Results 11 to 20 of about 2,730,714 (181)

Lipid metabolites and nitric oxide production in the cerebrospinal fluid and plasma of dogs with meningoencephalitis of unknown origin and idiopathic epilepsy: a pilot study [PDF]

Frontiers in Veterinary Science
IntroductionIdiopathic epilepsy (IE) and meningoencephalomyelitis of unknown origin (MUO) are common causes of brain diseases leading to seizures in dogs.
Tomohiro Yonezawa, Tomohiro Yonezawa, Shinya Takenouchi, Tomoki Motegi, Michiyo Miyazaki, Nanae Nagata, Koji Kobayashi, Koji Kobayashi, Masaki Yamada, Takahisa Murata, Takahisa Murata, Takahisa Murata   +11 more
doaj   +4 more sources

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis [PDF]

Journal of Lipid Research, 2018
Omega-6 FAs are inflammatory mediators that are increased in joints with osteoarthritis (OA), but their association with OA progression is not yet well defined.
Ana M. Valdes, Srinivasarao Ravipati, Petros Pousinis, Cristina Menni, Massimo Mangino, Abhishek Abhishek, Victoria Chapman, David A. Barrett, Michael Doherty   +8 more
doaj   +2 more sources

Impact of Genetic Polymorphisms in CYP2C8 and Rosiglitazone Intake on the Urinary Excretion of Dihydroxyeicosatrienoic Acids

Pharmacogenomics, 2008
The cytochrome P450 enzymes CYP2C8, CYP2C9 and CYP2J2 generate 8,9-, 11,12-, and 14,15-epoxyeicosatrienic acid (EET) from arachidonic acid, and these EETs are then hydrolyzed to dihydroxyeicosatrienoic acids (DHET) before excretion into the urine.
Kirchheiner, Julia, Meineke, Ingolf, Fuhr, Uwe, Rodriguez-Antona, Cristina, Lebedeva, Elena V., Brockmoeller, Juergen   +5 more
openaire   +4 more sources

A Liquid Chromatography/Mass Spectrometric Method for Simultaneous Analysis of Arachidonic Acid and Its Endogenous Eicosanoid Metabolites Prostaglandins, Dihydroxyeicosatrienoic Acids, Hydroxyeicosatetraenoic Acids, and Epoxyeicosatrienoic Acids in Rat Brain Tissue [PDF]

Journal of Pharmaceutical and Biomedical Analysis, 2007
A sensitive, specific, and robust liquid chromatography/mass spectrometric (LC/MS) method was developed and validated that allows simultaneous analysis of arachidonic acid (AA) and its cyclooxygenase, cytochrome P450, and lipoxygenase pathway metabolites prostaglandins (PGs), dihydroxyeicosatrienoic acids (DiHETrEs), hydroxyeicosatetraenoic acids ...
Mary Barbe, Kenneth I Strauss, Susan A Jansen   +2 more
exaly   +3 more sources

8,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice. [PDF]

PLoS ONE, 2012
Epoxyeicosatrienoic acids (EETs), synthesized from arachidonic acid by cytochrome P450 epoxygenases, are converted to dihydroxyeicosatrienoic acids by soluble epoxide hydrolase. EETs exert anti-inflammatory effects. However, the effect of EETs on humoral
Yanxiang Gao, Juan Feng, Kongyang Ma, Zhou Zhou, Yi Zhu, Qingbo Xu, Xian Wang   +6 more
doaj   +2 more sources

Effect of weaning strategies on biosynthesis of oxylipids in Holstein dairy calves [PDF]

JDS Communications
The aim of this study was to determine the effect of the weaning calves at 2 ages (early vs. late) and 2 weaning paces (abrupt over 3 d vs. gradual over 14 d) on plasma oxylipids.
A.R. Wolfe, B.C. Agustinho, M. Mahdavi-Yekta, G.A. Contreras, D.E. Konetchy, A.H. Laarman, P. Rezamand   +6 more
doaj   +2 more sources

Assessing the therapeutic potential of PDE-5 inhibitors in adults: Insights from a multi-omics study. [PDF]

Physiol Rep
Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
McGovern KA, Wright TJ, Marchant ED, Kilroe SP, Durham WJ, Dillon EL, Baum MM, Kinsky MP, Russell WK, Fry CS, Gongloor P, Pyles RB, Urban RJ, Rasmussen BB, Sheffield-Moore M.   +14 more
europepmc   +2 more sources

Fecal Lipid Metabolites and Microbiota Alterations in Dogs With Concurrent Atopic Dermatitis and Adverse Food Reaction. [PDF]

Allergy
Allergy, Volume 81, Issue 7, Page 2549-2552, July 2026.
Hayashi A, Kakiyama S, Kawano K, Harima-Mizusawa N, Kobayashi T, Kaga C, Kobayashi K, Murata T.   +7 more
europepmc   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high-fat diet-induced obese mice. [PDF]

FEBS Open Bio
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Goda T, Sugimoto S, Cho C, Konishi M, Inoue N, Miyagaki S, Kawabe Y, Okamura T, Hamaguchi M, Nakajima H, Fukui M, Shinohara M, Iehara T.   +12 more
europepmc   +2 more sources

The Roles of EETs in Neurological Disorders [PDF]

CNS Neurosci Ther
Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Tang R, Li M, Hu B, Fei G, Zheng H, Wang X, Ding J.   +6 more
europepmc   +2 more sources