Results 71 to 80 of about 2,730,714 (181)
A perspective: PLA2G4A as drug target for vascular inflammation in Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract Anti‐amyloid therapies for Alzheimer's disease (AD) modestly slow cognitive decline but carry significant risk of amyloid‐related imaging abnormalities (ARIAs), brain swelling, and hemorrhage, particularly in apolipoprotein E ε4 carriers. Cerebral amyloid angiopathy (CAA) and vascular inflammation drive this vulnerability, highlighting the ...
Ambreen Kanwal +12 more
wiley +1 more source
Epoxyeicosatrienoic acids protect pancreatic beta cells against pro-inflammatory cytokine toxicity [PDF]
, 2019 Pro-inflammatory cytokines contribute to pancreatic beta cell death in the pathogenesis of type 1 diabetes mellitus (DM). Cytochrome P450-derived epoxyeicosatrienoic acids (EETs), produced by selective epoxidation of arachidonic acid, display anti ...
Watson
core +1 more source
Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies
Psychiatry and Clinical Neurosciences, Volume 80, Issue 4, Page 241-249, April 2026.Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda +4 more
wiley +1 more source
Heat maps of lipid molecules among fasted rats of different age groups.
, 2014 The heat maps were generated with statistically significant different lipid molecules ...
Masaki Ishikawa (464116) +8 more
core +1 more source
, 1988 Renal cytochrome P-450-dependent monooxygenases metabolize arachidonic acid to products some of which affect vascular tone and (Na+,K+)ATPase activity.
MCGIFF J.C. +3 more
core +2 more sources
Exploration, Volume 6, Issue 1, February 2026.Circadian rhythm of epoxides and its diols in the kidney and plasma showed a significant light–dark manner. Furthermore, circadian disruption by timed‐imposed of EpSA from thermo‐induced oxidized oil during the inactive phase impaired renal function. ABSTRACT Modulation of circadian rhythms impairs homeostasis, resulting in altered susceptibility to ...
Yanjun Liu +6 more
wiley +1 more source
Heat maps of lipid molecules among fasted male and female rats.
, 2014 The heat maps were generated with statistically significant different lipid molecules ...
Masaki Ishikawa (464116) +8 more
core +1 more source
Maximal exercise and plasma cytochrome P450 and lipoxygenase mediators: a lipidomics study
Physiological Reports, 2019 Epoxides derived from arachidonic acid (AA) are released during exercise and may contribute to vasodilation. However, exercise may also affect circulating levels of other epoxides derived from cytochromes P450 (CYP) monooxygenase and lipoxygenase (LOX ...
Benjamin Gollasch +4 more
doaj +1 more source
Advanced Science, Volume 13, Issue 5, 27 January 2026.A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo +10 more
wiley +1 more source
, 2022 Panel A shows a heatmap of the lipidomic profiles involved in CYP450, COX, and LOX pathways from each exposure group. Panel B shows a volcano plot comparing lipids in the OVA and OVA + TPPU (2 h) treatment groups.
Wei Li (7081) +16 more
core +1 more source