Results 151 to 160 of about 101,558 (168)

Stereochemical Considerations on the Inhibition of Hepatic Epoxide Hydrolase by Some Pesticides and Their Epoxides

Toxicology Letters, 1986
The present studies identify the steric factors involved in the hydration of epoxide intermediates of some pesticides by hepatic epoxide hydrolase. Investigations were carried out regarding the formation of reactive epoxide intermediates and their different interactions with the hepatic epoxide hydrolase.
D. Cova, A. Arnoldi, R. Colombo, L. Rossini   +3 more
openaire   +3 more sources

Multiple forms of epoxide hydrolase

1984
Xenobiotic compounds are commonly rather nontoxic as such, but if they are lipophilic tend to accumulate in body tissues. The compounds must therefore be transformed to water-soluble metabolites in order to be excreted: in this process, reactive intermediates (such as epoxides, free radicals) can originate.
C. Timms, F. Oesch, Walter Wörner, L. Schladt   +3 more
openaire   +2 more sources

Leukotriene A4 hydrolase: An epoxide hydrolase with peptidase activity

Biochemical and Biophysical Research Communications, 1990
Purified leukotriene A4 hydrolase from human leukocytes is shown to exhibit peptidase activity towards the synthetic substrates alanine-4-nitroanilide and leucine-4-nitroanilide. The enzymatic activity is abolished after heat treatment (70 degrees C, 30 min).
Bert L. Vallee, Bert L. Vallee, Jesper Z. Haeggström, Bengt Samuelsson, Bengt Samuelsson, Anders Wetterholm, Anders Wetterholm   +6 more
openaire   +2 more sources

Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening

Journal of Chemical Information and Modeling, 2016
There is an increasing interest in the development of soluble epoxide hydrolase (sEH) inhibitors, which block the degradation of endogenous anti-inflammatory epoxyeicosatrienoic acids.
B. Waltenberger, U. Garscha, V. Temml, J. Liers, O. Werz, D. Schuster, H. Stuppner   +6 more
semanticscholar   +1 more source

The regulation of cytosolic epoxide hydrolase in mice

Biochemical and Biophysical Research Communications, 1985
The concentration of cytosolic epoxide hydrolase in untreated and clofibrate-treated mouse liver extracts was estimated by immunoblotting. Clofibrate treatment of mice was found to increase liver cytosolic epoxide hydrolase concentration by two fold, showing that the increase in cytosolic epoxide hydrolase in mouse liver after clofibrate treatment is ...
Sarjeet S. Gill, M.M. Pichare
openaire   +3 more sources

Multiparameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity, and Activity of an Epoxide Hydrolase

, 2016
The challenge of optimizing several parameters in the directed evolution of enzymes remains a central issue. In this study we address the thermostability, enantioselectivity, and activity of limonene epoxide hydrolase (LEH) as the catalyst in the ...
Guangyue Li, Hui Zhang, Zhoutong Sun, Xin-Qi Liu, M. Reetz   +4 more
semanticscholar   +1 more source

mesT, a unique epoxide hydrolase, is essential for optimal growth of Mycobacterium tuberculosis in the presence of styrene oxide.

Future Microbiology, 2017
AIM mesT of Mycobacterium tuberculosis, a hypothetical/putative epoxide hydrolase, is predicted to convert toxic epoxides to the more water-soluble and less toxic diols. Detailed characterization of the protein was carried out.
Manisha Chownk, Aashish Sharma, Kashmir Singh, J. Kaur   +3 more
semanticscholar   +1 more source

The role of epoxide hydrolases in health and disease

Archives of Toxicology, 2014
Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of xenobiotic epoxides, microsomal EH
Ahmed A. El-Sherbeni, Ayman O.S. El-Kadi
openaire   +3 more sources

KINETIC AND CHEMICAL MECHANISM OF EPOXIDE HYDROLASE*

Drug Metabolism Reviews, 1999
Epoxide hydrolases (EC 3.3.2.3) catalyze the trans-antiperiplanar addition of water to epoxides and arene oxides generated in the oxidation of unsaturated hydrocarbons [1][2][3].
openaire   +2 more sources

[46] Microsomal epoxide hydrolase

1981
Publisher Summary Microsomal epoxide hydrolase catalyzes the conversionof epoxides to glycols. The microsomal enzyme should not be confused with another epoxide hydrolase activity, found primarily in the cytosolic fraction, which differs greatly from membrane-bound enzyme in substrate specificity and immunological properties.
Thomas M. Guenthner, Philip Bentley, Franz Oesch   +2 more
openaire   +2 more sources