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Investigation of the epitopic structure of thymosin β10 by epitope mapping experiments
Peptides, 1999We present here a study on the epitopic structure and the immunochemical characteristics of thymosin beta10 (Tbeta10), a 43 aminoacid peptide involved in important cellular mechanisms, by using the epitope mapping Multipin method. Octapeptides overlapping by one amino acid so as to represent the whole sequence of Tbeta10 were synthesized on polystyrene
Gregory P. Evangelatos +5 more
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Research advances in hydrogen–deuterium exchange mass spectrometry for protein epitope mapping
Analytical and Bioanalytical Chemistry, 2021Haofeng Sun +6 more
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Mapping the autoimmunizing epitopes on acetylcholine receptors
Immunology Today, 1987In the autoimmune disease myasthenia gravis (MG), patients experience muscle weakness and fatiguability owing to loss of functional acetylcholine receptors (AChR) at the neuromuscular junction. The loss may be caused by modulation of the receptors by anti-AChR autoantibody and/or by complement-mediated focal lysis at the post-synaptic membrane.
GC Harcourt, Andy Jermy
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Epitope Mapping of Flavivirus Glycoproteins
1986Publisher Summary The vast majority of monoclonal antibodies to flaviviruses produced so far are specific for the E glycoprotein; therefore, this chapter deals with the characteristics of epitopes on this immunologically dominant protein. In addition, recent studies with NV3-specific monoclonal antibodies provide evidence that this nonstructural ...
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2003
Monoclonal and polyclonal antibodies are important tools in molecular and cell biology, allowing protein molecules to be purified (1), identified in immunoblots of gels (2) and sections of biological material (3), and probed for functionally active regions.
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Monoclonal and polyclonal antibodies are important tools in molecular and cell biology, allowing protein molecules to be purified (1), identified in immunoblots of gels (2) and sections of biological material (3), and probed for functionally active regions.
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Mapping epitopes on protein surfaces [PDF]
Biopolymers, 1995 Riccardo Cortese +2 more
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Mapping of Human T-Cell Epitopes of Allergens
2008Allergens are characterized by their ability to be bound by gE. The Swiss-Prot protein database currently lists a partial or complete amino acid sequence of in excess of about 350 allergens. It is not clear how allergens participate in the process of allergic sensitization, the generation of specific T-helper type 2 (Th2) lymphocytes, which play a ...
Thomas Zeiler, Tuomas Virtanen
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Mapping of Discontinuous Epitopes on FSH
2001The majority of protein-interaction sites are discontinuous, this means that various loops form the three-dimensional binding pocket. For proteins with unknown sequence and structure random libraries can be used to define the interaction site [1]. Proteins with a defined sequence and/or structure can be scanned with overlapping peptides against, for ...
Jerry W. Slootstra +3 more
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Epitope Mapping by Surface Plasmon Resonance
2009Biacore systems (Biacore AB) enable label-free detection of molecular interactions in real time using surface plasmon resonance detection. Epitope mapping of antibodies is usually performed in a pairwise fashion where one antibody is used to capture the antigen from solution and the binding of a secondary antibody is monitored.
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