Results 21 to 30 of about 507,315 (208)

Metabolic alteration in oxylipins and endocannabinoids point to an important role for soluble epoxide hydrolase and inflammation in Alzheimer’s disease—finding from Alzheimer’s Disease Neuroimaging Initiative [PDF]

Alzheimer’s Research & Therapy
Mounting evidence implicates inflammation as a key factor in Alzheimer’s disease (AD) development. We previously identified pro-inflammatory soluble epoxide hydrolase (sEH) metabolites to be elevated in plasma and CSF of AD participants and to be ...
Kamil Borkowski, Chunyuan Yin, Alida Kindt, Nuanyi Liang, Elizabeth de Lange, Colette Blach, John W. Newman, Rima Kaddurah-Daouk, Thomas Hankemeier, the Alzheimer’s Disease Neuroimaging Initiative   +9 more
doaj   +2 more sources

Soluble Epoxide Hydrolase in Atherosclerosis [PDF]

Current Atherosclerosis Reports, 2010
Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols.
Wang, Yi-Xin Jim, Ulu, Arzu, Zhang, Le-Ning, Hammock, Bruce   +3 more
openaire   +4 more sources

Mechanism of Soluble Epoxide Hydrolase [PDF]

Journal of Biological Chemistry, 1995
Soluble epoxide hydrolase (sEH) is a ubiquitous mammalian enzyme for which liver and kidney are reported to have the highest activity. We have shown that the soluble epoxide hydrolase (sEH) activity present in rat neutrophils and macrophages is kinetically, immunologically, and physically indistinguishable from rat liver cytosolic sEH. Cytosol from rat
Babak Borhan, A. Daniel Jones, Franck Pinot, David F. Grant, Mark J. Kurth, Bruce D. Hammock   +5 more
  +7 more sources

Soluble Epoxide Hydrolase and Diabetes Complications

International Journal of Molecular Sciences, 2022
Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke.
Natasha Z. Anita, Walter Swardfager
openaire   +2 more sources

Soluble Epoxide Hydrolase Dimerization Is Required for Hydrolase Activity [PDF]

Journal of Biological Chemistry, 2013
Soluble epoxide hydrolase (sEH) plays a key role in the metabolic conversion of the protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoic acid. Accordingly, inhibition of sEH hydrolase activity has been shown to be beneficial in multiple models of cardiovascular diseases, thus identifying sEH as a valuable therapeutic ...
Jonathan W, Nelson, Rishi M, Subrahmanyan, Sol A, Summers, Xiangshu, Xiao, Nabil J, Alkayed   +4 more
openaire   +2 more sources

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease [PDF]

, 2010
Epoxyeicotrienoic acids (EETs) are cytochrome P450-dependent anti-hypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered reno-protective.
Geisslinger, Gerd, Gerd Geisslinger, Tsai, Cindy, Ralf P. Brandes, Brandes, Ralf, Schäfer, Liliana, Amann Kerstin, Liliana Schaefer, Kerstin Amann, Felix Jansen, Jung, Oliver, Ralf P Brandes, Mieth Anja, Hwang Sung H., Schaefer Liliana, Anja Mieth, Hwang, Sung H., Barbosa-Sicard Eduardo, Sung H. Hwang, Bruce D. Hammock, Hammock Bruce D., Christophe Morisseau, Cindy Tsai, Rainer U. Pliquett, Oliver Jung, Brandes Ralf P., Pliquett Rainer U., Mieth, Anja, Babelova, Andrea, Barbosa Sicard, Eduardo, Geisslinger Gerd, Jansen, Felix, Andrea Babelova, Sung H Hwang, Morisseau, Christophe, Pliquett, Rainer U., Eduardo Barbosa-Sicard, Jung Oliver, Rainer U Pliquett, Bruce D Hammock, Jansen Felix, Tsai Cindy, Morisseau Christophe, Amann, Kerstin, Hammock, Bruce D., Babelova Andrea   +45 more
core   +2 more sources

Unilateral ureteral obstruction (UUO) increases soluble epoxide hydrolase (sEH) expression and activity.

, 2022
 Supplementary Figure 2. Unilateral ureteral obstruction (UUO) increases soluble epoxide hydrolase (sEH) expression and activity.  
Babu Padanilam (12174263)
core   +1 more source

Inhibition of Soluble Epoxide Hydrolase Reduces Paraquat Neurotoxicity in Rodents [PDF]

, 2022
Paraquat is one of the most common and acutely toxic herbicides used in developing nations, with epidemiological studies linking chronic paraquat exposure to Parkinson’s disease.
Atone, Jogen
core   +1 more source

Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology [PDF]

Physiological Reviews, 2012
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis.
openaire   +2 more sources

Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase and ethanolamides metabolism with Alzheimer’s disease [PDF]

, 2021
: Alzheimer’s disease shares inflammatory origin with cardiometabolic disorders. Lipid mediators, including oxylipins, endocannabinoids, bile acids and steroids are potent regulators of inflammation, energy metabolism and cell proliferation with well ...
Seyfried, Nicholas T, Lah, James J, Hales, Chadwick M, Dammer, Eric B, Blach, Colette, Consortium, Alzheimer’s Disease Metabolomics, Newman, John W, Kaddurah-Daouk, Rima, Pedersen, Theresa L, Levey, Allan I, Borkowski, Kamil, Louie, Gregory, James J. Lah, Kamil Borkowski, Theresa L. Pedersen, John W. Newman, Rima Kaddurah-Daouk, Colette Blach, Chadwick M. Hales, Gregory Louie, Allan I. Levey, null null, Eric B. Dammer, Nicholas T. Seyfried   +23 more
core   +1 more source