Results 301 to 310 of about 1,474,718 (406)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Mammalian cell display with automated oligo design and library assembly allows for rapid residue level conformational epitope mapping. [PDF]

Commun Biol
Thalén NB, Karlander M, Lundqvist M, Persson H, Hofström C, Turunen SP, Godzwon M, Volk AL, Malm M, Ohlin M, Rockberg J.   +10 more
europepmc   +1 more source

Epitope Mapping of the Laminin Molecule in Murine Skin Basement Membrane Zone: Demonstration of Spatial Differences in Ultrastructural Localization

, 1991
Yuji Horiguchi, Dale R. Abrahamson, Jo‐David Fine   +2 more
openalex   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Moderately neutralizing epitopes in nonfunctional regions dominate the antibody response to Plasmodium falciparum EBA-140 [PDF]

, 2019
Adhikari, Jagat, Gross, Michael L., Paing, May M., Salinas, Nichole D., Tolia, Niraj   +4 more
core   +1 more source

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. [PDF]

, 2015
Alam, SM, Blair, L, Chao, A, Cocklin, SL, Dennison, SM, Duffy, R, Evans, A, Ferrari, G, Forthal, DN, Gao, F, Giorgi, EE, Haynes, BF, Kaewkungwal, J, Kim, JH, Klein, K, Korber, BT, Kumar, A, Landucci, G, Letvin, NL, Li, H, Liao, HX, Liu, P, Michael, NL, Montefiori, DC, Moody, MA, Moog, C, Nicely, NI, Nitayaphan, S, Pemble Iv, CW, Pitisuttithum, P, Pollara, J, Rerks-Ngarm, S, Robb, ML, Robinson, J, Santra, S, Schmitz, JE, Schutte, RJ, Shattock, RJ, Shaw, GM, Shen, X, Soderberg, KA, Tomaras, GD, Vidnovic, K, Warrier, R, Xia, SM, Zhang, R   +45 more
core   +1 more source

Epitope Mapping by Phage Display

Japanese Journal of Thrombosis and Hemostasis, 1998
Ichiro N. Maruyama, Ichiro Kuwabara
openaire   +2 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Sequence-based epitope mapping of high pathogenicity avian influenza H5 clade 2.3.4.4b in Latin America. [PDF]

Front Vet Sci
Ospina-Jimenez AF, Gomez AP, Osorio-Zambrano WF, Alvarez-Munoz S, Ramirez-Nieto GC.   +4 more
europepmc   +1 more source