Results 31 to 40 of about 5,105 (168)
Arachidonic acid cytochrome P450 epoxygenase pathway
Journal of Lipid Research, 2009 Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, 5,6-, 8,9-, 11,12-, and 14,15-EET, that function as autacrine and paracrine mediators.
Arthur A. Spector
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Epoxyeicosatrienoic acids and endothelium-dependent responses [PDF]
Pflügers Archiv - European Journal of Physiology, 2010 Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in response to agonists such as bradykinin and acetylcholine or physical stimuli such as shear stress or cyclic stretch. In the vasculature, the EETs have biological actions that are involved in the regulation of vascular ...
William B, Campbell, Ingrid, Fleming
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Frontiers in Pharmacology, 2014 Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity.
Victor eSamokhvalov +8 more
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EPOXYEICOSATRIENOIC ACID ANALOG ATTENUATES ANGIOTENSIN II HYPERTENSION AND KIDNEY INJURY
Frontiers in Pharmacology, 2014 Epoxyeicosatrienoic acids (EETs) contribute to blood pressure regulation leading to the concept that EETs can be therapeutically targeted for hypertension and the associated end-organ damage.
Md. Abdul Hye Khan +3 more
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Epoxyeicosatrienoic Acids, Hypertension, and Kidney Injury [PDF]
Hypertension, 2015 Kidney disease afflicts 33 million in the United States, and chronic kidney disease (CKD) accounts for >$60 billion in Medicare costs.1,2 Hypertension afflicts 75 million in the United States, and significant portions of those patients develop CKD and progress to end-stage renal disease.1–5 Interestingly, resistant hypertension which is defined as ...
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Journal of Lipid Research, 2000 Epoxyeicosatrienoic acids (EETs), the eicosanoid biomediators synthesized from arachidonic acid by cytochrome P450 epoxygenases, are inactivated in many tissues by conversion to dihydroxyeicosatrienoic acids (DHETs).
Xiang Fang +4 more
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Epoxyeicosatrienoic acids and cardioprotection: The road to translation
Journal of Molecular and Cellular Cardiology, 2014 AbstractCardiovascular disease, including acute myocardial infarction (AMI), is the leading cause of morbidity and mortality globally, despite well-established treatments. The discovery and development of novel therapeutics that prevent the progression of devastating consequences following AMI are thus important in reducing the global burden of this ...
Oni-Orisan, Akinyemi +3 more
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Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress
Cell Reports, 2019 Summary: Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in ...
Xi-He Qin +11 more
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FEBS Open Bio, 2021 Cytochrome P450 2A6 (CYP2A6) is an important metabolic enzyme and is involved in the progression of hepatocellular carcinoma (HCC). However, its specific function and the mechanism of modulation remain to be elucidated.
Tao Jiang +6 more
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Epoxyeicosatrienoic acids and glucose homeostasis in mice and men [PDF]
Prostaglandins & Other Lipid Mediators, 2016 Epoxyeicosatrienoic acids (EETs) are formed from arachidonic acid by the action of P450 epoxygenases (CYP2C and CYP2J). Effects of EETs are limited by hydrolysis by soluble epoxide hydrolase to less active dihydroxyeicosatrienoic acids. Studies in rodent models provide compelling evidence that epoxyeicosatrienoic acids exert favorable effects on ...
James M, Luther, Nancy J, Brown
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