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Prediction of Antibody Epitopes
2015Antibodies recognize their cognate antigens in a precise and effective way. In order to do so, they target regions of the antigenic molecules that have specific features such as large exposed areas, presence of charged or polar atoms, specific secondary structure elements, and lack of similarity to self-proteins.
Morten Nielsen +2 more
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Blood, 2008
To the editor: The FMC7 antibody, originally described in 1981,[1][1] detects an antigen expressed on mature human B cells and is used in immunophenotypic analysis and differential diagnosis of lymphomas and leukemias. The identity of the FMC7 antigen was unclear for many years.
Julie P. Deans, Maria J. Polyak
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To the editor: The FMC7 antibody, originally described in 1981,[1][1] detects an antigen expressed on mature human B cells and is used in immunophenotypic analysis and differential diagnosis of lymphomas and leukemias. The identity of the FMC7 antigen was unclear for many years.
Julie P. Deans, Maria J. Polyak
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An Introduction to Epitope Mapping
2018Antibodies are protein molecules used routinely for therapeutic, diagnostic, and research purposes due to their exquisite ability to selectively recognize and bind a given antigen. The particular area of the antigen recognized by the antibody is called the epitope, and for proteinaceous antigens the epitope can be of complex nature.
Johan Rockberg, Johan Nilvebrant
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2016
The original scientific strategy behind vaccinology has historically been to “isolate, inactivate, and inject,” first invoked by Louis Pasteur. Subsequently, this empirical approach dominated the vaccine development over 80 years. The recombinant DNA technology arised, and in 1980 the first recombinant vaccine against hepatitis B virus was presented ...
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The original scientific strategy behind vaccinology has historically been to “isolate, inactivate, and inject,” first invoked by Louis Pasteur. Subsequently, this empirical approach dominated the vaccine development over 80 years. The recombinant DNA technology arised, and in 1980 the first recombinant vaccine against hepatitis B virus was presented ...
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2009
The current challenge in synthetic vaccine design is the development of a methodology to identify and test short antigen peptides as potential T cell epitopes. A HLA-peptide binding model (using structural properties) capable of predicting peptides binding to any HLA allele has been described in Chap. 7.
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The current challenge in synthetic vaccine design is the development of a methodology to identify and test short antigen peptides as potential T cell epitopes. A HLA-peptide binding model (using structural properties) capable of predicting peptides binding to any HLA allele has been described in Chap. 7.
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Cryptic epitope and autoimmunity
Diabetes / Metabolism Reviews, 1998Micheal S. Lan, Noel K. Maclaren
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2014
Modem immunology and vaccinology incorporate immunoinformatics techniques to give insights into immune systems and accelerate vaccine design. Databases managing epitope data in a structured form with immune-related annotations including sequences, alleles, source organisms, structures, and diseases could be the most crucial part of immunoinformatics ...
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Modem immunology and vaccinology incorporate immunoinformatics techniques to give insights into immune systems and accelerate vaccine design. Databases managing epitope data in a structured form with immune-related annotations including sequences, alleles, source organisms, structures, and diseases could be the most crucial part of immunoinformatics ...
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2017
An epitope is a part of an immunogenic protein that can be recognized by the immune system. The peptides that can be recognized by the T-cell receptors after a particular antigen has been intracellularly processed, bound to at least one MHC molecule and expressed on the surface of the antigen presenting cell as a MHC-peptide complex, are called a T ...
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An epitope is a part of an immunogenic protein that can be recognized by the immune system. The peptides that can be recognized by the T-cell receptors after a particular antigen has been intracellularly processed, bound to at least one MHC molecule and expressed on the surface of the antigen presenting cell as a MHC-peptide complex, are called a T ...
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Prediction of continuous B‐cell epitopes in an antigen using recurrent neural network
Proteins: Structure, Function, and Bioinformatics, 2006S. Saha, Gajendra P. Raghava
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