Results 211 to 220 of about 5,392 (239)

Epitranscriptomics: mixed messages

Nature Methods, 2017
Pioneering mapmakers have uncovered a surprising variety of abundant RNA modifications that have an apparently critical—but still poorly understood—role in gene regulation.
openaire   +1 more source

Direct RNA sequencing of the Escherichia coli epitranscriptome uncovers alterations under heat stress

bioRxiv
Modifications of RNA, known as the epitranscriptome, affect gene expression, translation, and splicing in eukaryotes, with implications for developmental processes, cancer, and viral infections.
Sebastian Riquelme Barrios, L. Camus, Siobhan A. Cusack, Korinna Burdack, D. P. Petrov, G. N. Yeşiltaç-Tosun, Stefanie M. Kaiser, Pascal Giehr, Kirsten Jung   +8 more
semanticscholar   +1 more source

Directed evolution of an m6A eraser for site-selective epitranscriptome editing

Research Square
N6-methyladenosine (m6A) is a critical RNA modification, but tools to manipulate it in cells remain limited. Current m6A demethylases (FTO and ALKBH5) exhibit low catalytic efficiency, hindering their applications in epitranscriptomic research and ...
Huiqing Zhou, Chuan-Hui Wang
semanticscholar   +1 more source

Ψ-Atlas: an integrated atlas for pseudouridine epitranscriptome

bioRxiv
Pseudouridine (Ψ) is a C5 glycoside isomer of uridine, formed by breaking the N1 glycosyl bond and undergoing a 180° base rotation. This modification stands as one of the most widespread post-transcriptional alterations in RNA and is universally ...
Xiaochen Wang, Jinjing Luo, Xiaoqiang Lang, Yongqing Ling, Yiming Zhou, Guoxian Liu, Xiangye Chen, Yibo Chen, Yingshun Zhou, Yi Cao, Zhonghui Zhang, Changjun Ding, Demeng Chen, Qi Liu   +13 more
semanticscholar   +1 more source

Abstract 3337: Unveiling m6A epitranscriptome-related genomic variations in bladder cancer: predictive biomarkers for disease progression and treatment outcome towards tailored therapeutics

Cancer Research
Due to its highly heterogenous molecular landscape, bladder cancer (BlCa) is still characterized by non-personalized prognosis and treatment decisions.
Andreas Scorilas, Katerina-Marina Pilala, P. Tsiakanikas, K. Panoutsopoulou, M. Papadimitriou, Konstantinos Soureas, Georgios-Christos Giagkos, Panagiotis Levis, Georgios Kotronopoulos, Z. Kanaki, Ioannis Prassas, Lampros Dimitrakopoulos, George M. Yousef, Konstantinos Stravodimos, Stiliani Koroneou, M. Avgeris   +15 more
semanticscholar   +1 more source

Deciphering the Epitranscriptome in Cancer

Trends in Cancer, 2018
Technological and methodological advancements have recently revolutionized our understanding of widespread epitranscriptome including RNA modifications and editing. N6-methyladenosine (m6A) represents the most prevalent internal modification in mammalian RNAs. Adenosine to inosine (A-to-I) RNA editing is an important mechanism underlying RNA generation
Hao, Lian, Qin-Hua, Wang, Chang-Bin, Zhu, Jie, Ma, Wei-Lin, Jin   +4 more
openaire   +2 more sources

YTHDF3 at the crossroads of the Epitranscriptome: Structure, networks, and disease roles.

Cellular Signalling
N6-methyladenosine (m6A) is the predominant internal RNA modification that programs RNA splicing, stability, translation, and decay through writer, eraser, and reader proteins.
Kai Yu, Jiazhu Sun, Yuchen Shi, Jiawei Zhang, Ben Liu   +4 more
semanticscholar   +1 more source

EXPLORING THE GLIOMA M6A RNA EPITRANSCRIPTOME WITH DIRECT RNA SEQUENCING

Neuro-Oncology
Despite aggressive treatment, glioblastoma patients suffer from an invariably poor prognosis. Whilst substan- tial progress has been made in understanding the role of DNA methylation in brain tumour pathology, methy- lation of RNA has received ...
Simon Deacon, M. Radhi, Lauryn Walker, J. Rowlinson, S. Paine, M. Loose, Stuart Smith   +6 more
semanticscholar   +1 more source

Epitranscriptome‐Mediated Regulation of Neuronal Translation

Wiley Interdisciplinary Reviews - RNA
Epitranscriptomic modification of RNA is an important layer of regulation for gene expression. RNA modifications come in many flavors and generate a complex tapestry of a regulatory network. Here, we focus on two major RNA modifications, one on rRNA (2′O
Syed Wasifa Qadri, Nisa Manzoor Shah, Ravi S Muddashetty   +2 more
semanticscholar   +1 more source

m6AConquer: a consistently quantified and orthogonally validated database for the N6-methyladenosine (m6A) epitranscriptome

Nucleic Acids Research
The proper placement of N6-methyladenosine (m6A) on mRNA is essential for normal cell function, and its disruption is linked to numerous human diseases. The rapid growth of m6A data from diverse sequencing technologies presents challenges for integrative
Xichen Zhao, Haokai Ye, Dan He, Hongxi Liu, Tenglong Li, Daniel J. Rigden, Zhen Wei   +6 more
semanticscholar   +1 more source