Results 161 to 170 of about 1,474,718 (406)

Small nuclear RNA-associated proteins are immunologically related as revealed by mapping of autoimmune reactive B-cell epitopes. [PDF]

, 1989
W J Habets, Peter Sillekens, M H Hoet, George McAllister, M R Lerner, Walther J. van Venrooij   +5 more
openalex   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

A study on B-cell epitope prediction based on QSVM and VQC [PDF]

arXiv
This study investigates quantum computing's role in B-cell epitope prediction using Quantum Support Vector Machine (QSVM) and Variational Quantum Classifier (VQC). It highlights the potential of quantum machine learning in bioinformatics, addressing computational efficiency limitations of traditional methods as data complexity grows.
arxiv  

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]

, 2019
BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G, Antonyan, Tatevik, Blurton-Jones, Mathew, Chailyan, Gor, Coburn, Morgan A, Cribbs, David H, Danhash, Emma, Davtyan, Hayk, Ghochikyan, Anahit, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Petrovsky, Nikolai, Petrushina, Irina, Svystun, Olga, Zagorski, Karen   +14 more
core  

Epitope profiling via mixture modeling of ranked data

, 2014
We propose the use of probability models for ranked data as a useful alternative to a quantitative data analysis to investigate the outcome of bioassay experiments, when the preliminary choice of an appropriate normalization method for the raw numerical ...
Benter, Busse, Caron, Critchlow, Critchlow, Croon, Croon, Dempster, Diaconis, Fligner, Fligner, Fraley, Gabrielli, Gormley, Gormley, Gormley, Gormley, Guiver, Hunter, Hunter, Lange, Lee, Luce, Marden, McLachlan, McLachlan, McNicholas, Murphy, Plackett, Schwarz, Vaida   +30 more
core   +1 more source

Epitope mapping of the von Willebrand factor subunit distinguishes fragments present in normal and type IIA von Willebrand disease from those generated by plasmin. [PDF]

, 1987
Scott D. Berkowitz, J Dent, James R. Roberts, Yoshihiro Fujimura, EF Plow, Koiti Titani, Zaverio M. Ruggeri, T S Zimmerman   +7 more
openalex   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics.

Analytical Chemistry, 2017
Higher-order structure (HOS) is a crucial determinant for the biological functions and quality attributes of protein therapeutics. Mass spectrometry (MS)-based protein footprinting approaches play an important role in elucidating the relationship between
K. Li, Guodong Chen, Jingjie Mo, Richard Y.-C. Huang, Ekaterina G. Deyanova, B. Beno, Steven R. O’Neil, A. Tymiak, M. Gross   +8 more
semanticscholar   +1 more source

Mapping the antigenic epitope for a monoclonal antibody against lysozyme. [PDF]

, 1982
Sandra J. Smith‐Gill, Allan C. Wilson, M Potter, E M Prager, Richard J. Feldmann, C R Mainhart   +5 more
openalex   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source