Results 41 to 50 of about 2,734,900 (203)
Journal of Lipid Research, 2000 Epoxyeicosatrienoic acids (EETs), the eicosanoid biomediators synthesized from arachidonic acid by cytochrome P450 epoxygenases, are inactivated in many tissues by conversion to dihydroxyeicosatrienoic acids (DHETs).
Xiang Fang +4 more
doaj +1 more source
Epoxyeicosatrienoic Acids, Hypertension, and Kidney Injury [PDF]
Hypertension, 2015 Kidney disease afflicts 33 million in the United States, and chronic kidney disease (CKD) accounts for >$60 billion in Medicare costs.1,2 Hypertension afflicts 75 million in the United States, and significant portions of those patients develop CKD and progress to end-stage renal disease.1–5 Interestingly, resistant hypertension which is defined as ...
openaire +2 more sources
FEBS Open Bio, 2021 Cytochrome P450 2A6 (CYP2A6) is an important metabolic enzyme and is involved in the progression of hepatocellular carcinoma (HCC). However, its specific function and the mechanism of modulation remain to be elucidated.
Tao Jiang +6 more
doaj +1 more source
14,15-Dihydroxy-eicosa-5(Z)-enoic Acid Selectively Inhibits 14,15-Epoxyeicosatrienoic Acid-Induced Relaxations in Bovine Coronary Arteries [PDF]
, 2010 Cytochrome P-450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs). EETs relax vascular smooth muscle by membrane hyperpolarization.
Ishfaq A. Bukhari +5 more
core +1 more source
Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress
Cell Reports, 2019 Summary: Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in ...
Xi-He Qin +11 more
doaj +1 more source
Endothelium-Derived Epoxyeicosatrienoic Acids and Vascular Function [PDF]
Hypertension, 2006 Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases. The activation of CYP epoxygenases in endothelial cells is an important step in the NO and prostacyclin-independent vasodilatation of several vascular beds, and EETs have been identified as an endothelium-derived hyperpolarizing factor ...
Ingrid, Fleming, Rudi, Busse
openaire +2 more sources
Lipid regulation of BK channel function
Frontiers in Physiology, 2014 This mini-review focuses on lipid modulation of BK (MaxiK, BKCa) current by a direct interaction between lipid and the BK subunits and/or their immediate lipid environment.
Alex M. Dopico, Anna N. Bukiya
doaj +1 more source
The Metabolism of Epoxyeicosatrienoic Acids by Soluble Epoxide Hydrolase Is Protective against the Development of Vascular Calcification [PDF]
, 2020 International audienceThis study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes endothelium-derived epoxyeicosatrienoic acids, plays a role in vascular calcification. The sEH inhibitor trans-4-(4-(3-adamantan-1-yl-ureido)
Bellien, Jeremy +24 more
core +1 more source
Mechanism Underlying Endothelium-Dependent Relaxation by 2-Methylthio-ADP in Monkey Cerebral Artery
Journal of Pharmacological Sciences, 2010 We recently reported endothelium-dependent relaxation caused by nucleotides in the non-human primate cerebral artery. Here, we investigated the endothelium-dependent, nitric oxide- and prostanoid-independent relaxation induced by 2-methylthio-ADP ...
Ayman Geddawy +4 more
doaj +1 more source
New insights into epoxyeicosatrienoic acid-mediated protective effects in cardiac cells [PDF]
, 2014 Epoxyeicosatrienoic acids (EET) are cytochrome P450 epoxygenase metabolites of arachidonic acid. Evidence shows that they mediate protective effects in the cardiovascular system promoting cell survival.
Alsaleh, Nasser B
core +1 more source