Results 121 to 130 of about 44,698 (310)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Serum erythropoietin level is increased during stimulation for IVF but not in OHSS

Reproductive Biology and Endocrinology
Background Erythropoietin (Epo) is a potent vascular growth factor that induces angiogenesis and antiapoptotic signalling. We investigated whether the development of numerous follicles and corpora lutea during in vitro fertilization (IVF) cycle affects ...
Merituuli Rekola, Kati Korhonen, Leila Unkila-Kallio, Henrik Alfthan, Vedran Stefanovic, Aila Tiitinen, Tomi S. Mikkola, Hanna Savolainen-Peltonen   +7 more
doaj   +1 more source

Constitutive lentiviral expression of Epo.

, 2013
Wistar rats were injected with CMV Epo (n = 11) or vehicle (n = 2) at t = 0. A sustained elevated hematocrit was observed in all CMV Epo injected animals.
David M. Markusic (321628), Dirk R. de Waart (365883), Jurgen Seppen (8960)   +2 more
core   +1 more source

Parental involvement and engagement during COVID‐19 lockdowns: School staff and parents' reflections about children's learning at home

British Educational Research Journal, EarlyView.
Abstract Valuing parental engagement, as part of home–school collaboration, can benefit children's learning. This article focuses on parents and school‐based staff's (N = 120) experiences of children's learning occurring at home during the COVID‐19 lockdowns (2020–2021), both school‐mandated and other learning activities.
Ashley Brett, Bonny L. Hartley, Deborah Wallace, Adewale Magaji, Lorraine Smith, Rachel Wolfendale   +5 more
wiley   +1 more source

Environmental Psychology Open: Opening new doors for environmental psychology

Umweltpsycholog:innen untersuchen, wie sich die natürliche und gebaute Umwelt auf psychologische Prozesse sowie das menschliche Verhalten auswirken (Gifford, 2014).
Hanß, Daniel, Hofmann, Mathias, Röderer, Kathrin, Lange, Florian   +3 more
core  

Epo controls Lyn expression.

, 2013
A: Lyn and EpoR expression were studied in 633, 663 and 812 cells continuously grown in the presence of either Epo (1 U/mL) or SCF (100 ng/mL). Whole cell lysates were subjected to Western blot analysis with antibodies directed against Lyn, EpoR and β ...
Dorothée Buet (372524), Françoise Moreau-Gachelin (300121), Isabelle Gallais (300118), Nicole Denis (300119), Olivier Kosmider (372523)   +4 more
core   +1 more source

Effective methods for increasing levels of political self‐efficacy for girls and disadvantaged students in England

British Educational Research Journal, EarlyView.
Abstract This study addresses the gap in rigorous evaluation of inclusive Citizenship Education methods in reducing gender and socioeconomic inequalities in political self‐efficacy. This article tests the effectiveness of two pedagogical approaches: counter‐narratives and think‐pair‐share.
Bryony Hoskins, Khuyen Dinh, Christian Christrup Kjeldsen   +2 more
wiley   +1 more source

CIP stimulates EPO mRNA expression.

, 2014
Mice received CI or Sham and were treated with daily, oral doses of CIP or Veh starting 2 hours after injury. Levels of EPO in sera, and EPO mRNA and HIF-1α in kidney were analyzed 10 days after CI.
Juliann G. Kiang (242541), Risaku Fukumoto (242542), True M. Burns (528777)   +2 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

ESG Performance, Debt Financing, and R&D Output: Evidence From the Healthcare Sector

Business Strategy and the Environment, EarlyView.
ABSTRACT Amid growing calls for sustainability in the healthcare sector, this study examines how and under what conditions environmental, social, and governance (ESG) performance influences research and development (R&D) output. Although existing studies suggest that ESG performance enhances R&D output, the financial mechanisms that enable or constrain
Sarmad Ali, Oriana Ciani, Simone Ghislandi   +2 more
wiley   +1 more source