Results 11 to 20 of about 2,734,900 (203)

The expression of cytochrome P4502J2 gene and 14, 15 epoxyeicosatrienoic acid level influence the amount of insulin secreted from human mesenchymal stem cell-derived insulin-producing cells

Bulletin of the National Research Centre, 2018
Background Insulin-producing cells differentiated from human mesenchymal stem cells demonstrate limited glucose-stimulated insulin secretion. Cytochrome P450 2J2 and its product epoxyeicosatrienoic acids regulate β-cell function in the human pancreas ...
Loaa A. Tag Eldeen, Marow El Sheikh, Salwa Faisal   +2 more
doaj   +2 more sources

Inside epoxyeicosatrienoic acids and cardiovascular disease [PDF]

Frontiers in Pharmacology, 2014
Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions. Importantly, CYP epoxygenase-derived EETs are involved in the maintenance of cardiovascular homeostasis. In fact, in addition to their potent vasodilating effect, EETs have potent anti-inflammatory properties ...
TACCONELLI, Stefania, PATRIGNANI, Paola
openaire   +5 more sources

Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids [PDF]

International Journal of Vascular Medicine, 2012
Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).
Scott J. Thomson, Ara Askari, David Bishop-Bailey   +2 more
core   +5 more sources

8,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice. [PDF]

PLoS ONE, 2012
Epoxyeicosatrienoic acids (EETs), synthesized from arachidonic acid by cytochrome P450 epoxygenases, are converted to dihydroxyeicosatrienoic acids by soluble epoxide hydrolase. EETs exert anti-inflammatory effects. However, the effect of EETs on humoral
Yanxiang Gao, Juan Feng, Kongyang Ma, Zhou Zhou, Yi Zhu, Qingbo Xu, Xian Wang   +6 more
doaj   +2 more sources

Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions [PDF]

Frontiers in Physiology, 2010
Epoxyeicosatrienoic acids (EETs) contribute importantly to the regulation of vascular tone and blood pressure control. The purpose of this study was to develop stable EET analogs and test their in vivo blood pressure lowering effects in hypertensive rats.
John D Imig, Ahmed eElmarakby, Kasem eNithipatikom, Shouzou eWei, Jorge H Capdevila, Venugopal R Tuniki, Bhavani eSangras, Siddam eAnjaiah, Vijaya L Manthati, D. Sudarashan Reddy, John R Falck   +10 more
doaj   +2 more sources

Aging, Estrogen Loss and Epoxyeicosatrienoic Acids (EETs) [PDF]

PLoS ONE, 2013
Inflammation is a key element in many cardiovascular diseases. Both estrogen loss, caused by menopause, and aging have inflammatory consequences. Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp) enzymes from arachidonic acid.
Lee, Alison R, Pechenino, Angela S, Dong, Hua, Hammock, Bruce D, Knowlton, Anne A   +4 more
openaire   +7 more sources

The Hunt for the Putative Epoxyeicosatrienoic Acid Receptor. [PDF]

ACS Chem Biol
Epoxyeicosatrienoic acids, or EETs, are signaling molecules formed by the metabolism of arachidonic acid by cytochrome P450 enzymes. They are well-known for their anti-inflammatory effects, their ability to lower blood pressure, and benefits to cardiovascular outcomes.
Arnold WR, Jain S, Sinha V, Das A.
europepmc   +3 more sources

Intraperitoneally injected d11-11(12)-epoxyeicosatrienoic acid is rapidly incorporated and esterified within rat plasma and peripheral tissues but not the brain. [PDF]

Prostaglandins Leukot Essent Fatty Acids
Epoxyeicosatrienoic acids (EpETrEs) are bioactive lipid mediators of arachidonic acid cytochrome P450 oxidation. In vivo, the free (unbound) form of EpETrEs regulate multiple processes including blood flow, angiogenesis and inflammation resolution.
Watanabe S, Souza FDC, Kusumoto I, Shen Q, Nitin N, Lein PJ, Taha AY.   +6 more
europepmc   +2 more sources

Orally Active Epoxyeicosatrienoic Acid Analogs. [PDF]

J Cardiovasc Pharmacol, 2017
Abstract: Biologically active epoxyeicosatrienoic acid (EET) regioisomers are synthesized from arachidonic acid by cytochrome P450 epoxygenases of endothelial, myocardial, and renal tubular cells. EETs relax vascular smooth muscle and decrease inflammatory cell adhesion and cytokine release.
Campbell WB, Imig JD, Schmitz JM, Falck JR.   +3 more
europepmc   +4 more sources

The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling [PDF]

Frontiers in Physiology, 2021
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450 (CYP) epoxygenases, which include four regioisomers: 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. Each of them possesses beneficial effects against inflammation, fibrosis, and apoptosis, which could combat cardiovascular diseases.
Jinsheng Lai, Chen Chen
openaire   +3 more sources