Results 161 to 170 of about 171,687 (384)
The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Angewandte Chemie International Edition, Accepted Article.Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl +6 more
wiley +1 more source
Polymerization behavior of aziridines with 1,2‐epoxides [PDF]
, 1964 C. G. Overberger, Martin Tobkes
openalex +1 more source
Angewandte Chemie International Edition, Accepted Article.This study presents a phosgene‐ and isocyanate‐free route for the synthesis of polyurethanes using (R)‐limonene as a bio‐based starting material. The synthesis of the cyclic limonene‐based carbamate monomer LU is achieved in high yields using dimethyl carbonate as a sustainable, less hazardous phosgene surrogate and is verified by NMR, SC‐XRD, ESI‐MS ...
Jonas Futter +4 more
wiley +1 more source
Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors
Angewandte Chemie International Edition, Accepted Article.High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS’s ability to directly assess drug‐protein interactions at endogenous levels, particularly in subcellular contexts.
Shuqi Li +10 more
wiley +1 more source
Molbank(1S,1′S)-2,2′-(Benzylazanediyl)bis(1-((3aR,4R,6aR)-2,2-dimethyltetrahydrofuro [3,4 d][1,3]dioxol-4-yl)ethan-1-ol), presenting a tertiary β-aminodiol moiety, was synthesized in 72% yield in a one-step reaction from an aminolysis of an isosorbide-derived ...
Mohammed Kadraoui +2 more
doaj +1 more source
Properties of epoxide hydrolase from the yeast Rhodotorula glutinis [PDF]
Epoxide hydrolases are ubiquitous enzymes that can be found in nearly all living organisms. Some of the enzymes play an important role in detoxifying xenobiotic and metabolic compounds.
Ariës-Kronenburg, N.A.E.
core +1 more source
Total Synthesis and Structural Revision of (−)‐Sodagnitin E
Angewandte Chemie International Edition, EarlyView.Malabaricane triterpenoid sodagnitin E is a chromogen found in various toadstools. This work represents the first total synthesis of (−)‐sodagnitin E as well as the first total synthesis of any malabaricane natural product. A Mukaiyama aldol reaction was utilized to perform a convergent synthesis from two enantioselectively synthesized fragments ...
Philipp Schoch, Tanja Gaich
wiley +1 more source
Modification of DNA by the benzo[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene. [PDF]
, 1978 T Kakefuda, Hiroaki Yamamoto
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Redirecting the Peptide Cleavage Causes Protease Inactivation
Angewandte Chemie International Edition, EarlyView.Cysteine proteases catalyze substrate cleavage by a two‐step acyl transfer mechanism. Newly designed peptidic inhibitors of human cathepsin B with N‐terminal carbamate warheads undergo a redirected cleavage and generate non‐canonical covalent complexes.
Christian Breuer +20 more
wiley +1 more source