Results 111 to 120 of about 67,475 (292)

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe   +6 more
wiley   +1 more source

Benzo[a]pyrene Diol Epoxide and Bleomycin Sensitivity and Susceptibility to Cancer of Upper Aerodigestive Tract [PDF]

open access: bronze, 1998
Xifeng Wu   +9 more
openalex   +1 more source

Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis

open access: yesChemSusChem, Volume 18, Issue 6, March 15, 2025.
The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo   +4 more
wiley   +1 more source

An epoxide hydrolase from endophyticStreptomycesshows unique structural features and wide biocatalytic activity [PDF]

open access: hybrid, 2020
Gabriela D. Tormet‐González   +5 more
openalex   +1 more source

Pesticide Contamination in the Hair of Children From Colonia San Juan, a Rural Community in Paraguay

open access: yesDrug Testing and Analysis, EarlyView.
Hair analysis in children from a rural community in Paraguay reveals exposure to organophosphates, pyrethroids, neonicotinoids, fungicides, herbicides, and endocrine disruptors, highlighting the urgent need for stricter environmental protections and preventive health measures. ABSTRACT Chronic exposure to pesticides can cause carcinogenic, reproductive,
Stela Benitez Leite   +5 more
wiley   +1 more source

Fluoro‐Functionalized Polyether Electrolytes Enabling High‐Energy‐Density Solid‐State Lithium‐Metal Batteries

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Fluoro‐functionalized polyether electrolytes, which combine fluorine‐ and ether‐containing groups, achieve enhanced oxidative stability, high ionic conductivity, and superior interfacial stability. Due to their non‐flammability, remarkable flexibility, ease of processing, and design versatility, polymer‐based electrolytes containing polyethers have ...
Nannan Geng   +8 more
wiley   +1 more source

Ring Formation in Sesquiterpene Synthesis: Biomimetic vs. Non‐Biomimetic Strategies

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
A short review of cyclase enzyme‐mediated ring formation in sesquiterpene biosynthesis is presented as a prelude to six case studies examining the merits and demerits of biomimetic vs. non‐biomimetic strategies for carbocyclisation in the total synthesis of this iconic natural product class.
Bohan Lin, Chen Dai, Alan C. Spivey
wiley   +1 more source

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

open access: gold, 2021
Jérémie Gautheron   +16 more
openalex   +1 more source

Home - About - Disclaimer - Privacy