Results 41 to 50 of about 507,315 (208)

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

PLoS ONE, 2017
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes, Artiom Gruzdev, Matthew L Edin, Joan P Graves, J Alyce Bradbury, Gordon P Flake, Fred B Lih, Laura M DeGraff, Darryl C Zeldin   +8 more
doaj   +1 more source

Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice. [PDF]

PLoS ONE, 2016
AIM:20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis.
Ye Zhu, Maximilian Blum, Uwe Hoff, Tim Wesser, Mandy Fechner, Christina Westphal, Dennis Gürgen, Rusan Ali Catar, Aurelie Philippe, Kaiyin Wu, Gordana Bubalo, Michael Rothe, Steven M Weldon, Duska Dragun, Wolf-Hagen Schunck   +14 more
doaj   +1 more source

Pharmacological inhibition of soluble epoxide hydrolase protects cognitive impairment in a Niemann-Pick mice model [PDF]

, 2020
Niemann-Pick type C (NPC) disease is a childhood autosomal recessive inherited rare neurodegenerative disease characterized by accumulation of cholesterol and glycosphingolipids and where the autophagy-lysosome system and inflammatory processes are ...
Cozar, Mónica, Vilageliu i Arqués, Lluïsa, Grinberg Vaisman, Daniel Raúl, Griñán Ferré, Christian, Pallàs i Llibería, Mercè, 1964-, Codony Gisbert, Sandra, Companys Alemany, Júlia, Vázquez Cruz, Santiago   +7 more
core   +3 more sources

Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death

Molecules
Nineteen potential mimics of 8,9-epoxyeicosatrienoic acid (8,9-EET), a natural bioactive oxylipin, were synthesized and evaluated for their ability to protect renal mesangial cells against sorafenib-induced cell death in a water-soluble tetrazolium (WST ...
Marcus de Bourg, Abhishek Mishra, Rawand S. Mohammad, Christophe Morisseau, Bruce D. Hammock, John D. Imig, Anders Vik   +6 more
doaj   +1 more source

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

, 2009
A class of potent non-urea inhibitors of soluble epoxide hydrolase was discovered via high throughput screening and SARs-guided modification. Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A
Yan, Fang, Xie, Yuli, Schürer, Stephan, Li, Xiangpo, Feng, Yan, Vidović, Dušica, Smith, Deborah H, Landry, Donald W, Gong, Gangli, Morisseau, Christophe, Deng, Shi-Xian, Hammock, Bruce D, Liu, Yidong, Rinderspacher, Alison, Branden, Lars, Zhu, Zhengxiang, Chung, Caty   +16 more
core   +1 more source

Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats [PDF]

, 2011
The signs of metabolic syndrome following chronic excessive macronutrient intake include body weight gain, excess visceral adipose deposition, hyperglycaemia, glucose and insulin intolerances, hypertension, dyslipidaemia, endothelial damage ...
Alam, Md. Ashraful, Md. Ashraful Alam, Lindsay Brown, Hwang, Sung Hee, Sung Hee Hwang, Abishek Iyer, Iyer, Abishek, Kauter, Kathleen, Morisseau, Christophe, Bruce D. Hammock, Kathleen Kauter, Christophe Morisseau, Brown, Lindsay, Hammock, Bruce D.   +13 more
core   +1 more source

Polycyclic compounds as soluble epoxide hydrolase inhibitors

Invention Disclosure
In this invention, a novel family of benzohomoadamantane-based soluble epoxide hydrolase inhibitors is disclosed. The benzohomoadamantane scaffold is a polycyclic, readily accessible, system that features a homoadamantane unit fused with an aromatic ring.
S. Codony, E. Valverde, C. Galdeano, A.L. Turcu, R. Leiva, S. Vázquez   +5 more
doaj   +1 more source

Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase

Journal of Lipid Research, 2012
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has a C-terminus epoxide hydrolase domain and an N-terminus phosphatase domain. The endogenous substrates of epoxide hydrolase are known to be epoxyeicosatrienoic acids, but the endogenous ...
Ami Oguro, Susumu Imaoka
doaj   +1 more source

The role of soluble epoxide hydrolase and its inhibitors in depression

Brain, Behavior, & Immunity - Health, 2021
Evidence suggests that around 30 ​% of patients with depression do not respond to antidepressant treatment, with most of them having sub-chronic levels of inflammation.
Alessandra Borsini
doaj   +1 more source

TPPU inhibits inflammation-induced excessive autophagy to restore the osteogenic differentiation potential of stem cells and improves alveolar ridge preservation

Scientific Reports, 2023
Inflammation-induced autophagy is a double-edged sword. Dysfunction of autophagy impairs the differentiation capacity of mesenchymal stem cells and enhances inflammation-induced bone loss.
Haixia Dang, Weixian Chen, Lan Chen, Xinru Huo, Fu Wang   +4 more
doaj   +1 more source