Results 111 to 120 of about 2,730,714 (181)

Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations

, 2012
Immunoglobulin A nephropathy (IgAN) is a leading cause of chronic kidney disease, frequently associated with hypertension and renal inflammation. ω-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in fish oil (FO) improve kidney ...
Hammock, BD, Nording, Malin,, O´Sullivan, A, Hegedus, C, Hogg, RJ, Weiss, RH, Zivkovic, AM, Yang, J, Bay, C   +8 more
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Increased Soluble Epoxide Hydrolase in Human Gestational Tissues from Pregnancies Complicated by Acute Chorioamnionitis

Mediators of Inflammation, 2019
Chorioamnionitis (CAM) is primarily a polymicrobial bacterial infection involving chorionic and amniotic membranes that is associated with increased risk of preterm delivery.
Tai-Ho Hung, Szu-Fu Chen, Chun-Hu Wu, Chuan-Chi Kao, Chung-Pu Wu   +4 more
doaj   +1 more source

Profiling lipid mediators in serum from children with H1N1 influenza

Scientific Reports
Influenza A virus subtype H1N1 can cause severe acute respiratory distress syndrome and death in young children and elderly individuals. H1N1 initiates inflammatory responses that aim to contain and eliminate microbial invaders.
Weijun Chen, Yitao Gu, Yongjun Ma, Lele Dong, Liangxuan Pan, Chai Ji, Lanlan Guo, Lianxin Qi, Yuanyuan Zhang, Fei Gao   +9 more
doaj   +1 more source

14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E₂production in vascular smooth muscle cells

, 1998
14,15-Epoxyeicosatrienoic acid (EET), a cytochrome P-450 epoxygenase product of arachidonic acid (AA), reduced PGE2formation by 40–75% in porcine aortic and murine brain microvascular smooth muscle cells.
Terry L. Kaduce, Steven A. Moore, Neal L. Weintraub, Lynn L. Stoll, Xiang Fang, Gretchen Rich, Arthur A. Spector   +6 more
core   +1 more source

Scientific Opinion on Erucic acid in feed and food

, 2016
Erucic acid is the trivial name of the fatty ...
Barregård, L., E. Dogliotto, (contam), EFSA Panelon Contaminants in the Food Chain, Laakso, J., M. Rose, L. Hoogenboom, Wallace, H., C. Hogstrand, Oswald, I., M. Dinovi, H.K. Knutsen, Nebbia, C.S., Ruiz, J.A.G., Baert, K., S. Ceccatelli, C.S. Nebbia, A. Petersen, Vollmer, G., Dogliotti, E., Varga, E., Bignami, M., H. Wallace, EFSA Panel on Contaminants in the Food Chain (CONTAM), Sousa, R., B. Derr, J. Laakso, Dinovi, M., Rose, M., A.C. Roudot, B. Brüschweiler, M. Bignami, M. Metzler, Petersen, A., Grasl-Kraupp, B., Hoogenboom, L., K. Baert, B. Grasl-Kraupp, L. Velasco, J.A. Gomez Ruiz, Hogstrand, C., Cottrill, B., Knutsen, H.K., Roudot, A.-C., Vleminckx, C., I. Oswald, E. Varga, Dörr, B., Brüschweiler, B., C. Vleminckx, Edler, L., J. Alexander, T. Schwerdtle, Alexander, J., L. Edler, B. Cottrill, Metzler, M., Velasco, L., Schwerdtle, T., L. Barregard, G. Vollmer, Ceccatelli, S.   +60 more
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Cytochrome P450-dependent arachidonic acid metabolism in human kidney

, 1990
Cytochrome P450-dependent arachidonic acid metabolism in human kidney. Cytochrome P450-dependent arachidonic acid metabolism in human kidney cortex from several postmortem subjects has been characterized.
Levere, Richard D., Schwartzman, Michal L., Goodman, Alvin I., Rios, Amelia R., Solangi, Karim, Abraham, Nader G., Martasek, Pavel   +6 more
core   +1 more source

Insights into the potential role of sEH inhibition in the prevention and progression of neurological disorders

Endocrine and Metabolic Science
Neurological disorders are associated with decreased blood supply to the brain, neuronal damage, oxidative stress, and inflammation. While treatments are limited, soluble epoxide hydrolase inhibitors can be useful in alleviating neurological disorders ...
Mamatha Gavisiddaiah, Sumanta Kumar Goswami, Manali Somanna, Bruce D. Hammock, Kenganora Mruthunjaya, Abigail Fielding, Dithu Thekkekkara, Santhepete Nanjundaiah Manjula   +7 more
doaj   +1 more source

Diabetic vascular calcification inhibited by soluble epoxide hydrolase gene deletion via regressing NID2-mediated IGF2-ERK1/2 signaling pathway

Chinese Medical Journal
. Background:. Epoxyeicosatrienoic acids (EETs), which are metabolites of arachidonic acid catalyzed by cytochrome P450 epoxygenase, are degraded into inactive dihydroxyeicosatrienoic acids by soluble epoxide hydrolase (sEH).
Yueting Cai, Shuiqing Hu, Jingrui Liu, Jinlan Luo, Wenhua Li, Jiaxin Tang, Siyang Liu, Ruolan Dong, Yan Yang, Ling Tu, Xizhen Xu, Rongman Jia   +11 more
doaj   +1 more source

The renal cytochrome P450 system generates novel arachidonic acid metabolite

, 1989
The generation of prostaglandins and other oxygenated metabolites of arachidonic acid (AA) is a complex process initiated by the release of ester-ified AA from cellular lipids.
CARROLL M.A., ABRAHAM N. G., CARROLL M. A., SCHWARTZMAN M. L., MCGIFF J.C., MCGIFF J. C., D. SACERDOTI, SCHWARTZMAN M.L., SACERDOTI, DAVID, ABRAHAM N.G., Nader G. Abraham, David Sacerdoti, Mairead A. Carroll, John C. McGiff, Michal Schwartzman   +14 more
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Intraperitoneally injected d11-11(12)-epoxyeicosatrienoic acid is rapidly incorporated and esterified within rat plasma and peripheral tissues but not the brain [PDF]

Epoxyeicosatrienoic acids (EpETrEs) are bioactive lipid mediators of arachidonic acid cytochrome P450 oxidation. In vivo, the free (unbound) form of EpETrEs regulate multiple processes including blood flow, angiogenesis and inflammation resolution.
Da Costa Souza, Felipe, Taha, Ameer Y, Kusumoto, Ibuki, Watanabe, Sho, Shen, Qing, Nitin, Nitin, Lein, Pamela J   +6 more
core   +1 more source