Results 1 to 10 of about 173,009 (382)
Journal of Medicinal Chemistry, 2021 This report describes the development of an orally active analgesic that resolves inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts on the cytochrome P450 branch of the arachidonate cascade to stabilize epoxides of
B. Hammock +9 more
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An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease
Science Translational Medicine, 2020 Blocking epoxide hydrolase with a bioavailable small-molecule inhibitor reduces neuropathology in an Alzheimer’s disease mouse model. Dialing up epoxy fatty acids in the brain Neuroinflammation is strongly implicated in Alzheimer’s disease (AD).
A. Ghosh +7 more
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Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2023 The reaction mechanism of several Williamson‟s ether syntheses have been studied using density functional theory with triple-ζ basis sets. These computations show that the synthesis of geometrically-strained epoxide from deprotonated halohydrins is due ...
Pedro J. Silva
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The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease
International Journal of Molecular Sciences, 2020 Epoxide hydrolases (EHs) are key enzymes involved in the detoxification of xenobiotics and biotransformation of endogenous epoxides. They catalyze the hydrolysis of highly reactive epoxides to less reactive diols.
J. Gautheron, I. Jéru
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Deep Eutectic Solvents as Catalysts for Cyclic Carbonates Synthesis from CO2 and Epoxides
Molecules, 2022 In recent years, the chemical industry has put emphasis on designing or modifying chemical processes that would increasingly meet the requirements of the adopted proecological sustainable development strategy and the principles of green chemistry.
Dorota Mańka, Agnieszka Siewniak
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Green Pathway in Utilizing CO2 via Cycloaddition Reaction with Epoxide—A Mini Review
Processes, 2020 Carbon dioxide (CO2) has been anticipated as an ideal carbon building block for organic synthesis due to the noble properties of CO2, which are abundant renewable carbon feedstock, non-toxic nature, and contributing to a more sustainable use of resources.
K. Kiatkittipong +6 more
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In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols [PDF]
Royal Society Open Science, 2018 The flow coupling of epichlorohydrin with substituted phenols, while efficient, limits the nature of the epoxide available for the development of focused libraries of β-amino alcohols.
Peter J. Cossar +3 more
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Journal of Lipid Research, 2022 In light of the importance of epoxyeicosatrienoic acids (EETs) in mammalian pathophysiology, a nonenzymatic route that might form these monoepoxides in cells is of significant interest.
James A. Weiny +4 more
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Epoxide Syntheses and Ring-Opening Reactions in Drug Development
, 2020 This review concentrates on success stories from the synthesis of approved medicines and drug candidates using epoxide chemistry in the development of robust and efficient syntheses at large scale. The focus is on those parts of each synthesis related to
Fotini Moschona +4 more
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Gold Nanoparticle-Catalyzed Environmentally Benign Deoxygenation of Epoxides to Alkenes
Molecules, 2011 We have developed a highly efficient and green catalytic deoxygenation of epoxides to alkenes using gold nanoparticles (NPs) supported on hydrotalcite [HT: Mg6Al2CO3(OH)16] (Au/HT) with alcohols, CO/H2O or H2 as the reducing reagent.
Kiyotomi Kaneda +4 more
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