Results 21 to 30 of about 5,105 (168)
Epoxyeicosatrienoic Acid Analogs and Vascular Function [PDF]
Current Medicinal Chemistry, 2010 Arachidonic acid metabolites, eicosanoids, are key contributors to vascular function and improper eicosanoid regulation contributes to the progression of cardiovascular diseases. Epoxyeicosatrienoic acids (EETs) are synthesized from arachidonic acid by epoxygenase enzymes to four regioisomers, 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. These EETs have
V, Sudhahar, S, Shaw, J D, Imig
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Soluble Epoxide Hydrolase Inhibition Prevents Experimental Type 4 Cardiorenal Syndrome
Frontiers in Molecular Biosciences, 2021 Objectives: Cardiovascular diseases (CVD) remain the leading cause of morbimortality in patients with chronic kidney disease (CKD). The aim of this study was to assess the cardiovascular impact of the pharmacological inhibition of soluble epoxide ...
Mouad Hamzaoui +12 more
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Vascular Pharmacology of Epoxyeicosatrienoic Acids [PDF]
, 2010 Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in responses to various stimuli such as the agonists acetylcholine (ACH) or bradykinin or by shear stress which activates phospholipase A(2) to release arachidonic acid.
Sandra L, Pfister +2 more
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Inside epoxyeicosatrienoic acids and cardiovascular disease [PDF]
Frontiers in Pharmacology, 2014 Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions. Importantly, CYP epoxygenase-derived EETs are involved in the maintenance of cardiovascular homeostasis. In fact, in addition to their potent vasodilating effect, EETs have potent anti-inflammatory properties ...
TACCONELLI, Stefania, PATRIGNANI, Paola
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Bulletin of the National Research Centre, 2018 Background Insulin-producing cells differentiated from human mesenchymal stem cells demonstrate limited glucose-stimulated insulin secretion. Cytochrome P450 2J2 and its product epoxyeicosatrienoic acids regulate β-cell function in the human pancreas ...
Loaa A. Tag Eldeen +2 more
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Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase
Journal of Lipid Research, 2012 Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has a C-terminus epoxide hydrolase domain and an N-terminus phosphatase domain. The endogenous substrates of epoxide hydrolase are known to be epoxyeicosatrienoic acids, but the endogenous ...
Ami Oguro, Susumu Imaoka
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14,15-Epoxyeicosatrienoic acid metabolism in endothelial cells.
Journal of Lipid Research, 1993 Epoxyeicosatrienoic acid (EET) metabolism was studied in endothelial cells to determine whether this tissue may influence their vasoactive properties. Porcine aortic endothelial cells rapidly took up all four EET regioisomers.
M VanRollins +3 more
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Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells.
Journal of Lipid Research, 1995 Epoxyeicosatrienoic acids (EETs) are eicosanoids synthesized from arachidonic acid by the cytochrome P450 eposygenase pathway. The present studies demonstrate that 8,9-, 11,12-, and 14,15-EET are rapidly taken up by porcine aortic smooth muscle cells ...
X. Fang +3 more
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The role of epoxyeicosatrienoic acids in the cardiovascular system [PDF]
British Journal of Clinical Pharmacology, 2015 There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors.
Yang, L +4 more
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Inhibition of Soluble Epoxide Hydrolase for Renal Health
Frontiers in Pharmacology, 2019 A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates.
Jun-Yan Liu, Jun-Yan Liu
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