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Annual Review of Immunology, 2020
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes. Identifying such epitopes enables tracking, phenotyping, and stimulating T cells involved in immune responses in infectious disease, allergy, autoimmunity ...
Morten Nielsen +4 more
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Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes. Identifying such epitopes enables tracking, phenotyping, and stimulating T cells involved in immune responses in infectious disease, allergy, autoimmunity ...
Morten Nielsen +4 more
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2003
An epitope is defined as the site on an antigen at which an antibody binds. In the case of proteins the epitopes can be classified as continuous (or sequential) and discontinuous according to whether or not the amino acids recognized are close together in the primary sequence or are well-separated but brought together by the folding of the protein. The
J E, Heckels, M, Christodoulides
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An epitope is defined as the site on an antigen at which an antibody binds. In the case of proteins the epitopes can be classified as continuous (or sequential) and discontinuous according to whether or not the amino acids recognized are close together in the primary sequence or are well-separated but brought together by the folding of the protein. The
J E, Heckels, M, Christodoulides
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Annual Review of Genetics, 1998
▪ Abstract Epitope tagging is a recombinant DNA method by which a protein encoded by a cloned gene is made immunoreactive to a known antibody. This review discusses the major advantages and limitations of epitope tagging and describes a number of recent applications.
J W, Jarvik, C A, Telmer
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▪ Abstract Epitope tagging is a recombinant DNA method by which a protein encoded by a cloned gene is made immunoreactive to a known antibody. This review discusses the major advantages and limitations of epitope tagging and describes a number of recent applications.
J W, Jarvik, C A, Telmer
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Molecular Biotechnology, 1994
Monoclonal antibodies (MAbs) are specific immunological tools because they bind to a precise determinant (the epitope) on the surface of a protein. The procedure of identifying the binding site of a MAb is often termed "epitope mapping."
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Monoclonal antibodies (MAbs) are specific immunological tools because they bind to a precise determinant (the epitope) on the surface of a protein. The procedure of identifying the binding site of a MAb is often termed "epitope mapping."
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Hypervariable epitope constructs as a means of accounting for epitope variability
Vaccine, 1994Epitope variability is one of the greatest obstacles to development of synthetic peptide vaccines. Based on a recently described hypervariable epitope (aa 414-434) on the envelope glycoprotein (gp130) to simian immunodeficiency virus (SIVmac142), we have developed a novel approach to account for epitope variability.
Arthur Malley +4 more
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Immunoglobulin Epitopes in Primates
Vox Sanguinis, 1979Abstract. Non‐human primate sera were investigated for the presence of various human immunoglobulin epitopes including allotypes of ϰ‐, γ1‐, γ2‐, γ3‐ and α2‐chains, isotypes of ϰ‐, γ1‐, γ2‐, γ3‐, γ4‐, α1‐, α2‐ and μ‐chains and iso‐allotypes. The non‐human primate sera comprised representatives of several species of apes, Old World monkeys, New World ...
Erna van Loghem, Gerda de Lange
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Annals of Allergy, Asthma & Immunology, 2009
To provide a general overview of T-cell epitope mapping and its relevance to physicians practicing allergy/ immunology.The PubMed database was searched for articles published from January 1, 1990, through December 31, 2008, for primary and review articles on T-cell epitope mapping. The keywords searched were CD4 T cell, major histocompatibility complex
Raija K. Ahmed, Markus Maeurer
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To provide a general overview of T-cell epitope mapping and its relevance to physicians practicing allergy/ immunology.The PubMed database was searched for articles published from January 1, 1990, through December 31, 2008, for primary and review articles on T-cell epitope mapping. The keywords searched were CD4 T cell, major histocompatibility complex
Raija K. Ahmed, Markus Maeurer
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T-Cell Epitope Processing (The Epitope Flanking Regions Matter)
2009Epitopes presented by major histocompatibility complex (MHC) class I molecules for cytotoxic T-lymphocyte (CTL) recognition are derived mainly from cytosolic proteins. Antigen presentation on the cell surface requires correct processing of epitopes by the proteasome, cytosolic and endoplasmic reticulum (ER) aminopeptidases, efficient TAP transport, and
Alejandra Nacarino Martinez +2 more
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The Structure of T-Cell Epitopes
Annual Review of Immunology, 1987We have reviewed here studies using synthetic peptides to analyze some of the properties of T-cell epitopes. Several general conclusions can be drawn. First, T-cell epitopes can usually be defined by linear sequences of about seven amino acids. However, the observation that increasing peptide length often results in increased antigenic potency has ...
and A M Livingstone, C G Fathman
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1998
Epitope mapping can be used to identify areas of a protein that an antibody recognizes and binds to. Monoclonal antibodies are easier to characterize, but epitope maps can also be produced for polyclonal antisera.
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Epitope mapping can be used to identify areas of a protein that an antibody recognizes and binds to. Monoclonal antibodies are easier to characterize, but epitope maps can also be produced for polyclonal antisera.
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