Results 71 to 80 of about 507,315 (208)

Soluble Epoxide Hydrolase Inhibitors and Heart Failure [PDF]

Cardiovascular Therapeutics, 2011
Cardiovascular disease remains one of the leading causes of death in the Western societies. Heart failure (HF) is due primarily to progressive myocardial dysfunction accompanied by myocardial remodeling. Once HF develops, the condition is, in most cases, irreversible and is associated with a very high mortality rate.
Hong, Qiu, Ning, Li, Jun-Yan, Liu, Todd R, Harris, Bruce D, Hammock, Nipavan, Chiamvimonvat   +5 more
openaire   +2 more sources

Role of the soluble epoxide hydrolase and cytochrome P450-derived epoxyeicosatrienoic acids in hypoxic pulmonary vasoconstriction and hypoxia-induced pulmonary vascular remodelling [PDF]

, 2009
Hypoxic pulmonary vasoconstriction (HPV) redistributes pulmonary blood flow from areas of low oxygen partial pressure to areas of normal or relativity high oxygen availability, thus optimising the matching of perfusion to ventilation and preventing ...
Keserü, Benjamin
core  

Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: evidence for isozyme variants

, 1999
Endogenous, constitutive soluble epoxide hydrolase in mice 3T3 cells was localized via immunofluorescence microscopy exclusively in peroxisomes, whereas transiently expressed mouse soluble epoxide hydrolase (from clofibrate-treated liver) accumulated ...
Oesch, F, David F Grant, Arand, Michael; https://orcid.org/, Robert T Mullen, Franz Oesch, Richard N Trelease, Hammock, B D, Heike Duerk, Bruce D Hammock, Trelease, R N, Michael Arand, Duerk, H, Mullen, R T, Grant, D F   +13 more
core   +1 more source

Synthesis and structure–activity relationships for some novel diflapolin derivatives with benzimidazole subunit

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A series of derivatives of the potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor diflapolin was designed, synthesised, and characterised.
Lisa Vieider, Eva Zoeller, Erik Romp, Martin Schoenthaler, Victor Hernández-Olmos, Veronika Temml, Thomas Hasenoehrl, Daniela Schuster, Oliver Werz, Ulrike Garscha, Barbara Matuszczak   +10 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Proton Shuttles and Phosphatase Activity in Soluble Epoxide Hydrolase [PDF]

Journal of the American Chemical Society, 2006
Recently, a novel metal Mg2+-dependent phosphatase activity has been discovered in the N-terminal domain of the soluble epoxide hydrolase (sEH), opening a new branch of fatty acid metabolism and providing an additional site for drug targeting. Importantly, the sEH N-terminal fold belongs to the haloacid dehalogenase (HAD) superfamily, which comprises a
De Vivo, M., Ensing, B., Dal Peraro, M., Gomez, G. A., Christianson, D. W., Klein, M. L.   +5 more
openaire   +2 more sources

Photobiocatalytic Linear Deracemization of β‐Hydroxynitriles

ChemSusChem, Volume 19, Issue 19, 14 October 2026.
Photosensitizers were screened for the oxidation of β‐hydroxynitriles under blue light irradiation, finding tetra‐n‐butyl decatungstate as the most suitable catalyst for accessing ketonitriles. Subsequently, bioreductions were carried out, leading to the identification of stereocomplementary alcohol dehydrogenases for the development of a linear ...
Sara Filgueira, Fernando López‐Gallego, Vicente Gotor‐Fernández   +2 more
wiley   +1 more source

The Cloning and Characterization of a Soluble Epoxide Hydrolase in Chicken

Poultry Science, 2006
The mammalian soluble epoxide hydrolase (sEH) plays a role in the regulation of blood pressure and vascular homeostasis through its hydrolysis of the endothelial-derived messenger molecules, the epoxyeicosatrienoic acids. This study reports the cloning and expression of a sEH homolog from chicken liver.
T R, Harris, C, Morisseau, R L, Walzem, S J, Ma, B D, Hammock   +4 more
openaire   +2 more sources