Results 31 to 40 of about 7,307 (207)

Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors [PDF]

, 2022
Soluble epoxide hydrolase (sEH) is implicated as a potential therapeutic target for inflammation-related pathologies in the context of cardiovascular, central nervous system and metabolicdiseases.
Abdurrahman Olğaç, Christian Kretzer, Jordan, Paul M, Oliver Werz, Kretzer, Christian, Paul M. Jordan, Çapan, İrfan, Werz, Oliver, Banoglu, ERDEN, Olğaç, Abdurrahman, Çalışkan, Burcu, Erden Banoglu, İrfan Çapan, Burcu Çalışkan   +13 more
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Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies.
Aline Mello, Ming-Fo Hsu, Shinichiro Koike, Bryan Chu, Jeff Cheng, Jun Yang, Christophe Morisseau, Natalie J. Torok, Bruce D. Hammock, Fawaz G. Haj   +9 more
doaj   +1 more source

Isoprene Side-chain of SMTP is Essential for Soluble Epoxide Hydrolase Inhibition and Cellular Localization

Natural Product Communications, 2016
SMTPs, a family of natural small molecules that effectively treat ischemic stroke, are subject to clinical development. SMTPs enhance plasminogen activation and inhibit soluble epoxide hydrolase (sEH), leading to promotion of endogenous thrombolysis and ...
Shinya Otake, Norihiro Ogawa, Yoshikazu Kitano, Keiji Hasumi, Eriko Suzuki   +4 more
doaj   +1 more source

Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages

iScience, 2023
Summary: Soluble epoxide hydrolase is a widely distributed bifunctional enzyme that contains N-terminal phosphatase (N-phos) and C-terminal epoxide hydrolase (C-EH) domains.
Feng Liu, Xueying Diao, Haolun Cong, Eriko Suzuki, Keiji Hasumi, Hiroshi Takeshima   +5 more
doaj   +1 more source

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase [PDF]

, 2009
A class of potent non-urea inhibitors of soluble epoxide hydrolase was discovered via high throughput screening and SARs-guided modification. Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A
Yan, Fang, Xie, Yuli, Schürer, Stephan, Li, Xiangpo, Feng, Yan, Vidović, Dušica, Smith, Deborah H, Landry, Donald W, Gong, Gangli, Morisseau, Christophe, Deng, Shi-Xian, Hammock, Bruce D, Liu, Yidong, Rinderspacher, Alison, Branden, Lars, Zhu, Zhengxiang, Chung, Caty   +16 more
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Soluble Epoxide Hydrolase Inhibitors Regulate Ischemic Arrhythmia by Targeting MicroRNA-1

Frontiers in Physiology, 2021
Background: Soluble epoxide hydrolase inhibitors (sEHis) inhibit the degradation of epoxyeicosatrienoic acids (EETs) in cells, and EETs have antiarrhythmic effects.
Yanying Chen, Qiong Liu, Tian Yang, Li Shen, Danyan Xu   +4 more
doaj   +1 more source

Inhibition of Soluble Epoxide Hydrolase Reduces Paraquat Neurotoxicity in Rodents [PDF]

, 2022
Paraquat is one of the most common and acutely toxic herbicides used in developing nations, with epidemiological studies linking chronic paraquat exposure to Parkinson’s disease.
Atone, Jogen
core  

Bacterial Expression and HTS Assessment of Soluble Epoxide Hydrolase Phosphatase [PDF]

, 2022
S.689-694Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that possesses an epoxide hydrolase and lipid phosphatase activity (sEH-P) at two distinct catalytic domains.
Wolf, M., Klingler, F.-M., Gribbon, P., Proschak, E., Wittmann, S.   +4 more
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Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase

Current Issues in Molecular Biology, 2022
The quaternary isoquinoline alkaloids of palmatine (1), berberine (2), and jatrorrhizine (3) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC50 values of 29.6 ± 0.5, 33.4
Jang Hoon Kim, Chong Woon Cho, Mok Hur, Woo Tae Park, Youn-Ho Moon, Sung-Cheol Koo, Yun-Chan Hur, Jong Seong Kang, Ik Soo Lee   +8 more
doaj   +1 more source

Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: evidence for isozyme variants [PDF]

, 1999
Endogenous, constitutive soluble epoxide hydrolase in mice 3T3 cells was localized via immunofluorescence microscopy exclusively in peroxisomes, whereas transiently expressed mouse soluble epoxide hydrolase (from clofibrate-treated liver) accumulated ...
Mullen, Robert T, Hammock, Bruce D, Oesch, F, David F Grant, Arand, Michael; https://orcid.org/, Arand, Michael, Robert T Mullen, Franz Oesch, Richard N Trelease, Hammock, B D, Oesch, Franz, Heike Duerk, Trelease, Richard N, Grant, David F, Bruce D Hammock, Trelease, R N, Michael Arand, Duerk, Heike, Duerk, H, Mullen, R T, Grant, D F   +20 more
core   +1 more source