Results 171 to 180 of about 100,019 (301)

Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. [PDF]

, 1990
Ylva Magnusson, Stéfano Marullo, S. Høyer, Finn Waagstein, Birger Andersson, Anders Vahlne, J G Guillet, A. Donny Strosberg, Åke Hjalmarson, Johan Hoebeke   +9 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Epitope mapping strategies for immunogenicity mitigation in streptokinase therapeutics: an in-silico study. [PDF]

Sci Rep
Hajizade MS, Rahbar MR, Kabiri M, Hajimonfarednejad M, Raee MJ.   +4 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

B-cell epitope mapping of VP5 protein of bluetongue virus serotype 1 using monoclonal antibodies. [PDF]

Virus Res
Meng F, Liu X, Song Y, Hu X, Tian Z, Guan G, Tang L, Yin H, Du J.   +8 more
europepmc   +1 more source

Epitope mapping of the non-structural protein 2 (NSP2) of rotavirus

Chieh Ren Quek
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

SARS-CoV-2 epitope mapping on microarrays highlights strong immune-response to N protein region [PDF]

, 2020
Angelo Musicò, Roberto Frigerio, Alessandro Mussida, Luisa Barzon, Alessandro Sinigaglia, Silvia Riccetti, Federico Gobbi, Chiara Piubelli, Greta Bergamaschi, Marcella Chiari, Alessandro Gori, Marina Cretich   +11 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

B-cell epitope mapping of Orthoflavivirus zikaense in mother-newborn immune interaction reveals postnatal immune signatures. [PDF]

Sci Rep
Soares AP, Chávez-Olórtegui C, de Lima Neto DF, Dos Passos Cunha M, Grillo TC, da Silva MF, Silva ACB, Bertozzi APAP, Bonafé CFS, Passos SD, de Andrade Zanotto PM.   +10 more
europepmc   +1 more source