Results 151 to 160 of about 171,687 (384)

Nanoparticles Functionalized with Polymer Brushes for Gene Delivery

Advanced NanoBiomed Research, EarlyView.
The engineering of the next generation gene delivery vectors requires the precise control of the architecture and physicochemical interactions controlling the transport, targeting, uptake, and release of nucleic acid materials to targeted cells. Polymer brush‐functionalized nanomaterials offer unprecedented control over such design and properties, and ...
Carlos E. Neri‐Cruz, Julien E. Gautrot
wiley   +1 more source

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Angewandte Chemie, EarlyView.
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar, Florian Leidner, Nivesh Kumar, Jared L. Hass, Peter Madzelan, Douglas R. Powell, Victor W. Day, Pierre Le Magueres, Joseph D. Ferrara, Lee M. Daniels, Akihito Yamano, Sho Ito, Wei Niu, Helmut Grubmüller, Mark A. Wilson, David B. Berkowitz   +15 more
wiley   +2 more sources

Reactions of primary amines with epoxides [PDF]

, 1962
John F. Harrod
openalex   +1 more source

Totalsynthese und Strukturkorrektur von (−)‐Sodagnitin E

Angewandte Chemie, EarlyView.
Das Malabarican‐Triterpen Sodagnitin E ist ein in verschiedenen Pilzen vorkommendes Chromogen. Die vorliegende Arbeit stellt sowohl die erste Totalsynthese von (−)‐Sodagnitin E als auch die erste Synthese eines Malabaricans überhaupt dar. Die konvergente Synthese basiert auf der Verknüpfung zweier enantioselektiv hergestellter Fragmente mittels ...
Philipp Schoch, Tanja Gaich
wiley   +1 more source

Die Umlenkung der Peptidspaltung führt zur Protease‐Inaktivierung

Angewandte Chemie, EarlyView.
Cysteinproteasen katalysieren die Substratspaltung im Zuge eines zweistufigen Acyltransfers. Die neuartigen peptidischen Inhibitoren von humanem Cathepsin B mit einer N‐terminalen Carbamat‐Kopfgruppe erfahren eine Umlenkung der Peptidspaltung und bilden nicht‐kanonische kovalente Komplexe.
Christian Breuer, Jim Küppers, Anna‐Christina Schulz‐Fincke, Anna Heilos, Carina Lemke, Petra Spiwoková, Janina Schmitz, Laura Cremer, Marta Frigolé‐Vivas, Michael Lülsdorff, Matthias D. Mertens, Filip Wichterle, Miloš Apeltauer, Martin Horn, Erik Gilberg, Norbert Furtmann, Jürgen Bajorath, Ulrike Bartz, Bernd Engels, Michael Mareš, Michael Gütschow   +20 more
wiley   +1 more source

5(S)-((3aR,4R,6aR)-2,2-Dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-phenyl-4,5-dihydrooxazole

Molbank
5(S)-((3aR,4R,6aR)-2,2-Dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-phenyl-4,5-dihydrooxazole was synthesized from isosorbide in a three-step sequence, with an overall yield of 46%.
Liliana Boiaryna, Stéphane Guillarme, Christine Saluzzo   +2 more
doaj   +1 more source

Utilization of oxygen difluoride for syntheses of fluoropolymers [PDF]

, 1976
The reaction oxygen difluoride, OF2, with ethylenically unsaturated fluorocarbon compounds is examined. Depending upon the fluorocarbon material and reaction conditions, OF2 can chain extend fluoropolyenes, convert functional perfluorovinyl groups to ...
Toy, M. S.
core   +1 more source

Reactions of p-Nitrophenyloxirane with Amines Containing Fragments with Bicyclic Skeleton [PDF]

, 2002
Reactions of p-nitrophenyloxirane with amines containing fragments with bicyclic skeleton of norbornene, norbornane, epoxynorbornane (stereoisomeric exo- and endo-5-aminomethylbicyclo[2.2.1]hept-2-enes, N-benzyl-endo-5-aminomethylbicyclo[2.2.1]hept-2-ene,
Golodaeva, E. A., Kas'yan, A. O., Kas'yan, L. I., Tsygankov, A. V.   +3 more
core  

News from Procter & Gamble...Now Three Epoxides to Help Solve Your Problems [PDF]

, 1964

openalex   +1 more source

Mechanisms for the Oxonolysis of Ethene and Propene: Reliability of Quantum Chemical Predictions [PDF]

, 2003
Reactions of ozone with ethene and propene leading to primary ozonide (concerted and stepwise ozonolysis) or epoxide and singlet molecular oxygen (partial ozonolysis) are studied theoretically.
Chan, Wai-To, Hamilton, Ian P.
core   +1 more source