Results 61 to 70 of about 2,730,714 (181)

Correlation between arachidonic acid metabolites and vascular endothelial dysfunction in Chinese elderly with type 2 diabetes mellitus

Cardiology Plus, 2016
Objective: This study was carried out to determine the correlation between arachidonic acid metabolites and vascular endothelial dysfunction in older Chinese patients diagnosed with type 2 diabetes mellitus.
Yali Huang, Tong Lu
doaj   +1 more source

Non-Targeted Metabolomic Profiling of Coronary Heart Disease Patients With Taohong Siwu Decoction Treatment

Frontiers in Pharmacology, 2020
Traditional Chinese medicine is one of the complementary and alternative therapies to improve the prognosis of coronary heart disease (CHD). Taohong Siwu Decoction (THSWD), a classical traditional Chinese medication that promotes blood circulation, is ...
Tianqi Tao, Tao He, Huimin Mao, Xudong Wu, Xiuhua Liu   +4 more
doaj   +1 more source

Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D3 Supplementation in High Iodide Intake–Induced Hypothyroid Offspring Rats

Frontiers in Physiology, 2021
Aim: This study aimed to investigate the potential role of fatty acids in high iodide intake–induced hypothyroidism and its complications and also in the intervention of iodide intake adjustment and 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] supplementation.
Qing Liu, Yue Zhang, Hailing Zhao, Xiaomei Yao   +3 more
doaj   +1 more source

Differential metabolomic signatures in plasma and urine under mild and moderate hypothermia during cardiopulmonary bypass

Scientific Reports
While the organ-protective effects of hypothermia during cardiopulmonary bypass (CPB) are well known, the metabolomic impacts of different hypothermia levels remain unclear. This study aimed to evaluate the effects of mild (32–35 °C, n = 15) and moderate
Oguzhan Durmaz, Cemil Can Eylem, Evren Ozcinar, Emirhan Nemutlu, Osman Dag, Burak Derkus, Emel Emregul   +6 more
doaj   +1 more source

Topliss‐Guided Optimization of Acetanilide‐Based Soluble Epoxide Hydrolase Inhibitors: Exploring the Pentafluorosulfanyl Group as a Potency‐Enhancing Motif

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Can an amide analog retain the high potency of the classic urea motif in soluble epoxide hydrolase inhibitors? Through a single unconventional switch, the introduction of the underexplored pentafluorosulfanyl group into an amide analog of TPPU, the authors restored high inhibitory potency.
Alba López‐Ruiz, Eugènia Pujol, Cristian Ramos, Valeria Rizzo, Christophe Morisseau, Cristina Val, Tiziana Ginex, Javier Vázquez, Sandra Codony, Andreea L. Turcu, Belén Pérez, Elena Sáez, Antonio Pineda‐Lucena, Bruce D. Hammock, F. Javier Luque, M. Isabel Loza, José Brea, Santiago Vázquez   +17 more
wiley   +1 more source

Western diet effects on hepatic ω6-PUFA derived oxylipins.

, 2019
ω6-PUFA derived oxylipins were quantified using a targeted LC/MS approach (Materials and methods). A: ω6 PUFA-derived oxylipins in RD-fed mice. B: Diet effects on ω6 PUFA-derived oxylipins. Results are presented as fold change in oxylipins induced by the
Melinda H. Spooner (6551933), Weijian Zhang (446407), Manuel Garcia-Jaramillo (6551930), Donald B. Jump (498480), Christiane V. Löhr (418937), Carmen P. Wong (512550)   +5 more
core   +1 more source

Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system. [PDF]

PLoS ONE, 2015
Palmitoylethanolamide (PEA), a peroxisome proliferator-activated receptor-α agonist, has been demonstrated to reduce blood pressure and kidney damage secondary to hypertension in spontaneously hypertensive rat (SHR).
Giuseppina Mattace Raso, Claudio Pirozzi, Roberta d'Emmanuele di Villa Bianca, Raffaele Simeoli, Anna Santoro, Adriano Lama, Francesca Di Guida, Roberto Russo, Carmen De Caro, Raffaella Sorrentino, Antonio Calignano, Rosaria Meli   +11 more
doaj   +1 more source

Elevated n-3/n-6 PUFA ratio in early life diet reverses adverse intrauterine kidney programming in female rats

Journal of Lipid Research, 2022
Intrauterine growth restriction (IUGR) predisposes to chronic kidney disease via activation of proinflammatory pathways, and omega-3 PUFAs (n-3 PUFAs) have anti-inflammatory properties.
Jenny Voggel, Gregor Fink, Magdalena Zelck, Maria Wohlfarth, Julia M. Post, Laura Bindila, Manfred Rauh, Kerstin Amann, Miguel A. Alejandre Alcázar, Jörg Dötsch, Kai-Dietrich Nüsken, Eva Nüsken   +11 more
doaj   +1 more source

Epoxygenase metabolites of arachidonic acid inhibit vasopressin response in toad bladder

, 1987
In addition to cyclooxygenase and lipoxygenase pathways, the kidney can also metabolize arachidonic acid by a NADPH-dependent cytochrome P-450 enzyme to epoxyeicosatrienoic acids (EETs); furthermore, 5,6-EET has been shown to alter electrolyte transport
J. A. Oates, S. D. Levine, M. Jacoby, E. Petty, D. Schlondorff   +4 more
core   +1 more source

Oxylipin Profiling of Alzheimer’s Disease in Nondiabetic and Type 2 Diabetic Elderly

Metabolites, 2019
Oxygenated lipids, called “oxylipins,” serve a variety of important signaling roles within the cell. Oxylipins have been linked to inflammation and vascular function, and blood patterns have been shown to differ in type 2 diabetes (T2D ...
Jill K. Morris, Brian D. Piccolo, Casey S. John, Zachary D. Green, John P. Thyfault, Sean H. Adams   +5 more
doaj   +1 more source