Results 31 to 40 of about 507,315 (208)

Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages

iScience, 2023
Summary: Soluble epoxide hydrolase is a widely distributed bifunctional enzyme that contains N-terminal phosphatase (N-phos) and C-terminal epoxide hydrolase (C-EH) domains.
Feng Liu, Xueying Diao, Haolun Cong, Eriko Suzuki, Keiji Hasumi, Hiroshi Takeshima   +5 more
doaj   +1 more source

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy [PDF]

, 2017
A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition
Charles G. Eberhart, Devraj, Kavi, Andreas Jungmann, Clemens Glaubitz, Fauser, Sascha, Fleming, Ingrid, Cheng, Zhixing, Dziumbla, Sarah, Sarah Dziumbla, Liya Wang, Jungmann, Andreas, Kavi Devraj, Akrit Sodhi, Awwad, Khader, Liebner, Stefan, Bruce D. Hammock, Hammes, Hans-Peter, Popp, Rüdiger, de Mos, Julian, Julian de Mos, Sodhi, Akrit, Eberhart, Charles G, Glaubitz, Clemens, Hans-Peter Hammes, Sven Zukunft, Ingrid Fleming, Hammock, Bruce D, Lin, Jihong, Oliver J. Müller, Jiong Hu, Zukunft, Sven, Frömel, Timo, Timo Frömel, Stefan Liebner, Rüdiger Popp, Hu, Jiong, Khader Awwad, Sofia-Iris Bibli, Zhixing Cheng, Müller, Oliver J, Jihong Lin, Sascha Fauser, Bibli, Sofia-Iris, Wang, Liya   +43 more
core   +1 more source

Soluble Epoxide Hydrolase Inhibitors Regulate Ischemic Arrhythmia by Targeting MicroRNA-1

Frontiers in Physiology, 2021
Background: Soluble epoxide hydrolase inhibitors (sEHis) inhibit the degradation of epoxyeicosatrienoic acids (EETs) in cells, and EETs have antiarrhythmic effects.
Yanying Chen, Qiong Liu, Tian Yang, Li Shen, Danyan Xu   +4 more
doaj   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources

Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase

Current Issues in Molecular Biology, 2022
The quaternary isoquinoline alkaloids of palmatine (1), berberine (2), and jatrorrhizine (3) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC50 values of 29.6 ± 0.5, 33.4
Jang Hoon Kim, Chong Woon Cho, Mok Hur, Woo Tae Park, Youn-Ho Moon, Sung-Cheol Koo, Yun-Chan Hur, Jong Seong Kang, Ik Soo Lee   +8 more
doaj   +1 more source

Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors [PDF]

, 2023
A series of soluble epoxide hydrolase (sEH) inhibitors containing halogenated pyrazoles was developed. Inhibition potency of the obtained compounds ranges from 0.8 to 27.5 nM.
Hammock, Bruce D, Butov, Gennady M, Danilov, Dmitry V, Burmistrov, Vladimir V, Dalinger, Igor L, Shkineva, Tatyana K, Gladkikh, Boris, Fayzullin, Robert R, Morisseau, Christophe, Dutova, Tatyana Ya, Gennady M. Butov, Dalinger, Igor L., Dutova, Tatyana Ya., Robert R. Fayzullin, Fayzullin, Robert R., Bruce D. Hammock, Boris Gladkikh, Christophe Morisseau, Burmistrov, Vladimir V., Danilov, Dmitry V., Tatyana Ya. Dutova, Vladimir V. Burmistrov, Tatyana K. Shkineva, Igor L. Dalinger, Dmitry V. Danilov, Hammock, Bruce D., Butov, Gennady M., Shkineva, Tatyana K.   +27 more
core   +1 more source

Soluble Epoxide Hydrolase Inhibition Prevents Experimental Type 4 Cardiorenal Syndrome

Frontiers in Molecular Biosciences, 2021
Objectives: Cardiovascular diseases (CVD) remain the leading cause of morbimortality in patients with chronic kidney disease (CKD). The aim of this study was to assess the cardiovascular impact of the pharmacological inhibition of soluble epoxide ...
Mouad Hamzaoui, Mouad Hamzaoui, Clothilde Roche, David Coquerel, Thomas Duflot, Thomas Duflot, Valery Brunel, Paul Mulder, Vincent Richard, Jérémy Bellien, Jérémy Bellien, Dominique Guerrot, Dominique Guerrot   +12 more
doaj   +1 more source

Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase

, 2022
S.1244-1249Multitarget ligands are interesting candidates for drug discovery and development due to improved safety and efficacy. However, rational design and optimization of multitarget ligands is tedious because affinity optimization for two or more ...
Hefke, L., Kramer, J.S., Zhu, W.F., Proschak, E., Hiesinger, K.   +4 more
core   +1 more source

Disrupting Dimerization Translocates Soluble Epoxide Hydrolase to Peroxisomes.

PLoS ONE, 2016
The epoxyeicosatrienoic acid (EET) neutralizing enzyme soluble epoxide hydrolase (sEH) is a neuronal enzyme, which has been localized in both the cytosol and peroxisomes.
Jonathan W Nelson, Anjali J Das, Anthony P Barnes, Nabil J Alkayed   +3 more
doaj   +1 more source

Protective Effects of the Soluble Epoxide Hydrolase Inhibitor 1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea in a Rat Model of Permanent Middle Cerebral Artery Occlusion

Frontiers in Pharmacology, 2020
Acute ischemic stroke is a serious disease that endangers human health. In our efforts to develop an effective therapy, we previously showed that the potent, highly selective inhibitor of soluble epoxide hydrolase called 1-trifuoromethoxyphenyl-3-(1 ...
Linlei Zhang, Linlei Zhang, Shasha Xu, Xiaoxiao Wu, Farah Mohamed Muse, Jiaou Chen, Yungang Cao, Jueyue Yan, Zicheng Cheng, Xingyang Yi, Zhao Han   +10 more
doaj   +1 more source