Results 31 to 40 of about 2,734,900 (203)

Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity [PDF]

, 2011
Background: Arachidonic acid is metabolized through three major metabolic pathways, the cyclooxygenase, lipoxygenase and CYP450 enzyme systems. Unlike cyclooxygenase and lipoxygenases, the role of CYP450 epoxygenases in monocyte/macrophage-mediated ...
Bishop-Bailey, D, Mary C Sugden, David Bishop-Bailey, Bystrom, J, Holness Mark J., Sugden, MC, Mark J Holness, Holness, MJ, Jessica A. Wray, Wray, JA, Sugden, M C, Matthew L. Edin, Zeldin Darryl C., Zeldin, DC, Karen E Swales, Edin Matthew L., Edin, ML, Zeldin, D C, Sugden Mary C., Wray, J A, Gilroy Derek W., Swales Karen E., Darryl C Zeldin, Gilroy, DW, Derek W Gilroy, Karen E. Swales, Edin, M L, Mark J. Holness, Matthew L Edin, Derek W. Gilroy, Wray Jessica A., Gilroy, D W, Warner Timothy D., Jonas Bystrom, Warner, T D, Darryl C. Zeldin, Timothy D. Warner, Bishop-Bailey David, Bystrom Jonas, Holness, M J, Jessica A Wray, Swales, K E, Warner, TD, Timothy D Warner, Swales, KE, Mary C. Sugden   +45 more
core   +1 more source

Not so EEZE:the ‘EDHF’ antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries [PDF]

, 2004
P-450 metabolites, including the epoxyeicosatrienoic acids, are likely candidates for endothelial derived hyperpolarising factor (EDHF). In the present study, we confirm that the stable analogue 11-nonyloxyundec-8(Z)-enoic acid is a vasodilator of murine
MacKenzie, Louise Susan, Mitchell, Jane A., Falck, John R., Harrington, Louise S.; id_orcid, Falck, J.R.   +4 more
core   +2 more sources

14,15-Epoxyeicosatrienoic acid metabolism in endothelial cells.

Journal of Lipid Research, 1993
Epoxyeicosatrienoic acid (EET) metabolism was studied in endothelial cells to determine whether this tissue may influence their vasoactive properties. Porcine aortic endothelial cells rapidly took up all four EET regioisomers.
M VanRollins, TL Kaduce, HR Knapp, AA Spector   +3 more
doaj   +1 more source

Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells.

Journal of Lipid Research, 1995
Epoxyeicosatrienoic acids (EETs) are eicosanoids synthesized from arachidonic acid by the cytochrome P450 eposygenase pathway. The present studies demonstrate that 8,9-, 11,12-, and 14,15-EET are rapidly taken up by porcine aortic smooth muscle cells ...
X. Fang, M. VanRollins, T.L. Kaduce, A.A. Spector   +3 more
doaj   +1 more source

Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid. [PDF]

Prostaglandins Other Lipid Mediat, 2017
Liu X, Qian ZY, Xie F, Fan W, Nelson JW, Xiao X, Kaul S, Barnes AP, Alkayed NJ.   +8 more
europepmc   +2 more sources

Inhibition of Soluble Epoxide Hydrolase for Renal Health

Frontiers in Pharmacology, 2019
A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates.
Jun-Yan Liu, Jun-Yan Liu
doaj   +1 more source

Arachidonic acid cytochrome P450 epoxygenase pathway

Journal of Lipid Research, 2009
Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, 5,6-, 8,9-, 11,12-, and 14,15-EET, that function as autacrine and paracrine mediators.
Arthur A. Spector
doaj   +1 more source

Epoxyeicosatrienoic acids and endothelium-dependent responses [PDF]

Pflügers Archiv - European Journal of Physiology, 2010
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in response to agonists such as bradykinin and acetylcholine or physical stimuli such as shear stress or cyclic stretch. In the vasculature, the EETs have biological actions that are involved in the regulation of vascular ...
William B, Campbell, Ingrid, Fleming
openaire   +2 more sources

PPARγ SIGNALING IS REQUIRED FOR MEDIATING EETS PROTECTIVE EFFECTS IN NEONATAL CARDIOMYOCYTES EXPOSED TO LPS

Frontiers in Pharmacology, 2014
Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity.
Victor eSamokhvalov, Jelle eVriend, Jelle eVriend, Kristi L Jamieson, Maria eAkhnokh, Rajkumar eManne, John R Falck, John M. Seubert, John M. Seubert   +8 more
doaj   +1 more source

EPOXYEICOSATRIENOIC ACID ANALOG ATTENUATES ANGIOTENSIN II HYPERTENSION AND KIDNEY INJURY

Frontiers in Pharmacology, 2014
Epoxyeicosatrienoic acids (EETs) contribute to blood pressure regulation leading to the concept that EETs can be therapeutically targeted for hypertension and the associated end-organ damage.
Md. Abdul Hye Khan, John R Falck, William B Campbell, John D Imig   +3 more
doaj   +1 more source