Results 31 to 40 of about 2,730,714 (181)

The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS

Journal of Lipid Research, 2002
A method for the simultaneous quantification of urinary linoleic and arachidonic acid derived epoxides and diols, as well as the arachidonate omega hydroxylated product has been developed. The method employs negative mode electrospray ionization and HPLC
John W. Newman, Takaho Watanabe, Bruce D. Hammock   +2 more
doaj   +1 more source

Oxygenation of arachidonic acid by hepatic microsomes of the rabbit. Mechanism of biosynthesis of two vicinal dihydroxyeicosatrienoic acids.

Biochimica et biophysica acta, 1982
[1-14C] Arachidonic (eicosatetraenoic) acid was incubated at 37 degrees C for 15 min with rabbit liver microsomes fortified with NADPH (1 mM). The products were purified by high-pressure liquid chromatography (HPLC) and analyzed by gas chromatography-mass spectrometry.
E H, Oliw, J A, Oates
openaire   +4 more sources

Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination

Vaccines, 2020
Tularemia is a highly infectious and contagious disease caused by the bacterium Francisella tularensis. To better understand human response to a live-attenuated tularemia vaccine and the biological pathways altered post-vaccination, healthy adults were ...
Kristal M. Maner-Smith, Johannes B. Goll, Manoj Khadka, Travis L. Jensen, Jennifer K. Colucci, Casey E. Gelber, Carolyn J. Albert, Steven E. Bosinger, Jacob D. Franke, Muktha Natrajan, Nadine Rouphael, Robert A. Johnson, Patrick Sanz, Evan J. Anderson, Daniel F. Hoft, Mark J. Mulligan, David A. Ford, Eric A. Ortlund   +17 more
doaj   +1 more source

Systemic N-Acylethanolamines and Other Lipid Mediators Are Associated With NSAID-Exacerbated Respiratory Disease. [PDF]

Clin Exp Allergy
Clinical &Experimental Allergy, Volume 56, Issue 1, Page 95-98, January 2026.
Salmi VE, Lyly A, Neuvonen M, Saarentaus E, Niemi M, Toppila-Salmi S.   +5 more
europepmc   +2 more sources

14,15-Dihydroxy-eicosa-5(Z)-enoic Acid Selectively Inhibits 14,15-Epoxyeicosatrienoic Acid-Induced Relaxations in Bovine Coronary Arteries [PDF]

, 2010
Cytochrome P-450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs). EETs relax vascular smooth muscle by membrane hyperpolarization.
Ishfaq A. Bukhari, Setti G. Jagadeesh, Bhavani Sangras, Kathryn M. Gauthier, William B. Campbell, J. R. Falck   +5 more
core   +1 more source

TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function

Scientific Reports, 2021
Oxylipins modulate the behavior of immune cells in inflammation. Soluble epoxide hydrolase (sEH) converts anti-inflammatory epoxyeicosatrienoic acid (EET) to dihydroxyeicosatrienoic acid (DHET). An sEH-inhibitor, TPPU, has been demonstrated to ameliorate
Christian B. Bergmann, Bruce D. Hammock, Debin Wan, Falk Gogolla, Holly Goetzman, Charles C. Caldwell, Dorothy M. Supp   +6 more
doaj   +1 more source

8,9‐Dihydroxyeicosatrienoic acid does not protect the glomerular filtration barrier

The FASEB Journal, 2009
Introduction Focal segmental glomerulosclerosis (FSGS) leads to end‐stage renal disease. A circulating factor is believed to cause the primary glomerular lesion in FSGS. We have shown that 8,9‐epoxyeicosatrienoic acid (8,9‐EET) protects the glomerular filtration barrier function against the FSGS factor ...
Mukut Sharma, Ellen T McCarthy, Virginia J Savin, Paresh Patel, Sean Shaw, John R Falck, John D Imig   +6 more
openaire   +1 more source

Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets

Journal of Lipid Research, 2013
The dose-responsiveness of plasma oxylipins to incremental dietary intake of arachidonic acid (20:4n-6; ARA) and docosahexaenoic acid (22:6n-3; DHA) was determined in piglets. Piglets randomly received one of six formulas (n = 8 per group) from days 3 to
Maaike J. Bruins, Adrie D. Dane, Katrin Strassburg, Rob J. Vreeken, John W. Newman, Norman Salem, Jr., Cynthia Tyburczy, J.Thomas Brenna   +7 more
doaj   +1 more source

Profiling inflammatory markers in patients with pneumonia on intensive care [PDF]

, 2018
Clinical investigations lack predictive value when diagnosing pneumonia, especially when patients are ventilated and develop ventilator associated pneumonia (VAP). New tools to aid diagnosis are important to improve outcomes.
Holmes, Elaine, Gordon, AC, Wolfer, Arnaud, Antcliffe, David, Takata, Masao, O'Dea, Kieran   +5 more
core   +1 more source

The concentrations of TPPU and regulatory lipid mediators involved in the CYP450 pathway in plasma.

, 2022
The graphs in panels A and B show the concentrations of TPPU and 14,15-DiHETrE, respectively, in plasma. All data are shown as the mean ± SEM (n = 6–8). The asterisks (*) denote significant (p p < 0.05) differences among the other three groups, according
Wei Li (7081), Jason Chen (15937), Savannah Mack (12436810), Bowen Tan (7125179), Debin Wan (1996066), Kent E. Pinkerton (12290), Ziping Chen (11568016), Jun Yang (2084), Jingjing Zhang (163589), Minoru Takeuchi (12436816), Bruce D. Hammock (65754), Karen Wagner (496387), Kaori Tsuji (12436813), Chuanzhen Zhang (5698283), Chang Wang (328274), Xiyuan Li (1307673), Ching-Wen Wu (2514637)   +16 more
core   +1 more source