Results 151 to 160 of about 48,857 (310)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The mass spectrometric intact transition epitope mapping method supports protein engineering of foldon trimer variants. [PDF]

Sci Rep
Koy C, Zimmer T, Opuni KFM, Geyer A, Glocker MO.   +4 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

B-cell epitope mapping of Orthoflavivirus zikaense in mother-newborn immune interaction reveals postnatal immune signatures. [PDF]

Sci Rep
Soares AP, Chávez-Olórtegui C, de Lima Neto DF, Dos Passos Cunha M, Grillo TC, da Silva MF, Silva ACB, Bertozzi APAP, Bonafé CFS, Passos SD, de Andrade Zanotto PM.   +10 more
europepmc   +1 more source

Cross-neutralization between three mumps viruses & mapping of haemagglutinin-neuraminidase (HN) epitopes

, 2016
SunilR Vaidya, GarimaM Dvivedi, SantoshkumarM Jadhav   +2 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Epitope Mapping of <i>Senecavirus A</i> 3A Protein Using Monoclonal Antibodies. [PDF]

Transbound Emerg Dis
Meng L, Tian XX, Xiang XY, Qi XY, Zhou HR, Xiao PY, An TQ, Meng FD, Wang HW.   +8 more
europepmc   +1 more source

Hydrogen-Deuterium Exchange Epitope Mapping of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase. [PDF]

Anal Chem, 2023
O'Leary TR, Balasubramaniam D, Hughes K, Foster D, Boyles J, Coleman K, Griffin PR.   +6 more
europepmc   +1 more source

Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus hemagglutinin protein

, 2017
Ruisong Yu, Rui Zhu, Weixiang Gao, Ming Zhang, Shijuan Dong, Bingqing Chen, Yu Li, Chunfang Xie, Fengying Jiang, Zhen Li   +9 more
openalex   +2 more sources

Immunological Characterization of α Antigen of Mycobacterium kansasii: B‐Cell Epitope Mapping [PDF]

, 1998
Mariko Naito, Ohara, Sohkichi Matsumoto, Yamada   +3 more
openalex   +1 more source