Results 51 to 60 of about 507,315 (208)

Supplementary Data from Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo

, 2009
Supplementary Data from Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in ...
Bruce D. Hammock (65754), Robert H. Weiss (14908509), Christophe Morisseau (362750), Jun-Yan Liu (192782), Sung Hee Hwang (495922), See-Hyoung Park (246508)   +5 more
core   +1 more source

Gene evolution of epoxide hydrolases and recommended nomenclature [PDF]

, 1995
We have analyzed amino acid sequence relationships among soluble and microsomal epoxide hydrolases, haloacid dehalogenases, and a haloalkane dehalogenase.
Shinozaki, K, Hammock, B D, Oesch, F, Kiyosue, T, Grant, D, Arand, Michael; https://orcid.org/, Beetham, J K, Pinot, F, Garbarino, J, Belknap, W R   +9 more
core   +1 more source

Role of soluble epoxide hydrolase in pain and depression comorbidity

Neurobiology of Disease
The coexistence of chronic pain and depression in clinical practice places a substantial social burden and profoundly impacts in patients. Although a clear correlation exists, the underlying mechanism of comorbidity between chronic pain and depression ...
Yuchen Bu, Siqi Yang, Di Wang, Suwan Hu, Qi Zhang, Zifeng Wu, Chun Yang   +6 more
doaj   +1 more source

Properties of epoxide hydrolase from the yeast Rhodotorula glutinis [PDF]

, 2002
Epoxide hydrolases are ubiquitous enzymes that can be found in nearly all living organisms. Some of the enzymes play an important role in detoxifying xenobiotic and metabolic compounds.
Ariës-Kronenburg, N.A.E.
core  

Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism

Scientific Reports, 2023
Integration of the omics data, including metabolomics and proteomics, provides a unique opportunity to search for new associations within metabolic disorders, including Alzheimer’s disease.
Kamil Borkowski, Nicholas T. Seyfried, Matthias Arnold, James J. Lah, Allan I. Levey, Chadwick M. Hales, Eric B. Dammer, Colette Blach, Gregory Louie, Rima Kaddurah-Daouk, John W. Newman   +10 more
doaj   +1 more source

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors

, 2022
Soluble epoxide hydrolase (sEH) is implicated as a potential therapeutic target for inflammation-related pathologies in the context of cardiovascular, central nervous system and metabolicdiseases.
Abdurrahman Olğaç, Christian Kretzer, Jordan, Paul M, Oliver Werz, Kretzer, Christian, Paul M. Jordan, Çapan, İrfan, Werz, Oliver, Banoglu, ERDEN, Olğaç, Abdurrahman, Çalışkan, Burcu, Erden Banoglu, İrfan Çapan, Burcu Çalışkan   +13 more
core   +1 more source

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

Chemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source

Cloning and application of epoxide hydrolases from yeasts [PDF]

, 2002
Epoxides are cyclic ethers that readily react with various nucleophilic compounds. Consequently, epoxides can be used in many chemical synthesis reactions. Two enantiomeric forms of an epoxide are possible if one of the carbon atoms is chiral. This means
Visser, J.H.
core  

Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. [PDF]

PLoS ONE, 2014
Acute pancreatitis (AP) is a frequent gastrointestinal disorder that causes significant morbidity, and its incidence has been progressively increasing. AP starts as a local inflammation in the pancreas that often leads to systemic inflammatory response ...
Ahmed Bettaieb, Samah Chahed, George Tabet, Jun Yang, Christophe Morisseau, Stephen Griffey, Bruce D Hammock, Fawaz G Haj   +7 more
doaj   +1 more source