Results 181 to 190 of about 100,019 (301)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Epitope Mapping of <i>Senecavirus A</i> 3A Protein Using Monoclonal Antibodies. [PDF]

Transbound Emerg Dis
Meng L, Tian XX, Xiang XY, Qi XY, Zhou HR, Xiao PY, An TQ, Meng FD, Wang HW.   +8 more
europepmc   +1 more source

Hydrogen-Deuterium Exchange Epitope Mapping of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase. [PDF]

Anal Chem, 2023
O'Leary TR, Balasubramaniam D, Hughes K, Foster D, Boyles J, Coleman K, Griffin PR.   +6 more
europepmc   +1 more source

Characterization of antibodies for osteopontin fragments in rheumatoid arthritis [PDF]

, 2008
Sharif, Shadi
core   +1 more source

AI-Driven Structural Mapping of Thyroid Autoantigens Reveals High-Confidence Conformational Epitopes for Precision Immunotherapy [PDF]

Luis Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Osmario Jorge De Mattos Salles, Jonh Menezes Leahy Neto, Luis Matos de Oliveira   +5 more
openalex   +1 more source

Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies [PDF]

, 1991
Jiake Xu, Miroslaw K. Górny, T J Palker, S Karwowska, Susan Zolla‐Pazner   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Residue 301-dependent epitope mapping reveals the molecular basis for GPV/MDPV serotype discrimination by neutralizing monoclonal antibody D1. [PDF]

Vet Res
Xiao S, Zhu X, Zheng M, Jiang D, Zheng C, Cheng X, Wang S, You G, Chen S, Chen S.   +9 more
europepmc   +1 more source

Epitope Mapping and In Silico Characterization of Interactions between Der p 7 Allergen and MoAb WH9

, 2013
Hsiao-Yun Tai, Jia-Kai Zhou, Hong Chou, Ming F. Tam, Yu-Sen Chen, Sheh‐Yi Sheu, Horng-Der Shen   +6 more
openalex   +2 more sources