Genetic variants in epoxyeicosatrienoic acid processing and degradation pathways are associated with gestational diabetes mellitus [PDF]
Nutrition Journal, 2023 Aim To explore the genetic effects of CYP2C8, CYP2C9, CYP2J2, and EPHX2, the key genes involved in epoxyeicosatrienoic acid processing and degradation pathways in gestational diabetes mellitus (GDM) and metabolic traits in Chinese pregnant women. Methods
Siyu Lai +11 more
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Fatty acid binding proteins are novel modulators of synaptic epoxyeicosatrienoic acid signaling in the brain [PDF]
Scientific Reports, 2023 Fatty acid binding proteins (FABPs) govern intracellular lipid transport to cytosolic organelles and nuclear receptors. More recently, FABP5 has emerged as a key regulator of synaptic endocannabinoid signaling, suggesting that FABPs may broadly regulate ...
Sherrye T. Glaser +10 more
doaj +2 more sources
The Hunt for the Putative Epoxyeicosatrienoic Acid Receptor. [PDF]
ACS Chem BiolEpoxyeicosatrienoic acids, or EETs, are signaling molecules formed by the metabolism of arachidonic acid by cytochrome P450 enzymes. They are well-known for their anti-inflammatory effects, their ability to lower blood pressure, and benefits to cardiovascular outcomes.
Arnold WR, Jain S, Sinha V, Das A.
europepmc +3 more sources
Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats [PDF]
Frontiers in Pharmacology, 2022 Numerous studies indicate a significant role for cytochrome P-450-dependent arachidonic acid metabolites in blood pressure regulation, vascular tone, and control of renal function. Epoxyeicosatrienoic acids (EETs) exhibit a spectrum of beneficial effects,
Iwona Baranowska +10 more
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Orally Active Epoxyeicosatrienoic Acid Analogs. [PDF]
J Cardiovasc Pharmacol, 2017 Abstract: Biologically active epoxyeicosatrienoic acid (EET) regioisomers are synthesized from arachidonic acid by cytochrome P450 epoxygenases of endothelial, myocardial, and renal tubular cells. EETs relax vascular smooth muscle and decrease inflammatory cell adhesion and cytokine release.
Campbell WB +3 more
europepmc +4 more sources
Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death [PDF]
MoleculesNineteen potential mimics of 8,9-epoxyeicosatrienoic acid (8,9-EET), a natural bioactive oxylipin, were synthesized and evaluated for their ability to protect renal mesangial cells against sorafenib-induced cell death in a water-soluble tetrazolium (WST ...
Marcus de Bourg +6 more
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Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition [PDF]
Frontiers in Pharmacology, 2017 Renal fibrosis, which is a critical pathophysiological event in chronic kidney diseases, is associated with renal epithelial-to-mesenchymal transition (EMT).
Melissa Skibba +6 more
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Epoxyeicosatrienoic Acid Analog EET-A Blunts Development of Lupus Nephritis in Mice [PDF]
Frontiers in Pharmacology, 2019 Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disorder that causes life threatening renal disease and current therapies are limited with serious side-effects.
Md. Abdul Hye Khan +4 more
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11,12 and 14,15 epoxyeicosatrienoic acid rescue deteriorated wound healing in ischemia. [PDF]
PLoS ONE, 2019 IntroductionEpoxyeicosatrienoic acids (EETs) are able to enhance angiogenesis and regulate inflammation that is especially important in wound healing under ischemic conditions.
Katharina Sommer +6 more
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Renal And Cardiovascular Actions Of 20-Hydroxyeicosatetraenoic Acid And Epoxyeicosatrienoic Acids [PDF]
Clinical and Experimental Pharmacology and Physiology, 2000 SUMMARY1. Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)‐dependent pathways to epoxyeicosatrienoic acids (EET) and 20‐hydroxyeicosatetraenoic acid (20‐HETE) in the kidney and the peripheral vasculature.2. The present short review summarizes the renal and cardiovascular actions of these important mediators.3. Epoxyeicosatrienoic acids are
, M Alonso-Galicia, D R Harder
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