Results 41 to 50 of about 2,730,714 (181)
CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina
International Journal of Cardiology: Heart & Vasculature, 2017 Background: Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease.
Tomonori Akasaka +15 more
doaj +1 more source
Inside epoxyeicosatrienoic acids and cardiovascular disease
Frontiers in Pharmacology, 2014 Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions. Importantly, CYP epoxygenase-derived EETs are involved in the maintenance of cardiovascular homeostasis.
Stefania eTacconelli, Paola ePatrignani
doaj +1 more source
14,15-Epoxyeicosatrienoic acid metabolism in endothelial cells.
Journal of Lipid Research, 1993 Epoxyeicosatrienoic acid (EET) metabolism was studied in endothelial cells to determine whether this tissue may influence their vasoactive properties. Porcine aortic endothelial cells rapidly took up all four EET regioisomers.
M VanRollins +3 more
doaj +1 more source
Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids
International Journal of Vascular Medicine, 2012 Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their ...
Scott J. Thomson +2 more
doaj +1 more source
, 2016 A “linchpin” coupling strategy is described for the construction of long-chain fatty acid metabolites. This strategy led to a short synthesis of the ethyl esters of both 11,12-epoxyeicosatrienoic acid (EET) and 11S,12S-dihydroxyeicosatrienoic acid (DHET)
Douglass F. Taber (1568878) +1 more
core +1 more source
CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators
Molecules, 2022 Inflammation plays a crucial role in the initiation and development of a wide range of systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) metabolized by CYP450 epoxygenase (CYP450) and are subsequently hydrolyzed ...
Zeqi Shi, Zuowen He, Dao Wen Wang
doaj +1 more source
, 2013 Bar graphs of each individual subject’s % change in the following eicosapentaenoic acid (EPA, 20:5n3) metabolites (subjects ordered by direction and magnitude of response on x axis): A) the lipoxygenase metabolite 12-hydroxyeicosapentaenoic acid (12-HEPE)
Ronald J. Hogg (476305) +9 more
core +1 more source
Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.
PLoS ONE, 2017 Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes +8 more
doaj +1 more source
Oxylipin Profiles in Plasma of Patients with Wilson’s Disease
Metabolites, 2020 Wilson’s disease (WD) is a rare autosomal recessive metabolic disorder resulting from mutations in the copper-transporting, P-type ATPase gene ATP7B gene, but influences of epigenetics, environment, age, and sex-related factors on the WD phenotype ...
Nadezhda V. Azbukina +8 more
doaj +1 more source