Results 71 to 80 of about 7,307 (207)

The Cloning and Characterization of a Soluble Epoxide Hydrolase in Chicken

Poultry Science, 2006
The mammalian soluble epoxide hydrolase (sEH) plays a role in the regulation of blood pressure and vascular homeostasis through its hydrolysis of the endothelial-derived messenger molecules, the epoxyeicosatrienoic acids. This study reports the cloning and expression of a sEH homolog from chicken liver.
T R, Harris, C, Morisseau, R L, Walzem, S J, Ma, B D, Hammock   +4 more
openaire   +2 more sources

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Role of the soluble epoxide hydrolase and cytochrome P450-derived epoxyeicosatrienoic acids in hypoxic pulmonary vasoconstriction and hypoxia-induced pulmonary vascular remodelling [PDF]

, 2009
Hypoxic pulmonary vasoconstriction (HPV) redistributes pulmonary blood flow from areas of low oxygen partial pressure to areas of normal or relativity high oxygen availability, thus optimising the matching of perfusion to ventilation and preventing ...
Keserü, Benjamin
core  

Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs [PDF]

European Journal of Pharmaceutical Sciences, 2010
Epoxyeicosatrienoic acids that have anti-hypertensive and anti-inflammatory properties are mainly metabolized by soluble epoxide hydrolase (sEH, EC 3.3.2.3). Therefore, sEH has emerged as a therapeutic target for treating various cardiovascular diseases and inflammatory pain. N,N'-Disubstituted ureas are potent sEH inhibitors in vitro. However, in vivo
Hsing-Ju, Tsai, Sung Hee, Hwang, Christophe, Morisseau, Jun, Yang, Paul D, Jones, Takeo, Kasagami, In-Hae, Kim, Bruce D, Hammock   +7 more
openaire   +2 more sources

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase [PDF]

, 2007
Cyclooxygenase and lipoxygenase metabolism of arachidonic acid produces compounds important in cardiovascular control. Further, arachidonic acid can be metabolised by cytochrome p450 to produce epoxyeicosatrienoic acids (EETs).
Hammock, Bruce O., Hoey, Andrew, Brown, Lindsay, Morisseau, Christophe, Loch, David   +4 more
core  

Impact of the acute local inhibition of soluble epoxide hydrolase on diabetic skin microcirculatory dysfunction [PDF]

, 2019
International audienceThe impact of the local inhibition of soluble epoxide hydrolase, which metabolizes vasodilator and anti-inflammatory epoxyeicosanoids, on diabetic skin microvascular dysfunction was assessed. In diabetic db/db mice, basal skin blood
Richard, Vincent, Bellien, Jeremy, Roustit, Matthieu, Morisseau, Christophe, Hammock, Bruce, Skiba, Mohamed, Imbert, Laurent, Cornic, Marie, Bounoure, Frédéric, Thiébaut, Pierre-Alain, Picquenot, Jean-Michel, Savina, Yann, Kotzki, Sylvain, Duflot, Thomas, Cracowski, Jean-Luc, Serreau, Pierre-Alex   +15 more
core   +1 more source

Association between the soluble epoxide hydrolase gene and preeclampsia

Hypertension in Pregnancy, 2017
Objective: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women.
Ismail Sari, Hatice Pinarbasi, Ergun Pinarbasi, Caglar Yildiz   +3 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, Volume 16, Issue 7, Page 1328-1339, July 2026.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health [PDF]

Annual Review of Pharmacology and Toxicology, 2013
The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago. However, appreciation of their importance in cell biology and physiology has greatly accelerated over the past decade with the discovery of metabolically stable inhibitors of sEH, the ...
Christophe, Morisseau, Bruce D, Hammock
openaire   +2 more sources