Results 11 to 20 of about 507,315 (208)

Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase [PDF]

Journal of Lipid Research, 2011
Hepoxilins are lipid signaling molecules derived from arachidonic acid through the 12-lipoxygenase pathway. These trans-epoxy hydroxy eicosanoids play a role in a variety of physiological processes, including inflammation, neurotransmission, and ...
Annette Cronin, Martina Decker, Michael Arand   +2 more
doaj   +7 more sources

Inhibition of soluble epoxide hydrolase in endotoxin induced pig lung injury [PDF]

Frontiers in Pharmacology
Pharmacological inhibition of soluble epoxide hydrolase has been shown to attenuate lung injury development in rodents exposed to bacterial lipopolysaccharide. To investigate if these effects can be reproduced in larger animals, we tested soluble epoxide
Niklas Larsson, Cindy B. McReynolds, Sung Hee Hwang, Debin Wan, Jun Yang, Richard Lindberg, Stefan Lehtipalo, Jonas Claesson, Amanda Irgum Liljeström, Alicia Lind, Anders Brolin, Martin Isaksson Mettävainio, Bruce D. Hammock, Christophe Morisseau, Malin L. Nording, Malin L. Nording   +15 more
doaj   +3 more sources

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]

Molecular Pain, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Brandes Ralf P, Fleming Ingrid, Angioni Carlo, Fischer Michael J, Altenrath Kai, Coste Ovidiu, Sisignano Marco, Brenneis Christian, Reeh Peter W, Woolf Clifford J, Geisslinger Gerd, Scholich Klaus   +11 more
doaj   +4 more sources

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling [PDF]

Cell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen, Liangliang Liu, Xumeng Wang, Juanjuan Li, Jingyi Zhang, Xiaoli Shi, Qing Sun, Xu Chang, Jing Zhang, Jie Zhao, Fu Wang   +10 more
wiley   +2 more sources

Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides [PDF]

Bioorganic & Medicinal Chemistry Letters, 2013
The soluble epoxide hydrolase (sEH) is a key enzyme in the metabolism of epoxy-fatty acids, signaling molecules involved in numerous biologies. Toward finding novel inhibitors of sEH, a library of known drugs was tested for inhibition of sEH. We found that fulvestrant, an anticancer agent, is a potent (KI=26 nM) competitive inhibitor of sEH.
Christophe, Morisseau, Svitlana, Pakhomova, Sung Hee, Hwang, Marcia E, Newcomer, Bruce D, Hammock   +4 more
openaire   +4 more sources

Adamantyl thioureas as soluble epoxide hydrolase inhibitors [PDF]

Bioorganic & Medicinal Chemistry Letters, 2018
A series of inhibitors of the soluble epoxide hydrolase (sEH) containing one or two thiourea groups has been developed. Inhibition potency of the described compounds ranges from 50 μM to 7.2 nM. 1,7-(Heptamethylene)bis[(adamant-1-yl)thiourea] (6f) was found to be the most potent sEH inhibitor, among the thioureas tested.
Vladimir Burmistrov, Christophe Morisseau, Dmitry Pitushkin, Dmitry Karlov, Robert R. Fayzullin, Gennady M. Butov, Bruce D. Hammock   +6 more
openaire   +6 more sources

Inhibition of Soluble Epoxide Hydrolase for Renal Health [PDF]

Frontiers in Pharmacology, 2019
A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates.
Jun-Yan Liu, Jun-Yan Liu
doaj   +3 more sources

Inhibition of the Soluble Epoxide Hydrolase by Tyrosine Nitration [PDF]

Journal of Biological Chemistry, 2009
Inhibition of the soluble epoxide hydrolase (sEH) has beneficial effects on vascular inflammation and hypertension indicating that the enzyme may be a promising target for drug development. As the enzymatic core of the hydrolase domain of the human sEH contains two tyrosine residues (Tyr(383) and Tyr(466)) that are theoretically crucial for enzymatic ...
Barbosa Sicard, Eduardo, Frömel, Timo, Keserü, Benjamin, Brandes, Ralf, Morisseau, Christophe, Hammock, Bruce D., Braun, Thomas, Krüger, Marcus, Fleming, Ingrid   +8 more
openaire   +4 more sources

Inhibition of soluble epoxide hydrolase by natural isothiocyanates. [PDF]

Biochem Biophys Res Commun
The long-term goal of our research is to develop safe and effective soluble epoxide hydrolase (sEH) inhibitors. The objective of this study is to evaluate the potency and selectivity of six natural isothiocyanates (ITCs) as sEH inhibitors.Molecular docking was used to model likely interactions between the ligands and receptors.
Elbarbry F, Espiritu MJ, Soo K, Yee B, Taylor J.   +4 more
europepmc   +3 more sources

Soluble epoxide hydrolase in the human placenta throughout gestation

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: To investigate the spatial and temporal changes of soluble epoxide hydrolase (sEH) in the human placenta throughout gestation and to study the effects of hypoxia-reoxygenation (HR) on the expression of sEH in villous explants in vitro ...
Tai-Ho Hung, Szu-Fu Chen, T'sang-T'ang Hsieh   +2 more
doaj   +2 more sources