The impact of the soluble epoxide hydrolase cascade on periodontal tissues
Frontiers in Dental Medicine, 2023 Periodontitis is a chronic inflammatory disease with complex pathogenesis. Uncontrolled inflammation is driven by the immune system in response to accumulation of oral biofilm that leads to alveolar bone loss, bleeding, increased periodontal probing ...
Henrique Ballassini Abdalla +2 more
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Identification of Food-Derived Peptide Inhibitors of Soluble Epoxide Hydrolase [PDF]
, 2023 Over the course of more than ten years, there has been a significant increase in the approach employed to inhibit the function of soluble epoxide hydrolase (sEH).
Obeme-Nmom, Joy
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Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease
Cells, 2022 Cell responses to changes in their redox state are significantly mediated by reversible oxido-reductive post-translational modifications of proteins, potentially altering their activities or interactions.
Rebecca Charles, Philip Eaton
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Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation
Frontiers in Pharmacology, 2021 The soluble epoxide hydrolase (sEH) enzyme is a major regulator of bioactive lipids. The enzyme is highly expressed in liver and kidney and modulates levels of endogenous epoxy-fatty acids, which have pleiotropic biological effects including limiting ...
Karen M. Wagner +3 more
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Unilateral ureteral obstruction (UUO) increases soluble epoxide hydrolase (sEH) expression and activity. [PDF]
, 2022 Supplementary Figure 2. Unilateral ureteral obstruction (UUO) increases soluble epoxide hydrolase (sEH) expression and activity.
Babu Padanilam (12174263)
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Soluble Epoxide Hydrolase Dimerization Is Required for Hydrolase Activity [PDF]
Journal of Biological Chemistry, 2013 Soluble epoxide hydrolase (sEH) plays a key role in the metabolic conversion of the protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoic acid. Accordingly, inhibition of sEH hydrolase activity has been shown to be beneficial in multiple models of cardiovascular diseases, thus identifying sEH as a valuable therapeutic ...
Jonathan W, Nelson +4 more
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Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase and ethanolamides metabolism with Alzheimer’s disease [PDF]
, 2021 : Alzheimer’s disease shares inflammatory origin with cardiometabolic disorders. Lipid mediators, including oxylipins, endocannabinoids, bile acids and steroids are potent regulators of inflammation, energy metabolism and cell proliferation with well ...
Seyfried, Nicholas T +11 more
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Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease [PDF]
, 2010 Epoxyeicotrienoic acids (EETs) are cytochrome P450-dependent anti-hypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered reno-protective.
Geisslinger, Gerd +45 more
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Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology [PDF]
Physiological Reviews, 2012 Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis.
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Soluble epoxide hydrolase inhibition alleviates chemotherapy induced neuropathic pain
Frontiers in Pain Research, 2023 Chemotherapy induced peripheral neuropathy (CIPN) is a particularly pernicious form of neuropathy and the associated pain is the primary dose-limiting factor of life-prolonging chemotherapy treatment.
Ashley A. Takeshita +4 more
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