Results 41 to 50 of about 5,105 (168)
Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions
Frontiers in Physiology, 2010 Epoxyeicosatrienoic acids (EETs) contribute importantly to the regulation of vascular tone and blood pressure control. The purpose of this study was to develop stable EET analogs and test their in vivo blood pressure lowering effects in hypertensive rats.
John D Imig +10 more
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Endothelium-Derived Epoxyeicosatrienoic Acids and Vascular Function [PDF]
Hypertension, 2006 Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases. The activation of CYP epoxygenases in endothelial cells is an important step in the NO and prostacyclin-independent vasodilatation of several vascular beds, and EETs have been identified as an endothelium-derived hyperpolarizing factor ...
Ingrid, Fleming, Rudi, Busse
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8,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice. [PDF]
PLoS ONE, 2012 Epoxyeicosatrienoic acids (EETs), synthesized from arachidonic acid by cytochrome P450 epoxygenases, are converted to dihydroxyeicosatrienoic acids by soluble epoxide hydrolase. EETs exert anti-inflammatory effects. However, the effect of EETs on humoral
Yanxiang Gao +6 more
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Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance This study furthers our understanding of epoxyeicosatrienoic acid metabolism by cyclooxygenase (COX) enzymes as a physiologically relevant metabolic pathway, producing signaling molecules that are angiogenic. It explains, in part, why inhibiting the soluble epoxide hydrolase (sEH) in some systems is angiogenic whereas ...
Amy A. Rand +6 more
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Mechanism Underlying Endothelium-Dependent Relaxation by 2-Methylthio-ADP in Monkey Cerebral Artery
Journal of Pharmacological Sciences, 2010 We recently reported endothelium-dependent relaxation caused by nucleotides in the non-human primate cerebral artery. Here, we investigated the endothelium-dependent, nitric oxide- and prostanoid-independent relaxation induced by 2-methylthio-ADP ...
Ayman Geddawy +4 more
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Lipid regulation of BK channel function
Frontiers in Physiology, 2014 This mini-review focuses on lipid modulation of BK (MaxiK, BKCa) current by a direct interaction between lipid and the BK subunits and/or their immediate lipid environment.
Alex M. Dopico, Anna N. Bukiya
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American Journal of Physiology - Heart and Circulatory Physiology, 2018 Jan Neckar +2 more
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Renal epoxyeicosatrienoic acid synthesis during pregnancy [PDF]
American Journal of Physiology-Renal Physiology, 2005 Epoxyeicosatrienoic acids (EETs), which belong to cytochrome P-450 (CYP)-derived eicosanoids, have been implicated to vasodilate renal arterioles, inhibit sodium transport in the nephron, and regulate blood pressure in several animal models. Because pregnancy is associated with changes of blood pressure, the aim of this study was to examine whether ...
Yiqiang, Zhou +5 more
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Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides
Journal of Lipid Research, 2004 CYP4F isoforms are involved in the oxidation of important cellular mediators such as leukotriene B4 (LTB4) and prostaglandins. The proinflammatory agent LTB4 and cytotoxic leukotoxins have been associated with several inflammatory diseases.
Valérie Le Quéré +4 more
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Journal of Lipid Research, 2012 Pulmonary artery endothelial plexiform lesion is responsible for pulmonary vascular remodeling (PVR), a basic pathological change of pulmonary arterial hypertension (PAH).
Jun Ma +9 more
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