Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats [PDF]
Frontiers in Pharmacology, 2019 Epoxyeicosatrienoic acids (EETs) and their analogs have been identified as potent antihypertensive compounds with cardio- and renoprotective actions. Here, we examined the effect of EET-A, an orally active EET analog, and c-AUCB, an inhibitor of the EETs
Jaroslav Hrdlička +17 more
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Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2 [PDF]
Journal of Lipid Research, 2019 Epoxyeicosatrienoic acids (EETs) are formed from the metabolism of arachidonic acid by cytochrome P450s. EETs promote angiogenesis linked to tumor growth in various cancer models that is attenuated in vivo by cyclooxygenase 2 (COX-2) inhibitors.
Amy A. Rand +7 more
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Stem cell-secreted 14,15- epoxyeicosatrienoic acid rescues cholesterol homeostasis and autophagic flux in Niemann–Pick-type C disease [PDF]
Experimental and Molecular Medicine, 2018 Inherited metabolic disease: Restoring motor function by reducing cholesterol An acid secreted by stem cells can reduce the excess cholesterol caused by a genetic metabolic disorder.
Insung Kang +10 more
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Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity [PDF]
International Journal of Molecular Sciences, 2021 Md Abdul Hye Khan +2 more
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Epoxyeicosatrienoic acid activation moderates endothelial mesenchymal transition to reduce obstructive nephropathy [PDF]
Kidney Research and Clinical Practice, 2017 Babu J. Padanilam
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The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling [PDF]
Frontiers in Physiology, 2021 Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450 (CYP) epoxygenases, which include four regioisomers: 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. Each of them possesses beneficial effects against inflammation, fibrosis, and apoptosis, which could combat cardiovascular diseases.
Jinsheng Lai, Chen Chen
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Archives of Medical Science, 2023 Introduction The role of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, remains unclear in human heart failure (HF). Material and methods We enrolled 50 patients with HF to measure plasma 14,15-EET and 14,15-DHET levels using ...
Petr Kala +4 more
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Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system. [PDF]
PLoS ONE, 2015 Palmitoylethanolamide (PEA), a peroxisome proliferator-activated receptor-α agonist, has been demonstrated to reduce blood pressure and kidney damage secondary to hypertension in spontaneously hypertensive rat (SHR).
Giuseppina Mattace Raso +11 more
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Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid [PDF]
Prostaglandins and Other Lipid Mediators, 2017 Xiangshu Xiao +2 more
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Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids [PDF]
International Journal of Vascular Medicine, 2012 Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).
Scott J. Thomson +2 more
openaire +4 more sources