Results 121 to 130 of about 67,475 (292)

Integrated Anatomical, Chemical, Biological and Computational Studies Approach of Myrcia sylvatica (G. Mey) DC. A Multifaceted Insight Into a Promising Amazonian Species

open access: yesFlavour and Fragrance Journal, EarlyView.
This study presents an integrated anatomical, chemical, biological, and computational analysis of Myrcia sylvatica, revealing key bioactive compounds with antioxidant and toxicological potential, and identifying spathulenol and globulol as promising acetylcholinesterase inhibitors with favourable pharmacokinetic properties. ABSTRACT Myrcia sylvatica (G.
Eliza de Jesus Barros dos Santos   +10 more
wiley   +1 more source

Effect of Fruit Maturation Stage on the Chemical Composition and Antioxidant and Cytotoxic Activities of Piper nigrum Essential Oil

open access: yesFlavour and Fragrance Journal, EarlyView.
The essential oils of Piper nigrum show marked chemical and biological variation across fruit maturation stages. Ripe fruits yield oils with the strongest antioxidant and cytotoxic activities, demonstrating that maturation directly modulates volatile composition and enhances the bioactive potential of this aromatic species.
Marcio Marcelo da Siva Pessoa   +6 more
wiley   +1 more source

Occurrence and Human Health Implications of Legacy Organochlorine Pesticides and Their Metabolites in Fruits and Vegetables of Bangladesh

open access: yesFood Safety and Health, EarlyView.
Multiple OCP isomers and/or metabolites along with their parent compounds were detected in commonly consumed fruits and vegetables of Bangladesh, possibly attributed to both recently and historically applied OCPs. However, all the detected values were below 0.01 mg/kg, indicating no potential human health risks through dietary intake. ABSTRACT Globally,
Kazi Sanjana Adnen   +4 more
wiley   +1 more source

Transannular O‐Heterocyclization Reactions of Cyclododeca‐1,5,9‐triene Derivatives: A New Concept for the Preparation of Key Intermediates for Total Syntheses of Annonaceous Acetogenins

open access: yesHelvetica Chimica Acta, EarlyView.
Four stereogenic centers are formed diastereoselectively in one step from a cyclic (E,E)‐1,5‐diene system using an electrophilic addition reaction. Subsequent ozonolytic cleavage of the intact Z‐double bond, followed by intramolecular nucleophilic substitution, yields an octahydroterfurandione with a threo,cis,threo configuration, an arrangement found ...
Holger Schimanski   +6 more
wiley   +1 more source

Sulfur Ylides in Skeletal‐Editing—Ring Expansion Reactions

open access: yesHelvetica Chimica Acta, EarlyView.
Sulfur ylides (S‐ylides) are emergent diazo surrogates that enable skeletal editing and ring expansion with safer handling and broad functional group tolerance. This perspective covers pioneer works and highlights recent advances in the field, while outlining key challenges and future directions that may redefine the role of S‐ylides in modern ...
Arsala Kamal   +3 more
wiley   +1 more source

A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012

open access: yesJournal of Research in Medical Sciences, 2013
Background: Carbamazepine has been used as AEDs since 1965, and is most effective against partial seizures. Two basic mechanisms of action have been proposed: 1) enhancement of sodium channel inactivation by reducing high-frequency repetitive firing of ...
Zahra Tolou-Ghamari   +3 more
doaj  

Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells

open access: green, 2022
Steffen Brunst   +11 more
openalex   +2 more sources

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