Results 1 to 10 of about 507,315 (208)
Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese
International Journal of Hypertension, 2020 Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives.
Liang Ma +10 more
doaj +2 more sources
Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism
Frontiers in Molecular Neuroscience, 2020 The bifunctional enzyme soluble epoxide hydrolase (sEH) is found in all regions of the brain. It has two different catalytic activities, each assigned to one of its terminal domains: the C-terminal domain presents hydrolase activity, whereas the N ...
Michelle Flores Domingues +7 more
doaj +3 more sources
Scientific Reports, 2022 Myocardial infarction is still a life-threatening disease, even though its prognosis has been improved through the development of percutaneous coronary intervention and pharmacotherapy.
Takahiro Kitsuka +5 more
doaj +1 more source
The impact of the soluble epoxide hydrolase cascade on periodontal tissues
Frontiers in Dental Medicine, 2023 Periodontitis is a chronic inflammatory disease with complex pathogenesis. Uncontrolled inflammation is driven by the immune system in response to accumulation of oral biofilm that leads to alveolar bone loss, bleeding, increased periodontal probing ...
Henrique Ballassini Abdalla +2 more
doaj +1 more source
Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease
Cells, 2022 Cell responses to changes in their redox state are significantly mediated by reversible oxido-reductive post-translational modifications of proteins, potentially altering their activities or interactions.
Rebecca Charles, Philip Eaton
doaj +1 more source
Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation
Frontiers in Pharmacology, 2021 The soluble epoxide hydrolase (sEH) enzyme is a major regulator of bioactive lipids. The enzyme is highly expressed in liver and kidney and modulates levels of endogenous epoxy-fatty acids, which have pleiotropic biological effects including limiting ...
Karen M. Wagner +3 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2021 Background Alzheimer’s disease, cardiovascular disease, and other cardiometabolic disorders may share inflammatory origins. Lipid mediators, including oxylipins, endocannabinoids, bile acids, and steroids, regulate inflammation, energy metabolism, and ...
Kamil Borkowski +11 more
doaj +1 more source
Soluble epoxide hydrolase inhibition alleviates chemotherapy induced neuropathic pain
Frontiers in Pain Research, 2023 Chemotherapy induced peripheral neuropathy (CIPN) is a particularly pernicious form of neuropathy and the associated pain is the primary dose-limiting factor of life-prolonging chemotherapy treatment.
Ashley A. Takeshita +4 more
doaj +1 more source
Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies.
Aline Mello +9 more
doaj +1 more source
Natural Product Communications, 2016 SMTPs, a family of natural small molecules that effectively treat ischemic stroke, are subject to clinical development. SMTPs enhance plasminogen activation and inhibit soluble epoxide hydrolase (sEH), leading to promotion of endogenous thrombolysis and ...
Shinya Otake +4 more
doaj +1 more source