Results 21 to 30 of about 2,730,714 (181)

Electroacupuncture Ameliorates Scopolamine-Induced Dry Eye Disease in Mice by Restoring Lacrimal Gland Lipid Homeostasis and Reducing IL-1β/IL-18 Expression. [PDF]

J Immunol Res
Dry eye disease (DED) can lead to severe eye discomfort, which manifests as dryness, pain and decreased vision, and significantly affects daily life. This study elucidated the effects of electroacupuncture (EA) intervention on DED and clarified its potential mechanisms through changes in lacrimal gland lipid metabolism and inflammation.
Liang S, Ji T, Wu X, Wu Y, Wei Q, Ding N.   +5 more
europepmc   +2 more sources

Correction to: Effects of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids in patients admitted to a cardiovascular center [PDF]

European Journal of Clinical Pharmacology, 2021
A Correction to this paper has been published: 10.1007/s00228-021-03092-2
Yuka Kato, Asuna Senda, Yuji Mukai, Miki Yamashita, Yuki Sasaoka, Minayo Hanada, Fuminori Hongo, Mitsugu Hirokami, Anders Rane, Nobuo Inotsume, Takaki Toda   +10 more
openaire   +1 more source

A Linchpin Approach to Unsaturated Fatty Acids:  11,12-Epoxyeicosatrienoic Acid and 11S,12S-Dihydroxyeicosatrienoic Acid Ethyl Esters [PDF]

The Journal of Organic Chemistry, 2005
[Chemical reaction: See text] A "linchpin" coupling strategy is described for the construction of long-chain fatty acid metabolites. This strategy led to a short synthesis of the ethyl esters of both 11,12-epoxyeicosatrienoic acid (EET) and 11S,12S-dihydroxyeicosatrienoic acid (DHET).
Douglass F, Taber, Zhe, Zhang
openaire   +2 more sources

Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways

Environment International, 2021
Background: Exposure to ambient air particulate matter (PM) is a risk factor for cardiometabolic diseases. The knowledge of the underlying mechanisms is still evolving, but systemic inflammation and oxidative stress are central to the ability of PM to ...
Teng Wang, Yiqun Han, Haonan Li, Yanwen Wang, Tao Xue, Xi Chen, Wu Chen, Yunfei Fan, Xinghua Qiu, Jicheng Gong, Yifan Xu, Junxia Wang, Weiju Li, Tong Zhu   +13 more
doaj   +1 more source

Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). [PDF]

PLoS ONE, 2013
Inflammation is a key element in many cardiovascular diseases. Both estrogen loss, caused by menopause, and aging have inflammatory consequences. Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp)
Alison R Lee, Angela S Pechenino, Hua Dong, Bruce D Hammock, Anne A Knowlton   +4 more
doaj   +1 more source

Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo

Journal of Lipid Research, 2013
Monocyte chemoattractant protein-1 (MCP-1)-induced monocyte chemotaxis is a major event in inflammatory disease. Our prior studies have demonstrated that MCP-1-dependent chemotaxis requires release of arachidonic acid (AA) by activated cytosolic ...
Suman Kundu, Talat Roome, Ashish Bhattacharjee, Kevin A. Carnevale, Valentin P. Yakubenko, Renliang Zhang, Sung Hee Hwang, Bruce D. Hammock, Martha K. Cathcart   +8 more
doaj   +1 more source

Arachidonic acid cytochrome P450 epoxygenase pathway

Journal of Lipid Research, 2009
Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, 5,6-, 8,9-, 11,12-, and 14,15-EET, that function as autacrine and paracrine mediators.
Arthur A. Spector
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation. [PDF]

Adv Sci (Weinh)
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Waltl L, Holubek D, Speck K, Wildermuth R, Haut FL, Permann S, Plangger I, Steinborn C, Rao Z, D'Avino D, Cerqua I, Stadler J, Roviezzo F, Schlenke P, Siller A, Schennach H, Koeberle SC, Pferschy-Wenzig EM, Rossi A, Magauer T, Koeberle A.   +20 more
europepmc   +2 more sources

Epoxyeicosatrienoic Acids and/or Their Metabolites Promote Hypoxic Response of Cells

Journal of Pharmacological Sciences, 2008
Epoxyeicosatrienoic acids (EETs), including 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET, are produced by cytochrome P450 (P450) such as CYP2C8 and 2C9; and they are hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by epoxide hydrolase.
Sachiko Suzuki, Ami Oguro, Mayuko Osada-Oka, Yoshihiko Funae, Susumu Imaoka   +4 more
doaj   +1 more source

Flavonoids as Modulators of Lipid Mediator Signaling: A Narrative Review on Mechanisms, Current Evidence, and Gaps in the Literature. [PDF]

Mol Nutr Food Res
Flavonoid consumption may modulate phospholipase activity and COX‐, LOX‐, and CYP450‐dependent oxylipin biosynthesis, reshaping lipid mediator networks. Emerging evidence suggests these shifts may favor inflammatory resolution over propagation, with implications for metabolic, cardiovascular, and neuroinflammatory disease risk.
Arballo J, Lila MA.
europepmc   +2 more sources