Results 131 to 140 of about 67,478 (222)

Quantum chemical studies of epoxide-transforming enzymes

, 2007
Density functional theory is employed to study the reaction mechanisms of different epoxide-transforming enzymes. Calculations are based on quantum chemical active site models, which are build from X-ray crystal structures.
Hopmann, Kathrin H.
core   +1 more source

Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors

Frontiers in Pharmacology, 2020
John D. Imig, Christophe Morisseau
doaj   +1 more source

TPPU, a soluble epoxide hydrolase inhibitor, mitigates Aβ-induced neurotoxicity via dual modulation of mitochondrial stabilization and JNK suppression. [PDF]

Biochem Biophys Rep
Song J, He A, Li S, Wu Q.
europepmc   +1 more source

Allosteric ensembles elucidate mechanisms of inhibition in the human soluble epoxide hydrolase. [PDF]

Commun Biol
Qiu Q, Gracia Carmona O, Abis G, Fraternali F, Conte MR.   +4 more
europepmc   +1 more source

Epoxide Hydrolase Family: Biological Functions, Disease Mechanisms, and Emerging Therapeutic Strategies. [PDF]

Biology (Basel)
Tan Y, Xu J, Huang Z, Wang X, Xing J, Li S, Yi J.   +6 more
europepmc   +1 more source

Soybean Epoxide Hydrolase [PDF]

Journal of Biological Chemistry, 2005
Elizabeth Blée, Stephan Summerer, Martine Flenet, Hélène Rogniaux, Alain Van Dorsselaer, Francis Schuber   +5 more
openaire   +1 more source

Fragment-Based Discovery of Fenamic Acids as Pan-Species Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. [PDF]

ACS Chem Biol
Zhu WF, Feugray G, Brunst S, Messaoudi H, Yang M, Martinez-Conde N, Krämer A, Weizel L, Ehrler JMH, Kramer JS, Kaiser A, Al-Tarrass M, Pereira T, Valet M, Brunel V, Schubert-Zsilavecz M, Knapp S, Lillich FF, Hernandez-Olmos V, Duflot T, Hiesinger K, Qian H, Proschak A, Bellien J, Proschak E.   +24 more
europepmc   +1 more source

Inhibition of soluble epoxide hydrolase ameliorates renal injury in IgA nephropathy by restoring epoxyeicosatrienoic acids. [PDF]

iScience
Yin HH, Fu X, Qiao Q, Yang E, Liu YN, Bai Y, Huang L, Chen YY, Huang ZY, Yu DC, Dai P, Pan QJ, Meng YW, Yin SY, Liu X, Nie S, Deng BQ, He Y, Liu JY.   +18 more
europepmc   +1 more source

Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing. [PDF]

FASEB J
Lu X, Morisseau C, Jain K, Chen Z, Estes AJ, Zeldin D, Gruzdev A, Ahmed A, Cook H, Hammock BD, Watsky MA.   +10 more
europepmc   +1 more source

Topliss-Guided Optimization of Acetanilide-Based Soluble Epoxide Hydrolase Inhibitors: Exploring the Pentafluorosulfanyl Group as a Potency-Enhancing Motif. [PDF]

ChemMedChem
López-Ruiz A, Pujol E, Ramos C, Rizzo V, Morisseau C, Val C, Ginex T, Vázquez J, Codony S, Turcu AL, Pérez B, Sáez E, Pineda-Lucena A, Hammock BD, Luque FJ, Loza MI, Brea J, Vázquez S.   +17 more
europepmc   +1 more source