Results 51 to 60 of about 7,307 (207)

Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death

Molecules
Nineteen potential mimics of 8,9-epoxyeicosatrienoic acid (8,9-EET), a natural bioactive oxylipin, were synthesized and evaluated for their ability to protect renal mesangial cells against sorafenib-induced cell death in a water-soluble tetrazolium (WST ...
Marcus de Bourg, Abhishek Mishra, Rawand S. Mohammad, Christophe Morisseau, Bruce D. Hammock, John D. Imig, Anders Vik   +6 more
doaj   +1 more source

A New Family of Subnanomolar inhibitors of Soluble Epoxide Hydrolase

The FASEB Journal, 2022
The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of epoxyeicosatrienoic acids, endogenous chemical mediators derived from arachidonic acid that show anti‐inflammatory and analgesic effects.
Escolano, Carmen, Bagán, Andrea, Turcu, Andreea L., Morisseau, Christophe, Loza, María Isabel, Brea, José Manuel, Bartra Cabré, Clara, Sanfeliu, Coral, Hammock, Bruce D., Vázquez, Santiago   +9 more
openaire   +2 more sources

Polycyclic compounds as soluble epoxide hydrolase inhibitors

Invention Disclosure
In this invention, a novel family of benzohomoadamantane-based soluble epoxide hydrolase inhibitors is disclosed. The benzohomoadamantane scaffold is a polycyclic, readily accessible, system that features a homoadamantane unit fused with an aromatic ring.
S. Codony, E. Valverde, C. Galdeano, A.L. Turcu, R. Leiva, S. Vázquez   +5 more
doaj   +1 more source

Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase

Journal of Lipid Research, 2012
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has a C-terminus epoxide hydrolase domain and an N-terminus phosphatase domain. The endogenous substrates of epoxide hydrolase are known to be epoxyeicosatrienoic acids, but the endogenous ...
Ami Oguro, Susumu Imaoka
doaj   +1 more source

The role of soluble epoxide hydrolase and its inhibitors in depression

Brain, Behavior, & Immunity - Health, 2021
Evidence suggests that around 30 ​% of patients with depression do not respond to antidepressant treatment, with most of them having sub-chronic levels of inflammation.
Alessandra Borsini
doaj   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Discovery of soluble epoxide hydrolase inhibitors from natural products [PDF]

, 2014
With the goal of developing soluble epoxide hydrolase (sEH) inhibitors with novel chemical structures, the sEH inhibitory activities of 30 natural compounds were evaluated using both a fluorescent substrate, 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl
G H Lee, Soo Jin Oh, J Y Lee, J Y Ma, Y H Kim, S K Kim, S Y Lee   +6 more
core   +1 more source

TPPU inhibits inflammation-induced excessive autophagy to restore the osteogenic differentiation potential of stem cells and improves alveolar ridge preservation

Scientific Reports, 2023
Inflammation-induced autophagy is a double-edged sword. Dysfunction of autophagy impairs the differentiation capacity of mesenchymal stem cells and enhances inflammation-induced bone loss.
Haixia Dang, Weixian Chen, Lan Chen, Xinru Huo, Fu Wang   +4 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Linking an insect enzyme to hypertension: angiotensin II–epoxide hydrolase interactions [PDF]

, 2010
Derived from arachidonic acid, epoxyeicosatrienoic acids function as antihypertensive and antihypertrophic mediators in the cardiovascular system. Epoxyeicosatrienoic acids are generated by soluble epoxide hydrolase, an enzyme hydrolyzing the epoxide ...
Shyy, John Y.-J., Zhu, Yi, Shyy, John Y-J., Ai, Ding   +3 more
core   +1 more source