Results 51 to 60 of about 2,730,714 (181)

Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK_Cachannels: implications for soluble epoxide hydrolase inhibition [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2006
Epoxyeicosatrienoic acids (EETs) are metabolized by soluble epoxide hydrolase (sEH) to form dihydroxyeicosatrienoic acids (DHETs) and are putative endothelium-derived hyperpolarizing factors (EDHFs). EDHFs modulate microvascular tone; however, the chemical identity of EDHF in the human coronary microcirculation is not known. We examined the capacity of
Brandon T, Larsen, Hiroto, Miura, Ossama A, Hatoum, William B, Campbell, Bruce D, Hammock, Darryl C, Zeldin, John R, Falck, David D, Gutterman   +7 more
openaire   +2 more sources

Altered Release of Cytochrome P450 Metabolites of Arachidonic Acid in Renovascular Disease

, 2008
The aim of the present cross-sectional study was to investigate whether activation of the renin-angiotensin system in renovascular disease affects the cytochrome P450 ω/ω-1 hydroxylase (20-hydroxyeicosatetraenoic acid [20-HETE]) and epoxygenase ...
RICCI, Matteo, FAVA, Cristiano, P. Patrignani, A. Morganti, J. C. McGiff, H. Jiang, L. Turolo, MINUZ, Pietro, S. Tacconelli, A. Lechi, MINUZ P, LECHI A, FAVA C, MCGIFF JC, TACCONELLI, Stefania, TUROLO L, JIANG H, PATRIGNANI, Paola, MORGANTI A, RICCI M   +19 more
core   +4 more sources

Soluble Epoxide Hydrolase Inhibition Prevents Experimental Type 4 Cardiorenal Syndrome

Frontiers in Molecular Biosciences, 2021
Objectives: Cardiovascular diseases (CVD) remain the leading cause of morbimortality in patients with chronic kidney disease (CKD). The aim of this study was to assess the cardiovascular impact of the pharmacological inhibition of soluble epoxide ...
Mouad Hamzaoui, Mouad Hamzaoui, Clothilde Roche, David Coquerel, Thomas Duflot, Thomas Duflot, Valery Brunel, Paul Mulder, Vincent Richard, Jérémy Bellien, Jérémy Bellien, Dominique Guerrot, Dominique Guerrot   +12 more
doaj   +1 more source

Comparison of the relative levels^a of metabolites of the arachidonic acid pathway in sera from BT and LL patients before and after antibiotic treatment.

, 2013
aAbsent values were substituted with the limit of detection, represented by the lowest intensity value of any given sample. Then, averaged values from the untreated BT serum samples (n = 4) were normalized to 100% and other samples were normalized ...
B. Brett Finlay (53559), Cristiana S. de Macedo (446238), Euzenir N. Sarno (157005), Maria das Graças M. O. Henriques (446242), Katherine A. Mattos (446239), Marcelo Ribeiro-Alves (184765), Jun Han (231645), André L. P. Candéa (446241), Julio J. Amaral (446236), Luis Caetano M. Antunes (446237), Christoph H. Borchers (159697), Jingxi Pan (446240), Maria Cristina V. Pessolani (446243), Patrícia T. Bozza (810038)   +13 more
core   +1 more source

Conversion of epoxyeicosatrienoic acids (EETs) to chain-shortened epoxy fatty acids by human skin fibroblasts

Journal of Lipid Research, 2000
Epoxyeicosatrienoic acids (EETs), the eicosanoid biomediators synthesized from arachidonic acid by cytochrome P450 epoxygenases, are inactivated in many tissues by conversion to dihydroxyeicosatrienoic acids (DHETs).
Xiang Fang, Terry L. Kaduce, Mike VanRollins, Neal L. Weintraub, Arthur A. Spector   +4 more
doaj   +1 more source

Panax notoginseng Saponins Accelerate Diabetic Wound Repair by Minimizing Mitochondrial Dysfunction and Inhibiting Pyroptosis of Macrophage via Regulating Ephx2/11,12‐EET Axis

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Panax notoginseng saponins (PNS) accelerate diabetic wound healing via targeting the Ephx2/11,12‐EET axis in macrophages. PNS inhibits Ephx2 expression to elevate 11,12‐EET levels, which restores mitochondrial homeostasis by regulating mitochondrial dynamic proteins, reduces mtROS production, and subsequently suppresses NLRP3 inflammasome‐mediated ...
Nan Chen, Bo Zhu, Cai‐hua Sun, Tong Hou   +3 more
wiley   +1 more source

PUFA and oxFA levels showing >1.5 or 0.67-fold changes and p<0.01 values between plasma and serum samples of either male or female subjects.

, 2014
(MFC (S/P), median fold change in serum/plasma; YM, young male, YF, young female; EM, elderly male; EF, elderly female; HHT, hydroxyheptadecatrienoic acid; HETE, hydroxyeicosatetraenoic acid; diHETE, dihydroxyeicosatetraenoic acid; diHETrE ...
Masaki Ishikawa (464116), Yuya Senoo (535675), Masayo Urata (535676), Yoshiro Saito (195372), Keiko Maekawa (535674), Mayumi Murayama (535677), Yoko Tajima (535678), Kosuke Saito (3031488), Yuji Kumagai (535679)   +8 more
core   +1 more source

Increases in Levels of Epoxyeicosatrienoic and Dihydroxyeicosatrienoic Acids (EETs and DHETs) in Liver and Heart in Vivo by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and in Hepatic EET:DHET Ratios by Cotreatment with TCDD and the Soluble Epoxide Hydrolase Inhibitor AUDA [PDF]

Drug Metabolism and Disposition, 2014
The environmental toxin and carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) binds and activates the transcription factor aryl hydrocarbon receptor (AHR), inducing CYP1 family cytochrome P450 enzymes. CYP1A2 and its avian ortholog CYP1A5 are highly active arachidonic acid epoxygenases.
Silvia, Diani-Moore, Yuliang, Ma, Steven S, Gross, Arleen B, Rifkind   +3 more
openaire   +2 more sources

Levels of representative lipid metabolites with significant matrix-associated differences.

, 2014
(A) 18∶0 lysoPC, (B) 36∶3 DG, (C) 5,6-diHEtrE, (D) 8-HETE. The graph shows medians and interquartile ranges.
Masaki Ishikawa (464116), Yuya Senoo (535675), Masayo Urata (535676), Yoshiro Saito (195372), Keiko Maekawa (535674), Mayumi Murayama (535677), Yoko Tajima (535678), Kosuke Saito (3031488), Yuji Kumagai (535679)   +8 more
core   +1 more source

Role of Polyunsaturated Fatty Acids (PUFAs) and Eicosanoids on Dry Eye Symptoms and Signs

Biomolecules
Polyunsaturated fatty acids (PUFAs) generate pro- and anti-inflammatory eicosanoids via three different metabolic pathways. This study profiled tear PUFAs and their metabolites and examined the relationships with dry eye (DE) and meibomian gland ...
Simran Mangwani-Mordani, Amanda Prislovsky, Daniel Stephenson, Charles E. Chalfant, Anat Galor, Nawajes Mandal   +5 more
doaj   +1 more source