Results 1 to 10 of about 7,307 (207)

Inhibition of soluble epoxide hydrolase in endotoxin induced pig lung injury [PDF]

Frontiers in Pharmacology
Pharmacological inhibition of soluble epoxide hydrolase has been shown to attenuate lung injury development in rodents exposed to bacterial lipopolysaccharide. To investigate if these effects can be reproduced in larger animals, we tested soluble epoxide
Niklas Larsson, Cindy B. McReynolds, Sung Hee Hwang, Debin Wan, Jun Yang, Richard Lindberg, Stefan Lehtipalo, Jonas Claesson, Amanda Irgum Liljeström, Alicia Lind, Anders Brolin, Martin Isaksson Mettävainio, Bruce D. Hammock, Christophe Morisseau, Malin L. Nording, Malin L. Nording   +15 more
doaj   +4 more sources

Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase [PDF]

Journal of Lipid Research, 2011
Hepoxilins are lipid signaling molecules derived from arachidonic acid through the 12-lipoxygenase pathway. These trans-epoxy hydroxy eicosanoids play a role in a variety of physiological processes, including inflammation, neurotransmission, and ...
Annette Cronin, Martina Decker, Michael Arand   +2 more
doaj   +8 more sources

Inhibition of Soluble Epoxide Hydrolase for Renal Health [PDF]

Frontiers in Pharmacology, 2019
A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates.
Jun-Yan Liu, Jun-Yan Liu
doaj   +5 more sources

Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism

Frontiers in Molecular Neuroscience, 2020
The bifunctional enzyme soluble epoxide hydrolase (sEH) is found in all regions of the brain. It has two different catalytic activities, each assigned to one of its terminal domains: the C-terminal domain presents hydrolase activity, whereas the N ...
Michelle Flores Domingues, Michelle Flores Domingues, Natalia Callai-Silva, Natalia Callai-Silva, Angela Regina Piovesan, Celia Regina Carlini, Celia Regina Carlini, Celia Regina Carlini   +7 more
doaj   +3 more sources

Soluble Epoxide Hydrolase in Atherosclerosis [PDF]

Current Atherosclerosis Reports, 2010
Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols.
Wang, Yi-Xin Jim, Ulu, Arzu, Zhang, Le-Ning, Hammock, Bruce   +3 more
openaire   +7 more sources

Inhibition of soluble epoxide hydrolase by natural isothiocyanates. [PDF]

Biochem Biophys Res Commun
The long-term goal of our research is to develop safe and effective soluble epoxide hydrolase (sEH) inhibitors. The objective of this study is to evaluate the potency and selectivity of six natural isothiocyanates (ITCs) as sEH inhibitors.Molecular docking was used to model likely interactions between the ligands and receptors.
Elbarbry F, Espiritu MJ, Soo K, Yee B, Taylor J.   +4 more
europepmc   +3 more sources

Metabolic alteration in oxylipins and endocannabinoids point to an important role for soluble epoxide hydrolase and inflammation in Alzheimer’s disease—finding from Alzheimer’s Disease Neuroimaging Initiative [PDF]

Alzheimer’s Research & Therapy
Mounting evidence implicates inflammation as a key factor in Alzheimer’s disease (AD) development. We previously identified pro-inflammatory soluble epoxide hydrolase (sEH) metabolites to be elevated in plasma and CSF of AD participants and to be ...
Kamil Borkowski, Chunyuan Yin, Alida Kindt, Nuanyi Liang, Elizabeth de Lange, Colette Blach, John W. Newman, Rima Kaddurah-Daouk, Thomas Hankemeier, the Alzheimer’s Disease Neuroimaging Initiative   +9 more
doaj   +2 more sources

Disrupting Dimerization Translocates Soluble Epoxide Hydrolase to Peroxisomes.

PLoS ONE, 2016
The epoxyeicosatrienoic acid (EET) neutralizing enzyme soluble epoxide hydrolase (sEH) is a neuronal enzyme, which has been localized in both the cytosol and peroxisomes.
Jonathan W Nelson, Anjali J Das, Anthony P Barnes, Nabil J Alkayed   +3 more
doaj   +3 more sources

Mechanism of Soluble Epoxide Hydrolase [PDF]

Journal of Biological Chemistry, 1995
Soluble epoxide hydrolase (sEH) is a ubiquitous mammalian enzyme for which liver and kidney are reported to have the highest activity. We have shown that the soluble epoxide hydrolase (sEH) activity present in rat neutrophils and macrophages is kinetically, immunologically, and physically indistinguishable from rat liver cytosolic sEH. Cytosol from rat
Babak Borhan, A. Daniel Jones, Franck Pinot, David F. Grant, Mark J. Kurth, Bruce D. Hammock   +5 more
  +7 more sources

A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction

Scientific Reports, 2022
Myocardial infarction is still a life-threatening disease, even though its prognosis has been improved through the development of percutaneous coronary intervention and pharmacotherapy.
Takahiro Kitsuka, Aya Shiraki, Jun-ichi Oyama, Hironori Nakagami, Atsushi Tanaka, Koichi Node   +5 more
doaj   +1 more source