Genetic variants in epoxyeicosatrienoic acid processing and degradation pathways are associated with gestational diabetes mellitus [PDF]
Nutrition Journal, 2023 Aim To explore the genetic effects of CYP2C8, CYP2C9, CYP2J2, and EPHX2, the key genes involved in epoxyeicosatrienoic acid processing and degradation pathways in gestational diabetes mellitus (GDM) and metabolic traits in Chinese pregnant women. Methods
Siyu Lai +11 more
doaj +2 more sources
Fatty acid binding proteins are novel modulators of synaptic epoxyeicosatrienoic acid signaling in the brain [PDF]
Scientific Reports, 2023 Fatty acid binding proteins (FABPs) govern intracellular lipid transport to cytosolic organelles and nuclear receptors. More recently, FABP5 has emerged as a key regulator of synaptic endocannabinoid signaling, suggesting that FABPs may broadly regulate ...
Sherrye T. Glaser +10 more
doaj +2 more sources
Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death [PDF]
MoleculesNineteen potential mimics of 8,9-epoxyeicosatrienoic acid (8,9-EET), a natural bioactive oxylipin, were synthesized and evaluated for their ability to protect renal mesangial cells against sorafenib-induced cell death in a water-soluble tetrazolium (WST ...
Marcus de Bourg +6 more
doaj +2 more sources
Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition [PDF]
Frontiers in Pharmacology, 2017 Renal fibrosis, which is a critical pathophysiological event in chronic kidney diseases, is associated with renal epithelial-to-mesenchymal transition (EMT).
Melissa Skibba +6 more
doaj +2 more sources
Epoxyeicosatrienoic Acid Analog EET-A Blunts Development of Lupus Nephritis in Mice [PDF]
Frontiers in Pharmacology, 2019 Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disorder that causes life threatening renal disease and current therapies are limited with serious side-effects.
Md. Abdul Hye Khan +4 more
doaj +2 more sources
11,12 and 14,15 epoxyeicosatrienoic acid rescue deteriorated wound healing in ischemia. [PDF]
PLoS ONE, 2019 IntroductionEpoxyeicosatrienoic acids (EETs) are able to enhance angiogenesis and regulate inflammation that is especially important in wound healing under ischemic conditions.
Katharina Sommer +6 more
doaj +2 more sources
Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats [PDF]
Frontiers in Pharmacology, 2019 Epoxyeicosatrienoic acids (EETs) and their analogs have been identified as potent antihypertensive compounds with cardio- and renoprotective actions. Here, we examined the effect of EET-A, an orally active EET analog, and c-AUCB, an inhibitor of the EETs
Jaroslav Hrdlička +17 more
doaj +2 more sources
Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2 [PDF]
Journal of Lipid Research, 2019 Epoxyeicosatrienoic acids (EETs) are formed from the metabolism of arachidonic acid by cytochrome P450s. EETs promote angiogenesis linked to tumor growth in various cancer models that is attenuated in vivo by cyclooxygenase 2 (COX-2) inhibitors.
Amy A. Rand +7 more
doaj +2 more sources
Stem cell-secreted 14,15- epoxyeicosatrienoic acid rescues cholesterol homeostasis and autophagic flux in Niemann–Pick-type C disease [PDF]
Experimental and Molecular Medicine, 2018 Inherited metabolic disease: Restoring motor function by reducing cholesterol An acid secreted by stem cells can reduce the excess cholesterol caused by a genetic metabolic disorder.
Insung Kang +10 more
doaj +2 more sources
Epoxyeicosatrienoic acid activation moderates endothelial mesenchymal transition to reduce obstructive nephropathy [PDF]
Kidney Research and Clinical Practice, 2017 Babu J. Padanilam
doaj +2 more sources