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Proteolytic Fragmentation for Epitope Mapping
2003The use of antigen fragments generated by specific proteolytic cleavage is a relatively simple "library" approach for epitope mapping in which possible overlapping fragments are screened with the antibody on Western blots. Proteolytic fragmentation with numerous proteases having different cleavage specificites can be carried out on native and ...
MAZZONI, MARIA ROSA +2 more
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Journal of Agricultural and Food Chemistry, 2018
With the increased global awareness and rise in food allergies, a multifold interest in food allergens is evident. The presence of undeclared food allergens results in expensive food recalls and increased risks of anaphylaxis for the sensitive individuals.
Changqi Liu, Shridhar K. Sathe
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With the increased global awareness and rise in food allergies, a multifold interest in food allergens is evident. The presence of undeclared food allergens results in expensive food recalls and increased risks of anaphylaxis for the sensitive individuals.
Changqi Liu, Shridhar K. Sathe
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Mapping conformational epitopes by NMR spectroscopy
Current Opinion in Virology, 2021Antibodies recognize their target with high affinity and specificity. This is important for pathogen neutralization, which plays a crucial role in defense against disease. Antibodies are powerful tools in the development of new therapeutics, such as vaccines, to fight diseases such as viral infections and even cancer.
Ana P. Valente, Mariana Manzano-Rendeiro
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1998
Epitope mapping can be used to identify areas of a protein that an antibody recognizes and binds to. Monoclonal antibodies are easier to characterize, but epitope maps can also be produced for polyclonal antisera.
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Epitope mapping can be used to identify areas of a protein that an antibody recognizes and binds to. Monoclonal antibodies are easier to characterize, but epitope maps can also be produced for polyclonal antisera.
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2003
The majority of T cells recognize peptide epitopes bound to major histocompatibility complex (MHC)-encoded glycoproteins on the surface of professional antigen-presenting cells (APC), principally dendritic cells, macrophages, and B cells (1-3). Most T cells are specific for peptide epitopes in association with either classical MHC class Ia molecules ...
Alexei A. Delvig, John H. Robinson
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The majority of T cells recognize peptide epitopes bound to major histocompatibility complex (MHC)-encoded glycoproteins on the surface of professional antigen-presenting cells (APC), principally dendritic cells, macrophages, and B cells (1-3). Most T cells are specific for peptide epitopes in association with either classical MHC class Ia molecules ...
Alexei A. Delvig, John H. Robinson
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Epitope Mapping by Phage Display
2017Among the molecules of the immune system, antibodies, particularly monoclonal antibodies (mAbs), have been shown to be interesting for many biological applications. Due to their ability to recognize only a unique part of their target, mAbs are usually very specific.
Gustavo Marçal Schmidt Garcia Moreira +2 more
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Epitope mapping by solution NMR spectroscopy
Journal of Molecular Recognition, 2015Antibodies play an ever more prominent role in basic research as well as in the biotechnology and pharmaceutical sectors. Characterizing their epitopes, that is, the region that they recognize on their target molecule, is useful for purposes ranging from molecular biology research to vaccine design and intellectual property protection.
Bardelli M. +6 more
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Epitope Mapping of Human Alpha-Fetoprotein
Biochemistry (Moscow), 2001The epitope structure of human alpha-fetoprotein (AFP) was studied using more than 50 monoclonal antibodies (MAB) to human AFP. These MAB obtained from various world laboratories of the TD-2 AFP Workshops of the International Society for Oncodevelopmental Biology and Medicine (ISOBM-1996-1998-2000) were analyzed by competitive immunoaffinity ...
G.I. Abelev +3 more
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Mapping T cell epitopes by flow cytometry
Methods, 2003Epitope mapping by flow cytometry is a very modern approach that not only identifies T-cell epitopes but simultaneously allows for detailed analysis of the responding T-cell subsets including lineage, activation marker expression, and other markers of interest.
Hans-Dieter Volk +5 more
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Investigation of the epitopic structure of thymosin β10 by epitope mapping experiments
Peptides, 1999We present here a study on the epitopic structure and the immunochemical characteristics of thymosin beta10 (Tbeta10), a 43 aminoacid peptide involved in important cellular mechanisms, by using the epitope mapping Multipin method. Octapeptides overlapping by one amino acid so as to represent the whole sequence of Tbeta10 were synthesized on polystyrene
Gregory P. Evangelatos +5 more
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