Results 11 to 20 of about 7,307 (207)

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]

Molecular Pain, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Brandes Ralf P, Fleming Ingrid, Angioni Carlo, Fischer Michael J, Altenrath Kai, Coste Ovidiu, Sisignano Marco, Brenneis Christian, Reeh Peter W, Woolf Clifford J, Geisslinger Gerd, Scholich Klaus   +11 more
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Inhibition of the Soluble Epoxide Hydrolase by Tyrosine Nitration [PDF]

Journal of Biological Chemistry, 2009
Inhibition of the soluble epoxide hydrolase (sEH) has beneficial effects on vascular inflammation and hypertension indicating that the enzyme may be a promising target for drug development. As the enzymatic core of the hydrolase domain of the human sEH contains two tyrosine residues (Tyr(383) and Tyr(466)) that are theoretically crucial for enzymatic ...
Barbosa Sicard, Eduardo, Frömel, Timo, Keserü, Benjamin, Brandes, Ralf, Morisseau, Christophe, Hammock, Bruce D., Braun, Thomas, Krüger, Marcus, Fleming, Ingrid   +8 more
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Soluble Epoxide Hydrolase and Diabetes Complications [PDF]

International Journal of Molecular Sciences, 2022
Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke.
Natasha Z. Anita, Walter Swardfager
openaire   +4 more sources

Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese [PDF]

International Journal of Hypertension, 2020
Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives.
Liang Ma, Hailing Zhao, Meijie Yu, Yumin Wen, Tingting Zhao, Meihua Yan, Qian Liu, Yongwei Jiang, Yongtong Cao, Ping Li, Wenquan Niu   +10 more
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Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy [PDF]

Nature, 2017
Diabetic retinopathy is an important cause of blindness in adults, and is characterized by progressive loss of vascular cells and slow dissolution of inter-vascular junctions, which result in vascular leakage and retinal oedema. Later stages of the disease are characterized by inflammatory cell infiltration, tissue destruction and neovascularization ...
Hu, Jiong, Dziumbla, Sarah, Lin, Jihong, Bibli, Sofia-Iris, Zukunft, Sven, de Mos, Julian, Awwad, Khader, Frömel, Timo, Jungmann, Andreas, Devraj, Kavi, Cheng, Zhixing, Wang, Liya, Fauser, Sascha, Eberhart, Charles G, Sodhi, Akrit, Hammock, Bruce D, Liebner, Stefan, Müller, Oliver J, Glaubitz, Clemens, Hammes, Hans-Peter, Popp, Rüdiger, Fleming, Ingrid   +21 more
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Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease [PDF]

Alzheimer’s Research & Therapy, 2021
Background Alzheimer’s disease, cardiovascular disease, and other cardiometabolic disorders may share inflammatory origins. Lipid mediators, including oxylipins, endocannabinoids, bile acids, and steroids, regulate inflammation, energy metabolism, and ...
Kamil Borkowski, Theresa L. Pedersen, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Chadwick M. Hales, Eric B. Dammer, Colette Blach, Gregory Louie, Rima Kaddurah-Daouk, John W. Newman, Alzheimer’s Disease Metabolomics Consortium   +11 more
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Adamantyl thioureas as soluble epoxide hydrolase inhibitors [PDF]

Bioorganic & Medicinal Chemistry Letters, 2018
A series of inhibitors of the soluble epoxide hydrolase (sEH) containing one or two thiourea groups has been developed. Inhibition potency of the described compounds ranges from 50 μM to 7.2 nM. 1,7-(Heptamethylene)bis[(adamant-1-yl)thiourea] (6f) was found to be the most potent sEH inhibitor, among the thioureas tested.
Vladimir Burmistrov, Christophe Morisseau, Dmitry Pitushkin, Dmitry Karlov, Robert R. Fayzullin, Gennady M. Butov, Bruce D. Hammock   +6 more
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Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides [PDF]

Bioorganic & Medicinal Chemistry Letters, 2013
The soluble epoxide hydrolase (sEH) is a key enzyme in the metabolism of epoxy-fatty acids, signaling molecules involved in numerous biologies. Toward finding novel inhibitors of sEH, a library of known drugs was tested for inhibition of sEH. We found that fulvestrant, an anticancer agent, is a potent (KI=26 nM) competitive inhibitor of sEH.
Christophe, Morisseau, Svitlana, Pakhomova, Sung Hee, Hwang, Marcia E, Newcomer, Bruce D, Hammock   +4 more
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Soluble epoxide hydrolase in the human placenta throughout gestation [PDF]

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: To investigate the spatial and temporal changes of soluble epoxide hydrolase (sEH) in the human placenta throughout gestation and to study the effects of hypoxia-reoxygenation (HR) on the expression of sEH in villous explants in vitro ...
Tai-Ho Hung, Szu-Fu Chen, T'sang-T'ang Hsieh   +2 more
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2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity [PDF]

Pharmaceuticals, 2021
The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids.
Juan Martín-López, Sandra Codony, Clara Bartra, Christophe Morisseau, María Isabel Loza, Coral Sanfeliu, Bruce D. Hammock, José Brea, Santiago Vázquez   +8 more
doaj   +3 more sources