Results 51 to 60 of about 343,320 (257)

Preparation and Identification of a Monoclonal Antibody against the Pseudorabies Virus gE Glycoprotein through a Novel Strategy

Veterinary Sciences, 2023
Since 2011, pseudorabies virus (PRV) has recurred in several vaccinated pig farms in China. PRV variants with high virulence were found to be the main cause of the outbreaks.
Zhenyang Guo, Siyu Zhang, Hu Xu, Wansheng Li, Chao Li, Jing Zhao, Bangjun Gong, Qi Sun, Lirun Xiang, Hongyuan Zhao, Qian Wang, Guohui Zhou, Yandong Tang, Tongqing An, Xuehui Cai, Zhijun Tian, Hongliang Zhang, Jinmei Peng   +17 more
doaj   +1 more source

Active Learning Framework for Cost-Effective TCR-Epitope Binding Affinity Prediction [PDF]

arXiv, 2023
T cell receptors (TCRs) are critical components of adaptive immune systems, responsible for responding to threats by recognizing epitope sequences presented on host cell surface. Computational prediction of binding affinity between TCRs and epitope sequences using machine/deep learning has attracted intense attention recently.
arxiv  

Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]

, 2013
John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D, Gong, Lizhi Ian, Suchard, Marc A   +2 more
core   +1 more source

A Novel Algorithm for Macromolecular Epitope Matching

Algorithms, 2009
Many macromolecules, namely proteins, show functional substructures or epitopes defined by characteristic spatial arrangements of groups of specific atoms or residues.
Stanislav Jakuschev, Daniel Hoffmann
doaj   +1 more source

B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development

Viruses, 2023
Failure of cross-protection among interserotypes and intratypes of foot-and-mouth disease virus (FMDV) is a big threat to endemic countries and their prevention and control strategies.
Qian Li, Ashenafi Kiros Wubshet, Yang Wang, Livio Heath, Jie Zhang   +4 more
doaj   +1 more source

Uncertainty Estimation in SARS-CoV-2 B-cell Epitope Prediction for Vaccine Development [PDF]

arXiv, 2021
B-cell epitopes play a key role in stimulating B-cells, triggering the primary immune response which results in antibody production as well as the establishment of long-term immunity in the form of memory cells. Consequently, being able to accurately predict appropriate linear B-cell epitope regions would pave the way for the development of new protein-
arxiv  

Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model. [PDF]

, 2008
Lipid transfer proteins (LTPs) are the major allergens of Rosaceae fruits in the Mediterranean area. Pru p 3, the LTP and major allergen of peach, is a suitable model for studying food allergy and amino acid sequences related with its IgE-binding ...
Compes, Esther, Cuesta-Herranz, Javier, Díaz Perales, Araceli, Pacios, Luis F., Palacín Gómez, Aranzazu, Salcedo Duran, Gabriel, Sánchez-Monge Laguna de Rins, Rosa, Tordesillas Villuendas, Leticia   +7 more
core   +2 more sources

Defining the epichromatin epitope [PDF]

Nucleus, 2017
Epichromatin is identified by immunostaining fixed and permeabilized cells with particular bivalent anti-nucleosome antibodies (mAbs PL2-6 and 1H6). During interphase, epichromatin resides adjacent to the inner nuclear membrane; during mitosis, at the outer surface of mitotic chromosomes.
Travis J. Gould, Katalin Tóth, Norbert Mücke, Jörg Langowski, Alexandra S. Hakusui, Ada L. Olins, Donald E. Olins   +6 more
openaire   +3 more sources

Phage Display Detection of Mimotopes that Are Shared Epitopes of Clinically and Epidemiologically Relevant Enterobacteria

Microorganisms, 2020
Background: Escherichia coli and Salmonella are etiologic agents of intestinal infections. A previous study showed the presence of shared epitopes between lipopolysaccharides (LPSs) of E. coli O157 and Salmonella.
Armando Navarro, Delia Licona-Moreno, Alejandro Monsalvo-Reyes, Ulises Hernández-Chiñas, Carlos A. Eslava-Campos   +4 more
doaj   +1 more source

Analogue peptides for the immunotherapy of human acute myeloid leukemia [PDF]

, 2015
Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials.
A Driessche Van, A Gros, A Scardino, A Serrano, A Sevko, A Snyder, A Tsuboi, AB Bakker, Aleksandrs Malinovskis, Andrew Mead, AT Cheuk, AW Purcell, B Engels, B Falini, B Maecker, B Maecker, B Uttenthal, BA Guinn, BA Guinn, Barbara-ann Guinn, C Chaise, C Maccalli, CL Slingluff Jr, D Cilloni, D Mason, DA Gross, DE Speiser, DH Chang, DJ Schwartzentruber, E Estey, E Romano, F Ghiringhelli, FS Hodi, G Khan, H Kobayashi, H Ohminami, HJ Kolb, HJ Stauss, I Bellantuono, J Bae, J Bae, J Fourcade, J Greiner, J Greiner, J Kronke, J Pinilla-Ibarz, J Pinilla-Ibarz, JH Sampson, JJ Molldrem, JL Chen, JL Chen, JN Kochenderfer, JS Ko, JW Wells, K Inoue, K Inoue, K Rezvani, K Rezvani, KM Zirlik, L Chan, L Fong, L Gao, LV Ly, M Harndahl, M Kapp, M Subklewe, MA Cheever, MG Warnock, MM Gubin, MR Parkhurst, MS Bijker, N Hardwick, Nicola R. Hardwick, O Christensen, O Hamid, P Brossart, P Bruggen van der, P Keskinen, PG Maslak, PG Maslak, R Cibotti, RA Padua, RF Schlenk, RJ May, S Frankild, S Hofmann, S Narayan, S Ochsenreither, S Pascolo, S Suekane, S Walter, SH Burg van der, SK Singh, SL Topalian, SP Adams, Susanne Hofmann, T Lovgren, U Keilholz, U Sahin, V Bhardwaj, WS Meng, Y Oka, Z Trajanoski   +102 more
core   +1 more source