Results 51 to 60 of about 2,734,900 (203)
Renal epoxyeicosatrienoic acid synthesis during pregnancy [PDF]
American Journal of Physiology-Renal Physiology, 2005 Epoxyeicosatrienoic acids (EETs), which belong to cytochrome P-450 (CYP)-derived eicosanoids, have been implicated to vasodilate renal arterioles, inhibit sodium transport in the nephron, and regulate blood pressure in several animal models. Because pregnancy is associated with changes of blood pressure, the aim of this study was to examine whether ...
Yiqiang, Zhou +5 more
openaire +2 more sources
14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles.
, 1991 Epoxygenase metabolites of arachidonic acid are produced by several tissues and have been shown to inhibit in vitro platelet aggregation. The purpose of the present investigation was to determine whether 14,15- or 8,9-epoxyeicosatrienoic acid ...
M L Heizer, J S McKinney, E F Ellis
core +1 more source
Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides
Journal of Lipid Research, 2004 CYP4F isoforms are involved in the oxidation of important cellular mediators such as leukotriene B4 (LTB4) and prostaglandins. The proinflammatory agent LTB4 and cytotoxic leukotoxins have been associated with several inflammatory diseases.
Valérie Le Quéré +4 more
doaj +1 more source
Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs
, 1989 Growth hormone secretion was stimulated in vitro by products of arachidonic acid epoxygenase, the epoxyeicosatrienoic acids. 5,6-Epoxyeicosatrienoic and 14,15-epoxyeicosatrienoic acid stimulated growth hormone release from an enriched population of ...
P. Yadagiri, G. D. Snyder, J. R. Falck
core +1 more source
Journal of Lipid Research, 2012 Pulmonary artery endothelial plexiform lesion is responsible for pulmonary vascular remodeling (PVR), a basic pathological change of pulmonary arterial hypertension (PAH).
Jun Ma +9 more
doaj +1 more source
, 2016 A “linchpin” coupling strategy is described for the construction of long-chain fatty acid metabolites. This strategy led to a short synthesis of the ethyl esters of both 11,12-epoxyeicosatrienoic acid (EET) and 11S,12S-dihydroxyeicosatrienoic acid (DHET)
Douglass F. Taber (1568878) +1 more
core +1 more source
Journal of Lipid Research, 2012 Epoxide hydrolases are a small superfamily of enzymes important for the detoxification of chemically reactive xenobiotic epoxides and for the processing of endogenous epoxides that act as signaling molecules.
Martina Decker +11 more
doaj +1 more source
Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress
Integrative Zoology, EarlyView.Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu +5 more
wiley +1 more source
, 2014 5,6-EET, 5,6-epoxyeicosatrienoic acid; 8,9-EET, 8,9-epoxyeicosatrienoic acid; 11,12-EET, 11,12-epoxyeicosatrienoic acid; 14,15-EET, 14,15-epoxyeicosatrienoic acid; 5,6-DHET, 5,6-dihydroxyeicosastrienoic acid; 8,9-DHET, 8,9-dihydroxyeicosastrienoic acid ...
Ye Zhu (646531) +5 more
core +1 more source
EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Cancer Science, EarlyView.Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source