Results 61 to 70 of about 2,734,900 (203)

Inducible CYP2J2 and its product 11,12-EET promotes bacterial phagocytosis : a role for CYP2J2 deficiency in the pathogenesis of Crohn's disease? [PDF]

, 2013
The epoxygenase CYP2J2 has an emerging role in inflammation and vascular biology. The role of CYP2J2 in phagocytosis is not known and its regulation in human inflammatory diseases is poorly understood. Here we investigated the role of CYP2J2 in bacterial
Bishop-Bailey, D, Jonas Bystrom (200256), David Bishop-Bailey, Bystrom, J, Andrew M. Smith, Thomson, Scott J., Andrew M. Smith (251118), Thomson, SJ, Johansson, Jörgen, Gilroy, Derek W., Matthew L. Edin, David Bishop-Bailey (200332), Zeldin, DC, Edin, ML, Zeldin, D C, Andrew M Smith, Derek W. Gilroy (200322), Darryl C Zeldin, Byström, Jonas, Smith, A M, Gilroy, DW, Derek W Gilroy, Jörgen Johansson (458315), Johansson, Jörgen,, Johansson, J, Edin, M L, Scott J. Thomson, Smith, Andrew M., Matthew L Edin, Derek W. Gilroy, Gilroy, D W, Zeldin, Darryl C., Scott J Thomson, Scott J. Thomson (458314), Thomson, S J, Jonas Bystrom, Darryl C. Zeldin (16449), Darryl C. Zeldin, Bishop-Bailey, David, Edin, Matthew L., Jörgen Johansson, Matthew L. Edin (200313), Smith, AM   +42 more
core   +1 more source

New Lipid Mediators in Retinal Angiogenesis and Retinopathy

Frontiers in Pharmacology, 2019
Retinal diseases associated with vascular destabilization and the inappropriate proliferation of retinal endothelial cells have major consequences on the retinal vascular network.
Ingrid Fleming, Ingrid Fleming
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling

Cell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen, Liangliang Liu, Xumeng Wang, Juanjuan Li, Jingyi Zhang, Xiaoli Shi, Qing Sun, Xu Chang, Jing Zhang, Jie Zhao, Fu Wang   +10 more
wiley   +1 more source

Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction[S]

Journal of Lipid Research, 2014
Herein, we characterize a generally applicable transformation of fatty acid epoxides by lipoxygenase (LOX) enzymes that results in the formation of a five-membered endoperoxide ring in the end product.
Tarvi Teder, William E. Boeglin, Alan R. Brash   +2 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders [PDF]

, 2016
Parkinson's disease (PD) is a multifactorial neurodegenerative disease involving oxidative stress, neuroinflammation and apoptosis. Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites and they play a role in cytoprotection by modulating ...
Lakkappa, Navya, Hammock, Bruce D, Krishnamurthy, Praveen T, Bharath, MM Srinivas, Velmurugan, D   +4 more
core   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Effects of 6‐OHDA‐Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10459-10474, November 2026.
ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W. Willows, Katharine W. Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F. Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W. Newman, Kristy L. Townsend   +15 more
wiley   +1 more source

Epoxyeicosatrienoic acid Metabolism in Preeclampsia

Cumhuriyet Medical Journal, 2018
Objective: Preeclampsia (PE) is a disease that characterized by hypertension and proteinuria during pregnancy. Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites which have vasodilatator, anti-inflammatory and profibrinolytic effects. Soluble epoxide hydrolase (sEH; EC 3.3.3.2) catalyses the degradation of EETs to their inactive diols ...
SARİ, İsmail, PINARBAŞI, Hatice, YILDIZ, Çağlar   +2 more
openaire   +3 more sources

Follicular fluid arachidonic acid and linoleic acid pathways.

, 2015
Abbreviations: COX: cyclooxygenase; CYP-450: cytochrome P–450; DiHETEs: dihydroxyeicosatetraenoic acids; EETs: epoxyeicosatrienoic acids; HETE: hydroxyeicosatetraenoic acid; HODE: hydroxyoctadecadienoic acid; LOX—lipoxygenase, LTX: lipoxin, PG ...
Tomasz Bączkowski (701378), Ewa Stachowska (701381), Rafał Kurzawa (701382), Anna Kazienko (701380), Arleta Drozd (701379), Przemysław Ciepiela (701377)   +5 more
core   +1 more source