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Epitope Mapping by Phage Display
Methods in molecular biology, 2017Among the molecules of the immune system, antibodies, particularly monoclonal antibodies (mAbs), have been shown to be interesting for many biological applications. Due to their ability to recognize only a unique part of their target, mAbs are usually very specific.
Gustavo Marçal Schmidt Garcia Moreira +2 more
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High-Throughput Epitope Mapping by Hydrogen Exchange-Mass Spectrometry.
Journal of the American Society for Mass Spectrometry, 2022In this paper, we introduce a screening protocol for epitope mapping by hydrogen exchange mass spectrometry (HX-MS) that has higher throughput than a traditional HX-MS epitope mapping.
H. M. E. Haque, N. Mantis, D. Weis
semanticscholar +1 more source
Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C44Mab-46) Using the REMAP Method.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 2021CD44 functions as a major hyaluronan receptor on most cell types, with roles in cell adhesion, migration, proliferation, differentiation, and survival. The CD44 gene comprises 20 exons, with alternative splicing producing many different isoforms.
Teizo Asano +4 more
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Epitope Mapping of an Antihuman EGFR Monoclonal Antibody (EMab-134) Using the REMAP Method.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 2021The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that plays an important role in normal epidermal cell physiology. EGFR is overexpressed in cancer cells and has a number of mutations that implicate tumor malignancy, development ...
M. Sano +3 more
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Monoclonal antibodies in immunodiagnosis and immunotherapy, 2021
The classic method for identifying the epitope that monoclonal antibodies (mAbs) bind uses deletion mutants and point mutants of the target protein. However, determining the epitope of mAbs-reactive membrane proteins is often challenging.
Ren Nanamiya +10 more
semanticscholar +1 more source
The classic method for identifying the epitope that monoclonal antibodies (mAbs) bind uses deletion mutants and point mutants of the target protein. However, determining the epitope of mAbs-reactive membrane proteins is often challenging.
Ren Nanamiya +10 more
semanticscholar +1 more source
Annals of Allergy, Asthma & Immunology, 2009
To provide a general overview of T-cell epitope mapping and its relevance to physicians practicing allergy/ immunology.The PubMed database was searched for articles published from January 1, 1990, through December 31, 2008, for primary and review articles on T-cell epitope mapping. The keywords searched were CD4 T cell, major histocompatibility complex
Raija K. Ahmed, Markus Maeurer
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To provide a general overview of T-cell epitope mapping and its relevance to physicians practicing allergy/ immunology.The PubMed database was searched for articles published from January 1, 1990, through December 31, 2008, for primary and review articles on T-cell epitope mapping. The keywords searched were CD4 T cell, major histocompatibility complex
Raija K. Ahmed, Markus Maeurer
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2003
An epitope is defined as the site on an antigen at which an antibody binds. In the case of proteins the epitopes can be classified as continuous (or sequential) and discontinuous according to whether or not the amino acids recognized are close together in the primary sequence or are well-separated but brought together by the folding of the protein. The
J E, Heckels, M, Christodoulides
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An epitope is defined as the site on an antigen at which an antibody binds. In the case of proteins the epitopes can be classified as continuous (or sequential) and discontinuous according to whether or not the amino acids recognized are close together in the primary sequence or are well-separated but brought together by the folding of the protein. The
J E, Heckels, M, Christodoulides
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Methods of epitope mapping [PDF]
Molecular Biology Reports, 1992 It is important to remember that the merits of the different approaches to epitope mapping should be judged against the purpose of the study. A peptide specifically recognized by nearly all sera containing a certain autoimmune specificity [20, 21, 26], would most likely be selected for the detection of the anti-linear/continuous epitope fraction among ...
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Epitope mapping of human thyrotropin [PDF]
Acta Endocrinologica, 1989 Abstract. Epitope mapping of hTSH was carried out using 19 monoclonal antibodies prepared with hTSH or its β-subunit as antigen. The affinity constants of the monoclonal antibodies ranged from 9.6 × 107 to 5.7 × 109 mol/l for hTSH. The binding activities of monoclonal antibodies were maintained or in some cases rather enhanced after removal of the ...
Toshihiro Nakajima +6 more
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Computational Epitope Mapping [PDF]
, 2009 Despite its unequivocal benefits to humankind, vaccine design and development has always been an inherently laborious and a largely empirical process; the unfortunate lack of a rational basis for vaccinology has hitherto stymied the commercial exploitation of vaccine discovery and also the deployment of vaccination as the principal, global instrument ...
Darren R. Flower, Matthew N. Davies
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