses the binding of human serum albumin (HSA) to poly(amidoamine) [PAMAM] dendrimers.
Diallo, Mamadou S., Giri, Jyotsnendu, Goddard, William A., III, Kumar, Rajeev, Liu, Yi, Simpson, André J., Woods, Gwen C.   +6 more
core   +1 more source

T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects [PDF]

, 2009
Lipid transfer proteins (LTPs), particularly peach Pru p 3, are the most relevant plant food allergens in the South of Europe, and, therefore, their allergic properties have been extensively studied.
Abbas, Araceli Diaz-Perales, Belen Garcia-Carrasco, Bohle, Bohle, Burks, Cuesta-Herranz, Cuesta-Herranz, Diaz-Perales, Diaz-Perales, Ebner, Esther Compés, Fernandez-Rivas, Gabriel Salcedo, Garcia-Casado, Glaspole, Haselden, Jahn-Schmid, Javier Cuesta-Herranz, Kanny, Laurer, Leticia Tordesillas, Lombardero, Luis F. Pacios, Miguel Gonzalez-Muñoz, Pacios, Pasquato, Rosa Sanchez-Monge, Salcedo, Sanchez-Monge, Schade, Smith, Tanabe, Thomas, Turcanu, van Ree, Wagner, Woodfolk, Zeiler, Zuidmeer   +39 more
core   +2 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Can alternative epitope mapping approaches increase the impact of B‐cell epitopes in food allergy diagnostics?

Clinical and Experimental Allergy, 2018
In vitro allergy diagnostics are currently based on the detection of specific IgE binding on intact allergens or a mixture thereof. This approach has drawbacks as it may yield false‐negative and/or false‐positive results.
Anna M. Ehlers, M. Blankestijn, A. Knulst, Marco Klinge, H. Otten   +4 more
semanticscholar   +1 more source

Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional Activity

Biomolecules, 2020
The pathogenicity of many bacteria, including Streptococcus pneumoniae, depends on pore-forming toxins (PFTs) that cause host cell lysis by forming large pores in cholesterol-containing cell membranes.
Indre Kucinskaite-Kodze, Martynas Simanavicius, Justas Dapkunas, Milda Pleckaityte, Aurelija Zvirbliene   +4 more
doaj   +1 more source

A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles [PDF]

, 2016
Survivin, the smallest member of the inhibitor of apoptosis protein family, plays a central role during mitosis and exerts a cytoprotective function. Survivin is highly expressed in most cancer types and contributes to multiple facets of carcinogenesis ...
Beghein, Els, De Ganck, Ariane, Gettemans, Jan, Van Audenhove, Isabel, Verhelle, Adriaan, Zwaenepoel, Olivier   +5 more
core   +2 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Identification and epitope mapping of anti-p72 single-chain antibody against African swine fever virus based on phage display antibody library

Journal of Integrative Agriculture, 2023
African swine fever virus (ASFV) is a lethal pathogen that causes severe threats to the global swine industry and it has already had catastrophic socio-economic effects. To date, no licensed prophylactic vaccine exists. Limited knowledge exists about the
Jin-xing SONG, Meng-xiang WANG, Yi-xuan ZHANG, Bo WAN, Yong-kun DU, Guo-qing ZHUANG, Zi-bin LI, Song-lin QIAO, Rui GENG, Ya-nan WU, Gai-ping ZHANG   +10 more
doaj  

Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus [PDF]

, 1987
The murine immediate-early (IE) protein pp89 is a nonstructural virus- encoded phosphoprotein residing in the nucleus of infected cells, where it acts as transcriptional activator.
Bertholet, Christine, Jonjic, Stipan, Koszinowski, Ulrich H., Volkmer, Hansjürgen, Wittek, Riccardo   +4 more
core   +4 more sources

Epitope Mapping of Human Alpha-Fetoprotein

Tumor Biology, 1998
Thirty monoclonal antibodies (MoAbs) to human alpha-fetoprotein (AFP) were compared with one another by two methods: Immunoaffinity electrochromatography or additive ELISA. The first method permitted to analyse the epitopes of native AFP in solution [Abelev et al., Immunol Lett 1994;40:133-138] while the other approach also detects the epitopes of ...
E.F. Yakimenko, A.I. Goussev, A.K. Yazova, E.R. Karamova, J. Hilgers, G.I. Abelev   +5 more
openaire   +3 more sources