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Epitope Mapping of Flavivirus Glycoproteins
1986Publisher Summary The vast majority of monoclonal antibodies to flaviviruses produced so far are specific for the E glycoprotein; therefore, this chapter deals with the characteristics of epitopes on this immunologically dominant protein. In addition, recent studies with NV3-specific monoclonal antibodies provide evidence that this nonstructural ...
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Mapping the autoimmunizing epitopes on acetylcholine receptors
Immunology Today, 1987In the autoimmune disease myasthenia gravis (MG), patients experience muscle weakness and fatiguability owing to loss of functional acetylcholine receptors (AChR) at the neuromuscular junction. The loss may be caused by modulation of the receptors by anti-AChR autoantibody and/or by complement-mediated focal lysis at the post-synaptic membrane.
GC Harcourt, Andy Jermy
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2003
Monoclonal and polyclonal antibodies are important tools in molecular and cell biology, allowing protein molecules to be purified (1), identified in immunoblots of gels (2) and sections of biological material (3), and probed for functionally active regions.
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Monoclonal and polyclonal antibodies are important tools in molecular and cell biology, allowing protein molecules to be purified (1), identified in immunoblots of gels (2) and sections of biological material (3), and probed for functionally active regions.
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Mapping epitopes on protein surfaces [PDF]
Biopolymers, 1995 Riccardo Cortese +2 more
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Mapping of Discontinuous Epitopes on FSH
2001The majority of protein-interaction sites are discontinuous, this means that various loops form the three-dimensional binding pocket. For proteins with unknown sequence and structure random libraries can be used to define the interaction site [1]. Proteins with a defined sequence and/or structure can be scanned with overlapping peptides against, for ...
Jerry W. Slootstra +3 more
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Mapping Protein Functional Epitopes
2005Essentially all events in biology require one molecule binding to another. With molecular recognition at the heart of biology, a number of phage-display-based techniques have been developed to dissect the details governing binding events. This chapter reviews phage-display applications that provide scalpels and microscopes to explore molecular ...
Sara K. Avrantinis, Gregory A. Weiss
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Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Nature, 2022Vassily Trubetskoy +2 more
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A systemic approach to mapping participation with low-carbon energy transitions
Nature Energy, 2021Jason Chilvers +2 more
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