Results 81 to 90 of about 2,730,714 (181)

Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids

, 1999
Cytochrome P-450-derived epoxyeicosatrienoic acids (EETs) are avidly incorporated into and released from endothelial phospholipids, a process that results in potentiation of endothelium-dependent relaxation.
Terry L. Kaduce, Papri Chatterjee, Neal L. Weintraub, Mike VanRollins, Xiang Fang, Arthur A. Spector   +5 more
core   +1 more source

Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth

Redox Biology, 2020
Nitro-oleate (10-nitro-octadec-9-enoic acid), which inhibits soluble epoxide hydrolase (sEH) by covalently adducting to C521, increases the abundance of epoxyeicosatrienoic acids (EETs) that can be health promoting, for example by lowering blood pressure
Hyun-Ju Cho, Christopher Harry Switzer, Alisa Kamynina, Rebecca Charles, Olena Rudyk, Tony Ng, Joseph Robert Burgoyne, Philip Eaton   +7 more
doaj   +1 more source

Dihydroxyeicosatrienoic acids are potent activators of Ca²⁺‐activated K⁺ channels in isolated rat coronary arterial myocytes

The Journal of Physiology, 2001
1. Dihydroxyeicosatrienoic acids (DHETs), which are metabolites of arachidonic acid (AA) and epoxyeicosatrienoic acids (EETs), have been identified as highly potent endogenous vasodilators, but the mechanisms by which DHETs induce relaxation of vascular smooth muscle are unknown. Using inside-out patch clamp techniques, we examined the effects of DHETs
T, Lu, P V, Katakam, M, VanRollins, N L, Weintraub, A A, Spector, H C, Lee   +5 more
openaire   +3 more sources

Fluorescent HPLC assay for 20-HETE and otherP-450 metabolites of arachidonic acid

, 2000
This study describes a fluorescent HPLC assay for measuring 20-hydroxyeicosatetraenoic acid (20-HETE) and other cytochrome P-450 metabolites of arachidonic acid in urine, tissue, and interstitial fluid. An internal standard, 20-hydroxyeicosa-6( Z),15( Z)-
Kristopher G. Maier, Magdalena Alonso-Galicia, John R. Falck, Lisa Henderson, Jayashree Narayanan, Richard J. Roman   +5 more
core   +1 more source

Hemodialysis and erythrocyte epoxy fatty acids

Physiological Reports, 2020
Fatty acid products derived from cytochromes P450 (CYP) monooxygenase and lipoxygenase (LOX)/CYP ω/(ω‐1)‐hydroxylase pathways are a superclass of lipid mediators with potent bioactivities.
Benjamin Gollasch, Guanlin Wu, Tong Liu, Inci Dogan, Michael Rothe, Maik Gollasch, Friedrich C. Luft   +6 more
doaj   +1 more source

Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice. [PDF]

PLoS ONE, 2016
AIM:20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis.
Ye Zhu, Maximilian Blum, Uwe Hoff, Tim Wesser, Mandy Fechner, Christina Westphal, Dennis Gürgen, Rusan Ali Catar, Aurelie Philippe, Kaiyin Wu, Gordana Bubalo, Michael Rothe, Steven M Weldon, Duska Dragun, Wolf-Hagen Schunck   +14 more
doaj   +1 more source

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

Advanced Science, Volume 12, Issue 42, November 13, 2025.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin, Weijia Gu, Xiaomei Tong, Mengru Lai, Yi Zhang, Na Liu, Xiaoying Jin, Chao Li, Dong Huang, Feng Zhou, Yongdong Dai, Songying Zhang   +11 more
wiley   +1 more source

Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase

, 2003
Three genes cloned from Fundulus heteroclitus (killifish) define a new P450 subfamily, CYP2P. Structurally, the CYP2Ps are related to fish CYP2Ns and mammalian CYP2Js. CYP2P transcripts are expressed predominantly in liver and intestine.
Oleksiak, Marjorie F, Wu, Shu, Qu, Wei, Cox, Rachel, Stegeman, John J, Zeldin, Darryl C, Parker, Carol   +6 more
core   +1 more source

Omega-3 Fatty Acid Intake and Oxylipin Production in Response to Short-Term Ambient Air Pollution Exposure in Healthy Adults

Toxics
Oxylipins are specialized lipid mediators that can have dual functions, either promoting inflammation or supporting resolution. Exposure to air pollution is associated with systemic inflammation that may be modified by oxylipins derived from ...
Hao Chen, Siqi Zhang, Xiannen Pan, Alexandra Schneider, David Diaz-Sanchez, James Samet, Haiyan Tong   +6 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibition Protected against Angiotensin II-induced Adventitial Remodeling

Scientific Reports, 2017
Epoxyeicosatrienoic acids (EETs), the metabolites of cytochrome P450 epoxygenases derived from arachidonic acid, exert important biological activities in maintaining cardiovascular homeostasis.
Chi Zhou, Jin Huang, Qing Li, Jiali Nie, Xizhen Xu, Dao Wen Wang   +5 more
doaj   +1 more source