Results 101 to 110 of about 2,730,714 (181)

Mid-gestation serum lipidomic profile associations with spontaneous preterm birth are influenced by body mass index.

PLoS ONE, 2020
Spontaneous preterm birth (sPTB) is a major cause of infant morbidity and mortality. While metabolic changes leading to preterm birth are unknown, several factors including dyslipidemia and inflammation have been implicated and paradoxically both low (30
Kamil Borkowski, John W Newman, Nima Aghaeepour, Jonathan A Mayo, Ivana Blazenović, Oliver Fiehn, David K Stevenson, Gary M Shaw, Suzan L Carmichael   +8 more
doaj   +1 more source

Allylic oxidation of ent-Kaurenic acid, ent-Kaurenic acid Methyl Ester and ent-Kaurenol. [PDF]

, 2015
En este artículo se presenta la oxidación alílica del ácido ent-kaurénico, del éster metílico del ácido entkaurénico y del ent-kaurenol. La reacción se realizó utilizando dioxano como solvente, a temperatura ambiente bajo agitación durante 4 horas.
Bahsas B., Alí H., Usubillaga, Alfredo, Aparicio Z., Rosa L.   +2 more
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Regulation ofP-450 4A activity in the glomerulus of the rat

, 1999
We recently reported that an enzyme of the cytochrome P-450 4A family is expressed in the glomerulus, but there is no evidence that 20-hydroxyeicosatetraenoic acid (20-HETE) can be produced by this tissue.
Osamu Ito, Richard J. Roman
core   +1 more source

Metabolic signatures and predictive biomarkers of liposomal doxorubicin-induced hypersensitivity in breast cancer: A pilot study

Cancer Treatment and Research Communications
Background: Liposomal doxorubicin hypersensitivity significantly affects breast cancer patients, with widely varying incidence rates (9 % to 46 %). Despite its efficacy, this condition poses a critical barrier to treatment due to the need for precise ...
Xiaorong Su, Yiyin Weng, Yiqi Xiao, Lizhu Weng, Yanbin Zeng, Wanlong Lin, Wei Zhuang   +6 more
doaj   +1 more source

Different mechanisms of acute versus long‐term antihypertensive effects of soluble epoxide hydrolase inhibition: Studies in Cyp1a1‐Ren‐2 transgenic rats [PDF]

, 2014
Recent studies have shown that the long-term antihypertensive action of soluble epoxide hydrolase inhibition (sEH) in angiotensin-II (AngII)-dependent hypertension might be mediated by the suppression of intrarenal AngII levels.
Sporková, Alexandra, Kompanowska‐Jezierska, Elzbieta, Hammock, Bruce D, Kramer, Herbert J, Jíchová, Šárka, Imig, John D, Nishiyama, Akira, Hwang, Sung H, Červenka, Luděk, Sadowski, Janusz, Kopkan, Libor, Husková, Zuzana   +11 more
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Angiotensin II Regulates Adrenal Vascular Tone Through Zona Glomerulosa Cell–Derived EETs and DHETs

, 2011
Elevated concentrations of aldosterone are associated with several cardiovascular diseases. Angiotensin II (Ang II) increases aldosterone secretion and adrenal blood flow.
Phillip G. Kopf, John R. Falck, Kathryn M. Gauthier, William B. Campbell, David X. Zhang   +4 more
core   +1 more source

High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways

Frontiers in Nutrition
Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammation, and hepatocyte damage. A Western-style diet characterized by excessive n-6 polyunsaturated fatty acid (n-6 PUFA) intake, which is metabolized to pro-inflammatory ...
Jian-Tong, Meng-Ting Zhou, Xiang-Zhun Song, Liu Yang, Yu-Hui Fang, Lan Liu, Jing-Shu Cui, Xiao-Chen Lu, Hai-Yang Zhu, Ying-Bin Jin, Hong-Mei Han   +10 more
doaj   +1 more source

Epoxyeicosatrienoic Acid Agonist Regulates Human Mesenchymal Stem Cell–Derived Adipocytes Through Activation of HO-1-pAKT Signaling and a Decrease in PPARγ

, 2010
Human mesenchymal stem cells (MSCs) expressed substantial levels of CYP2J2, a major CYP450 involved in epoxyeicosatrienoic acid (EET) formation. MSCs synthesized significant levels of EETs (65.8±5.8pg=mg protein) and dihydroxyeicosatrienoic acids (DHETs) (
Koduru, Sreenivasulu Reddy, Nader G. Abraham, Angela Burgess, Inoue, Kazuyoshi, Michal L. Schwartzman, John R. Falck, Sreenivasulu Reddy Koduru, Burgess, Angela, Dong Hyun Kim, Katherine Gotlinger, Abraham, Nader G., Zeldin, Darryl C., Falck, John R., Gotlinger, Katherine, Manthati, Vijaya Lingam, Darryl C. Zeldin, Vanella, Luca, Schwartzman, Michal L., Kazuyoshi Inoue, Vijaya Lingam Manthati, Kim, Dong Hyun, Luca Vanella   +21 more
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Heat maps of lipid molecules among rats subjected to different feeding conditions.

, 2014
The heat maps were generated with statistically significant different lipid molecules ...
Masaki Ishikawa (464116), Yuya Senoo (535675), Masayo Urata (535676), Yoshiro Saito (195372), Keiko Maekawa (535674), Mayumi Murayama (535677), Katsuko Toyoshima (655669), Kosuke Saito (3031488), Yuji Kumagai (535679)   +8 more
core   +1 more source

Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats,”DrugMetabolism and Disposition

, 2008
: Several cytochrome P450 (P450) enzymes have been identified in the heart, and their levels have been reported to be altered during cardiac hypertrophy.
Mona E Aboutabl, Ayman O S El-Kadi, Beshay N M Zordoky   +2 more
core   +1 more source