Results 41 to 50 of about 7,307 (207)

Soluble Epoxide Hydrolase Inhibition Prevents Experimental Type 4 Cardiorenal Syndrome

Frontiers in Molecular Biosciences, 2021
Objectives: Cardiovascular diseases (CVD) remain the leading cause of morbimortality in patients with chronic kidney disease (CKD). The aim of this study was to assess the cardiovascular impact of the pharmacological inhibition of soluble epoxide ...
Mouad Hamzaoui, Mouad Hamzaoui, Clothilde Roche, David Coquerel, Thomas Duflot, Thomas Duflot, Valery Brunel, Paul Mulder, Vincent Richard, Jérémy Bellien, Jérémy Bellien, Dominique Guerrot, Dominique Guerrot   +12 more
doaj   +1 more source

Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats [PDF]

, 2011
The signs of metabolic syndrome following chronic excessive macronutrient intake include body weight gain, excess visceral adipose deposition, hyperglycaemia, glucose and insulin intolerances, hypertension, dyslipidaemia, endothelial damage ...
Alam, Md. Ashraful, Md. Ashraful Alam, Lindsay Brown, Hwang, Sung Hee, Sung Hee Hwang, Abishek Iyer, Iyer, Abishek, Kauter, Kathleen, Morisseau, Christophe, Bruce D. Hammock, Kathleen Kauter, Christophe Morisseau, Brown, Lindsay, Hammock, Bruce D.   +13 more
core   +1 more source

Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates [PDF]

, 1997
Mammalian soluble and microsomal epoxide hydrolases have been proposed to belong to the family of alpha/beta-hydrolase-fold enzymes. These enzymes hydrolyse their substrates by a catalytic triad, with the first step of the enzymatic reaction being the ...
Willy Hinz, Oesch, F, Seidel, A, Blée, E, Albrecht Seidel, Hinz, W, Frank Müller, Lars Winkler, Arand, Michael; https://orcid.org/, Hänel, K, Beetham, J K, Heinz Frank, Franz Oesch, Hammock, B D, Karen Hänel, Bruce D. Hammock, Elizabeth Blée, Jeffrey K. Beetham, Müller, F, Michael Arand, Frank, H, Winkler, L   +21 more
core   +1 more source

Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase [PDF]

, 2022
S.1244-1249Multitarget ligands are interesting candidates for drug discovery and development due to improved safety and efficacy. However, rational design and optimization of multitarget ligands is tedious because affinity optimization for two or more ...
Hefke, L., Kramer, J.S., Zhu, W.F., Proschak, E., Hiesinger, K.   +4 more
core   +1 more source

Soluble Epoxide Hydrolase [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Objective— Sex differences in cerebral ischemic injury are, in part, arrtibutable to the differences in cerebrovascular perfusion. We determined whether the brain microvascular endothelial cells (ECs) isolated from the female brain are more resistant to ischemic injury compared with male ECs, and whether the difference is ...
Nandita C, Gupta, Catherine M, Davis, Jonathan W, Nelson, Jennifer M, Young, Nabil J, Alkayed   +4 more
openaire   +2 more sources

Soluble epoxide hydrolase inhibitor promotes the healing of oral ulcers [PDF]

, 2023
Objective: Oral ulcers are a lesion in the oral mucosa that impacts chewing or drinking. Epoxyeicosatrienoic Acids (EETs) have enhanced angiogenic, regenerative, anti-inflammatory, and analgesic effects.
Gao, Lu, Jili Chen, Yue Lou, Li, Juanjuan, Lou, Yue, Juanjuan Li, Lu Gao, Zihan Wen, Wang, Fu, Fu Wang, Xiaojie Li, Wen, Zihan, Chen, Jili, Li, Xiaojie   +13 more
core   +1 more source

Protective Effects of the Soluble Epoxide Hydrolase Inhibitor 1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea in a Rat Model of Permanent Middle Cerebral Artery Occlusion

Frontiers in Pharmacology, 2020
Acute ischemic stroke is a serious disease that endangers human health. In our efforts to develop an effective therapy, we previously showed that the potent, highly selective inhibitor of soluble epoxide hydrolase called 1-trifuoromethoxyphenyl-3-(1 ...
Linlei Zhang, Linlei Zhang, Shasha Xu, Xiaoxiao Wu, Farah Mohamed Muse, Jiaou Chen, Yungang Cao, Jueyue Yan, Zicheng Cheng, Xingyang Yi, Zhao Han   +10 more
doaj   +1 more source

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

PLoS ONE, 2017
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes, Artiom Gruzdev, Matthew L Edin, Joan P Graves, J Alyce Bradbury, Gordon P Flake, Fred B Lih, Laura M DeGraff, Darryl C Zeldin   +8 more
doaj   +1 more source

Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain [PDF]

, 2020
The role of lipids in pain signaling is well established and built on decades of knowledge about the pain and inflammation produced by prostaglandin and leukotriene metabolites of cyclooxygenase and lipoxygenase metabolism, respectively.
Hammock, Bruce D, Gomes, Aldrin, McReynolds, Cindy B, Wagner, Karen M   +3 more
core   +1 more source

Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice. [PDF]

PLoS ONE, 2016
AIM:20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis.
Ye Zhu, Maximilian Blum, Uwe Hoff, Tim Wesser, Mandy Fechner, Christina Westphal, Dennis Gürgen, Rusan Ali Catar, Aurelie Philippe, Kaiyin Wu, Gordana Bubalo, Michael Rothe, Steven M Weldon, Duska Dragun, Wolf-Hagen Schunck   +14 more
doaj   +1 more source