Eicosanoids in human heart failure: pilot study of plasma epoxyeicosatrienoic and dihydroxyeicosatrienoic acid levels [PDF]
Archives of Medical Science, 2023 Introduction The role of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, remains unclear in human heart failure (HF). Material and methods We enrolled 50 patients with HF to measure plasma 14,15-EET and 14,15-DHET levels using ...
Petr Kala +4 more
doaj +4 more sources
14,15-Dihydroxyeicosatrienoic acid, a soluble epoxide hydrolase metabolite in blood, is a predictor of anthracycline-induced cardiotoxicity – a hypothesis generating study [PDF]
Cardio-Oncology, 2023 Background Early identification of patients susceptible to chemotherapy-induced cardiotoxicity could lead to targeted treatment to reduce cardiac dysfunction.
Julia Matzenbacher dos Santos +4 more
doaj +4 more sources
The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. [PDF]
Lipids Health Dis, 2013 Abstract Background 14,15-Epoxyeicosatrienoic acids (14,15-EETs) generated from arachidonic acid by cytochrome P450 epoxygenases have beneficial effects in certain cardiovascular diseases, and increased 14,15-EET levels protect the cardiovascular system.
Yang T +5 more
europepmc +4 more sources
Epoxyeicosatrienoic Acids and Dihydroxyeicosatrienoic Acids Are Potent Vasodilators in the Canine Coronary Microcirculation [PDF]
Circulation Research, 1998 Abstract —Cytochrome P 450 epoxygenases convert arachidonic acid into 4 epoxyeicosatrienoic acid (EET) regioisomers, which were recently identified as endothelium-derived hyperpolarizing factors in coronary blood vessels.
Neal L Weintraub +2 more
exaly +3 more sources
Life Sciences, 2021 Pregnancy is associated with numerous changes in physiological and metabolic processes to ensure successful progression to full term. One such change is the alteration of arachidonic acid (AA) metabolism and formation of eicosanoids. This study explores the changes in AA metabolites formed through the cytochrome P450 mediated pathway to ...
Emily Fay +2 more
exaly +4 more sources
Effects of Angiotensin II Receptor Blockers on Serum Levels of Epoxyeicosatrienoic Acids and Dihydroxyeicosatrienoic Acids in Patients Admitted to a Cardiovascular Center [PDF]
European Journal of Clinical Pharmacology, 2021 Abstract Purpose Several clinical studies have demonstrated that angiotensin-converting enzyme inhibitors, but not angiotensin II receptor blockers (ARBs), reduce the risk of non-fatal myocardial infarction and cardiovascular mortality.
Takaki Toda, Yuji Mukai, Anders Rane
exaly +3 more sources
Prostaglandins and Other Lipid Mediators, 2022 Estimates of heritability are the first step in identifying a trait with substantial variation due to genetic factors. Large-scale genetic analyses can identify the DNA variants that influence the levels of circulating lipid species and the statistical technique Mendelian randomisation can use these DNA variants to address potential causality of these ...
Bernard Keavney +2 more
exaly +4 more sources
Transpulmonary eicosanoid metabolite gradients: insights into metabolic flux of pro- and anti-inflammatory metabolites and lung function [PDF]
ERJ Open ResearchIntroduction Eicosanoids are upstream lipid mediators of inflammatory pathways. Transpulmonary gradient (ΔEIC) analysis using multisite sampling enables physiological assessment of metabolic flux across the lungs.
Louisa A. Mounsey +8 more
doaj +2 more sources
Biological and Pharmaceutical Bulletin, 2015 Epoxyeicosatrienoic acids (EETs) are produced primarily by CYPs from arachidonic acid (AA) and then further metabolized to the corresponding dihydroxyeicosatrienoic acids (DHETs). EETs play important roles in physiological processes such as regulating vasodilation and inflammation.
Takaki Toda, Yuji Mukai, Erik Eliasson
exaly +4 more sources
Regulation of P450-derived epoxy fatty acids in cardiovascular diseases [PDF]
Redox Biochemistry and ChemistryThe cytochrome P450 (P450 or CYP) superfamily, while extensively recognized for xenobiotic metabolism, is also critically involved in the biosynthesis of lipid mediators from polyunsaturated fatty acids (PUFAs).
Matthew L. Edin +2 more
doaj +2 more sources